Total Reports
2,316
FDA CVM filings
Dog /
FDA CVM · 2025 release 2,316 reports on file
Catahoula Leopard Dog - FDA Adverse Event Profile
Adverse-event records for Catahoula Leopard Dog (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Catahoula Leopard Dog's FDA record: #75 most-reported dog breed, 2,316 total reports, 2.3% death-coded (53 reports).
- #75
- most-reported dog breed
- 2.3%
- death-coded report share
- 509
- Lack of efficacy (endoparasite) - heartworm - top reaction
- 4.0 yr
- average age at report
Report counts track breed popularity and reporting activity, not real-world risk, read this alongside how common the breed is.
Deaths Reported
53
of 2,316 reports
Death Rate
2.3%
death-coded share
Avg Age at Report
4.0 yr
26.3 kg avg weight
Death-Coded Outcome Share
Catahoula Leopard Dog death-coded reports 2.3%
Cross-breed median
2.3% of 2,316 catahoula leopard dog reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 26.3 kg (58.0 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 509
Vomiting 362
INEFFECTIVE, HEARTWORM LARVAE 264
Lethargy (see also Central nervous system depression in 'Neurological') 144
Emesis 140
Lack of efficacy (endoparasite) - hookworm 136
Lack of efficacy - NOS 131
Diarrhoea 119
Lack of efficacy (ectoparasite) - flea 75
Cardiac disorder NOS 72
Seizure NOS 63
INEFFECTIVE, HOOKS 62
Other abnormal test result NOS 47
Digestive tract disorder NOS 43
Lack of efficacy (ectoparasite) - tick NOS 43
Most Referenced Drugs
Milbemycin Oxime + Spinosad 511
Ivermectin + Pyrantel As Pamoate Salt 407
Moxidectin 240
Milbemycin Oxime + Praziquantel 186
Pyrantel Pamoate;Sarolaner 148
Afoxolaner 111
Fluralaner Chew Tablets 75
Spinosad 69
Melarsomine Dihydrochloride 64
Ivermectin 52
Lufenuron + Milbemycin Oxime 52
Oclacitinib Maleate 49
Milbemycin Oxime 47
Bedinvetmab 47
Sarolaner 45
Outcome Breakdown
Outcome Unknown
794 (35.4%)
Ongoing
671 (29.9%)
Recovered/Normal
570 (25.4%)
Recovered with Sequela
158 (7.0%)
Died
31 (1.4%)
Euthanized
22 (1.0%)
Gender Distribution
Female 1,231 (53.2%)
Male 1,053 (45.5%)
Unknown 22 (0.9%)
Mixed 10 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 48 | |
| 2011 | 51 | |
| 2012 | 76 | |
| 2013 | 124 | |
| 2014 | 144 | |
| 2015 | 148 | |
| 2016 | 164 | |
| 2017 | 173 | |
| 2018 | 195 | |
| 2019 | 208 | |
| 2020 | 183 | |
| 2021 | 193 | |
| 2022 | 159 | |
| 2023 | 157 | |
| 2024 | 179 | |
| 2025 | 114 | |
Catahoula Leopard Dog Pet Health Insights
Catahoula Leopard Dog accounts for 2,316 FDA adverse event reports, ranking #75 by volume among dog breeds, with 53 reports (2.3%) coded as a death outcome. Mean age at report: 4.0 years, average weight 26.3 kg (58.0 lbs).
Top reported signs: Lack of efficacy (endoparasite) - heartworm (509), Vomiting (362), INEFFECTIVE, HEARTWORM LARVAE (264). Most-referenced drug: Milbemycin Oxime + Spinosad (511 reports), followed by Ivermectin + Pyrantel As Pamoate Salt (407) and Moxidectin (240).
Outcome coding on 2,246 status-recorded reports is dominated by Outcome Unknown (35.4%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Dog Breeds With a Similar Report Volume
Bulldog - American
2,409 reports · 4.9% death rate
Spaniel - Springer English
2,187 reports · 3.9% death rate
Weimaraner
2,480 reports · 4.6% death rate
Pekingese
2,525 reports · 4.0% death rate
Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne))
2,087 reports · 4.4% death rate
Chow Chow
2,029 reports · 6.4% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Catahoula Leopard Dog? ▼
There are 2,316 adverse event reports involving Catahoula Leopard Dog in the FDA database, with 53 reports involving death (2.3% death rate). Catahoula Leopard Dog ranks #75 by report volume.
What are the most common adverse reactions reported for Catahoula Leopard Dog? ▼
The most commonly reported adverse reactions for Catahoula Leopard Dog are Lack of efficacy (endoparasite) - heartworm (509 reports), Vomiting (362 reports), INEFFECTIVE, HEARTWORM LARVAE (264 reports), Lethargy (see also Central nervous system depression in 'Neurological') (144 reports), Emesis (140 reports).
What drugs are most frequently associated with Catahoula Leopard Dog adverse events? ▼
The drugs most frequently referenced in Catahoula Leopard Dog adverse event reports are Milbemycin Oxime + Spinosad (511 reports), Ivermectin + Pyrantel As Pamoate Salt (407 reports), Moxidectin (240 reports), Milbemycin Oxime + Praziquantel (186 reports), Pyrantel Pamoate;Sarolaner (148 reports).
What is the average age of Catahoula Leopard Dog in adverse event reports? ▼
The average age of Catahoula Leopard Dog at the time of adverse event reports is 4.0 years, with an average weight of 26.3 kg (58.0 lbs).
Does a high number of adverse event reports mean Catahoula Leopard Dog is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Catahoula Leopard Dog safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.