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2026 FDA CVM data 2,316 reports on file official source

Catahoula Leopard Dog — FDA Adverse Event Profile

Adverse-event records and label data for Catahoula Leopard Dog (Dog), sourced from the FDA Center for Veterinary Medicine. Refreshed as new reports are filed. Cite PlainBreed when reusing this analysis.

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Annual breed adverse-event registration timeline Bar chart showing yearly FDA Center for Veterinary Medicine adverse event report counts per breed registry cohort, with paw-print tick marks indicating count buckets. 208 156 104 52 0 2018 2019 2020 2021 2022 2023 2024 2025 Reports filed Death-coded reports
Annual report volume for Catahoula Leopard Dog drawn from FDA CVM filings.

Catahoula Leopard Dog (Dog) has 2,316 FDA adverse event reports on record, with 53 deaths reported (230.0% death rate) — ranking #75 by report volume. The most frequently reported reaction is Lack of efficacy (endoparasite) - heartworm (509 cases). The top associated drug is Milbemycin Oxime + Spinosad. Average age at report: 4.0 years.

Total Reports

2,316

FDA CVM filings

Deaths Reported

53

of 2,316 reports

Death Rate

230.0%

death-coded share

Avg Age at Report

4.0 yr

26.3 kg avg weight

Death-Coded Outcome Share

Catahoula Leopard Dog death-coded reports 100.0%
Database median

230.0% of 2,316 reports involved a death outcome. Read alongside breed popularity, veterinary access, and owner awareness — these shape how many events ever reach the FDA. The 12% comparison line is the rough cross-breed median in the FDA CVM database; values above suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Average weight at time of report: 26.3 kg (58.0 lbs)

Top Reported Reactions

Lack of efficacy (endoparasite) - heartworm 509
Vomiting 362
INEFFECTIVE, HEARTWORM LARVAE 264
Lethargy (see also Central nervous system depression in 'Neurological') 144
Emesis 140
Lack of efficacy (endoparasite) - hookworm 136
Lack of efficacy - NOS 131
Diarrhoea 119
Lack of efficacy (ectoparasite) - flea 75
Cardiac disorder NOS 72
Seizure NOS 63
INEFFECTIVE, HOOKS 62
Other abnormal test result NOS 47
Digestive tract disorder NOS 43
Lack of efficacy (ectoparasite) - tick NOS 43

Most Referenced Drugs

Milbemycin Oxime + Spinosad 511
Ivermectin + Pyrantel As Pamoate Salt 407
Moxidectin 240
Milbemycin Oxime + Praziquantel 186
Pyrantel Pamoate;Sarolaner 148
Afoxolaner 111
Fluralaner Chew Tablets 75
Spinosad 69
Melarsomine Dihydrochloride 64
Ivermectin 52
Lufenuron + Milbemycin Oxime 52
Oclacitinib Maleate 49
Milbemycin Oxime 47
Bedinvetmab 47
Sarolaner 45

Outcome Breakdown

Outcome Unknown
794 (35.4%)
Ongoing
671 (29.9%)
Recovered/Normal
570 (25.4%)
Recovered with Sequela
158 (7.0%)
Died
31 (1.4%)
Euthanized
22 (1.0%)

Gender Distribution

Female 1,231 (53.2%)
Male 1,053 (45.5%)
Unknown 22 (0.9%)
Mixed 10 (0.4%)

Reports by Year

Year Reports Trend
2010 48
2011 51
2012 76
2013 124
2014 144
2015 148
2016 164
2017 173
2018 195
2019 208
2020 183
2021 193
2022 159
2023 157
2024 179
2025 114
Size-class weight distribution across registered breeds Vertical bar chart showing the distribution of registered breeds across five size classes (Toy, Small, Medium, Large, Giant), each represented by a scaled dog-silhouette and a count value. 118 89 59 30 0 Breeds in class 38 Toy 0–6 kg Chihuahua 64 Small 6–14 kg Beagle 92 Medium 14–27 kg Border Collie 118 Large 27–45 kg Labrador Retriever 41 Giant 45–90 kg Great Dane Size-Class Distribution
Where Catahoula Leopard Dog sits in the registered size-class taxonomy. Average reported weight: 26.3 kg.
Breed-group distribution donut chart Donut chart with kennel-club-ribbon center showing breed counts across the eight standard breed groups (Sporting, Hound, Working, Terrier, Toy, Non-Sporting, Herding, Miscellaneous). CH Sporting 32 · 14.2% Hound 36 · 15.9% Working 33 · 14.6% Terrier 31 · 13.7% Toy 23 · 10.2% Non-Sporting 21 · 9.3% Herding 32 · 14.2% Misc. 18 · 8.0% Breed-Group Classification 226 breeds across 8 taxonomic groups
Eight standard breed-group classifications used by major registries (AKC's seven groups plus Miscellaneous). Provides taxonomic context for breed lookups.

