Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
2,316
Total Reports
53
Deaths Reported
230.0%
Death Rate
4.0 yr
Avg Age at Report
Average weight at time of report: 26.3 kg (58.0 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 509
Vomiting 362
INEFFECTIVE, HEARTWORM LARVAE 264
Lethargy (see also Central nervous system depression in 'Neurological') 144
Emesis 140
Lack of efficacy (endoparasite) - hookworm 136
Lack of efficacy - NOS 131
Diarrhoea 119
Lack of efficacy (ectoparasite) - flea 75
Cardiac disorder NOS 72
Seizure NOS 63
INEFFECTIVE, HOOKS 62
Other abnormal test result NOS 47
Digestive tract disorder NOS 43
Lack of efficacy (ectoparasite) - tick NOS 43
Most Referenced Drugs
Milbemycin Oxime + Spinosad 511
Ivermectin + Pyrantel As Pamoate Salt 407
Moxidectin 240
Milbemycin Oxime + Praziquantel 186
Pyrantel Pamoate;Sarolaner 148
Afoxolaner 111
Fluralaner Chew Tablets 75
Spinosad 69
Melarsomine Dihydrochloride 64
Ivermectin 52
Lufenuron + Milbemycin Oxime 52
Oclacitinib Maleate 49
Milbemycin Oxime 47
Bedinvetmab 47
Sarolaner 45
Outcome Breakdown
Outcome Unknown
794 (35.4%)
Ongoing
671 (29.9%)
Recovered/Normal
570 (25.4%)
Recovered with Sequela
158 (7.0%)
Died
31 (1.4%)
Euthanized
22 (1.0%)
Gender Distribution
Female 1,231 (53.2%)
Male 1,053 (45.5%)
Unknown 22 (0.9%)
Mixed 10 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 48 | |
| 2011 | 51 | |
| 2012 | 76 | |
| 2013 | 124 | |
| 2014 | 144 | |
| 2015 | 148 | |
| 2016 | 164 | |
| 2017 | 173 | |
| 2018 | 195 | |
| 2019 | 208 | |
| 2020 | 183 | |
| 2021 | 193 | |
| 2022 | 159 | |
| 2023 | 157 | |
| 2024 | 179 | |
| 2025 | 114 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #75 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.