Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
47,381
Total Reports
4,140
Deaths Reported
870.0%
Death Rate
5.8 yr
Avg Age at Report
Average weight at time of report: 18.1 kg (39.9 lbs)
Top Reported Reactions
Vomiting 8,278
Lack of efficacy (ectoparasite) - flea 5,693
Lack of efficacy - NOS 3,281
Death 3,013
Diarrhoea 2,243
Lethargy (see also Central nervous system depression in 'Neurological') 1,843
Emesis 1,677
Seizure NOS 1,560
Lack of efficacy (ectoparasite) - tick NOS 1,388
Lack of efficacy (endoparasite) - heartworm 1,206
Lack of efficacy (flea) 1,023
Lack of efficacy (endoparasite) - hookworm 979
Death by euthanasia 866
INEFFECTIVE, HEARTWORM LARVAE 806
Behavioural disorder NOS 696
Most Referenced Drugs
Milbemycin Oxime + Spinosad 5,114
Afoxolaner 4,871
Ivermectin + Pyrantel As Pamoate Salt 3,497
Pyrantel Pamoate;Sarolaner 3,189
Spinosad 2,958
Oclacitinib Maleate 1,852
Milbemycin Oxime + Praziquantel 1,407
Fluralaner 13.64% 12-Week Chew 1,372
Bedinvetmab 1,350
Sarolaner 1,308
Nitenpyram 1,084
Moxidectin 1,029
Fluralaner Chew Tablets 983
Selamectin 819
Carprofen 796
Outcome Breakdown
Outcome Unknown
26,246 (59.1%)
Recovered/Normal
8,506 (19.1%)
Ongoing
5,109 (11.5%)
Died
3,246 (7.3%)
Euthanized
897 (2.0%)
Recovered with Sequela
418 (0.9%)
Gender Distribution
Unknown 31,015 (65.5%)
Female 8,161 (17.2%)
Male 7,896 (16.7%)
Mixed 309 (0.7%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 1,521 | |
| 2011 | 1,737 | |
| 2012 | 2,204 | |
| 2013 | 2,318 | |
| 2014 | 2,225 | |
| 2015 | 2,802 | |
| 2016 | 3,321 | |
| 2017 | 3,732 | |
| 2018 | 3,475 | |
| 2019 | 3,497 | |
| 2020 | 3,458 | |
| 2021 | 3,543 | |
| 2022 | 3,422 | |
| 2023 | 3,560 | |
| 2024 | 4,043 | |
| 2025 | 2,523 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #4 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.