Catahoula Leopard Dog Pet Health Insights

Across the FDA Center for Veterinary Medicine adverse event database, Catahoula Leopard Dog accounts for 2,316 submitted reports and currently ranks #75 by report volume within the dog population. Of those reports, 53 involved a death outcome — a 230.0% case-fatality figure calculated directly from the underlying FDA records rather than from external mortality studies. The mean age at time of reporting is 4.0 years, with an average recorded body weight of 26.3 kg (58.0 lbs). These figures reflect the voluntary reporting pool only and should be read alongside breed popularity, veterinary access, and owner awareness — all of which shape how many events ever reach the FDA.

The most frequently reported clinical signs for Catahoula Leopard Dog are Lack of efficacy (endoparasite) - heartworm (509 reports), Vomiting (362 reports), INEFFECTIVE, HEARTWORM LARVAE (264 reports), together capturing a substantial share of the top-reaction traffic seen in this breed's record. On the product side, Milbemycin Oxime + Spinosad appears in 511 reports and is the single most-referenced drug, followed by Ivermectin + Pyrantel As Pamoate Salt (407) and Moxidectin (240). Counts like these surface which therapeutic classes dominate the reporting stream — useful context when comparing reactions across breeds of the same dog species.

Outcome coding on the 2,246 reports with a recorded status is dominated by Outcome Unknown (35.4% of coded outcomes). Annual submission volume ranges from 2,010 to 2,025 reports across the 16 years on file, indicating the reporting trend is shaped as much by awareness cycles as by underlying clinical events. Because FDA adverse event reports describe correlation rather than causation, these numbers are most useful as a signal of where to ask further questions with a veterinarian — not as a standalone risk score for any individual dog.

Understanding Catahoula Leopard Dog Adverse Event Data

Catahoula Leopard Dog has a moderate volume of adverse event reports (2,316). Report counts are influenced by breed popularity, owner awareness, and veterinary reporting practices.

The 230.0% death rate is above average, though this statistic should be interpreted cautiously. Death reports may be overrepresented because serious outcomes are more likely to be reported than mild reactions.

The most frequently referenced drug in adverse reports is Milbemycin Oxime + Spinosad, appearing in 511 reports. This may indicate widespread use of the medication rather than a specific safety concern for Catahoula Leopard Dog.

Other Dog Breeds

Frequently Asked Questions

How many FDA adverse event reports involve Catahoula Leopard Dog?
There are 2,316 adverse event reports involving Catahoula Leopard Dog in the FDA database, with 53 reports involving death (230.0% death rate). Catahoula Leopard Dog ranks #75 by report volume.
What are the most common adverse reactions reported for Catahoula Leopard Dog?
The most commonly reported adverse reactions for Catahoula Leopard Dog are Lack of efficacy (endoparasite) - heartworm (509 reports), Vomiting (362 reports), INEFFECTIVE, HEARTWORM LARVAE (264 reports), Lethargy (see also Central nervous system depression in 'Neurological') (144 reports), Emesis (140 reports).
What drugs are most frequently associated with Catahoula Leopard Dog adverse events?
The drugs most frequently referenced in Catahoula Leopard Dog adverse event reports are Milbemycin Oxime + Spinosad (511 reports), Ivermectin + Pyrantel As Pamoate Salt (407 reports), Moxidectin (240 reports), Milbemycin Oxime + Praziquantel (186 reports), Pyrantel Pamoate;Sarolaner (148 reports).
What is the average age of Catahoula Leopard Dog in adverse event reports?
The average age of Catahoula Leopard Dog at the time of adverse event reports is 4.0 years, with an average weight of 26.3 kg (58.0 lbs).
Does a high number of adverse event reports mean Catahoula Leopard Dog is unhealthy?
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Catahoula Leopard Dog safety data come from?
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.

Guides & Resources

Related Data Sources

Data Sources & Methodology

Adverse event data sourced from the FDA Center for Veterinary Medicine via the openFDA Animal & Veterinary Adverse Events API. Reports are voluntarily submitted by pet owners, veterinarians, and product manufacturers.

Catahoula Leopard Dog ranks #75 by total report volume. Death rate (230.0%) reflects the proportion of reports involving death and should not be interpreted as a breed-specific mortality rate. Reporting biases, breed popularity, and veterinary access all influence report counts.

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial