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Breed profile · FDA CVM July 2026 extract

Dog (unknown) adverse-event record

Adverse-event filings for Dog (unknown) (Dog) in the FDA Center for Veterinary Medicine openFDA extract. Browse dog breeds, reactions, and outcomes below.

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#4 of 510
by report volume (all breeds)
48,820
FDA CVM reports on file
8.8%
death-coded share of reports
#59 of 275
by death-coded share (≥50 reports)

How the 48,820 reports break down

By recorded gender -- every report on file for Dog (unknown), no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 4,079 3,059.25 2,039.5 1,019.75 0 2019 2020 2021 2022 2023 2024 2025 2026 Reports filed Death-coded reports
Annual report volume for Dog (unknown) drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Dog (unknown) ranks #4 of 510 by total reports (48,820) and #59 of 275 by death-coded share (8.8%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#4
This breed, reports of 510
#59
This breed, death share of 275

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Dog (unknown) has 48,820 reports now versus 48,247 in that prior snapshot: 573 more (1.2%).

Report change
+573
Death-coded reports
+70
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Dog (unknown) changes

Total Reports

48,820

Highest-reported breed

Deaths Reported

4,298

of 48,820 reports

Death-coded share of reports

8.8%

High death-coded share

Avg Age at Report

5.8 yr

18.1 kg avg weight

Breed Safety Scorecard

F (34/100)

A weighted composite across 4 of 4 dimensions, each benchmarked against every tracked breed with at least 200 reports (n=185). Dimensions with insufficient data drop out and their weight redistributes to the rest, so a missing input never silently deflates the score.

Death rate F
8.8%

Share of reports coded as a fatality

Euthanasia rate C+
1.9%

Share of reports resulting in euthanasia

Full recovery rate F
17.9%

Share of reports coded "Recovered/Normal"

5-year trend C+
-3%

Change in annual report volume over the last 5 complete years

Death-Coded Outcome Share

Dog (unknown) death-coded reports 8.8%
Cross-breed median

8.8% of 48,820 dog (unknown) reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Where Dog (unknown)'s death-coded share sits among indexed breeds

Death-coded share of FDA CVM reports, breeds with ≥50 reports (July 2026 extract)

9% 79th percentile Higher share than 79% of 275 indexed breeds

5%–10%: 1 indexed breeds (0%). This entry sits in this band. 20%–25%: 2 indexed breeds (1%). Above this entry. 25%–30%: 3 indexed breeds (1%). Above this entry. 30%–35%: 4 indexed breeds (1%). Above this entry. 35%–40%: 5 indexed breeds (2%). Above this entry. 40%–45%: 6 indexed breeds (2%). Above this entry. 45%–50%: 3 indexed breeds (1%). Above this entry. 50%–55%: 7 indexed breeds (3%). Above this entry. 55%–60%: 7 indexed breeds (3%). Above this entry. 60%–65%: 21 indexed breeds (8%). Above this entry. 65%–70%: 11 indexed breeds (4%). Above this entry. 70%–75%: 15 indexed breeds (5%). Above this entry. 75%–80%: 13 indexed breeds (5%). Above this entry. 80%–85%: 11 indexed breeds (4%). Above this entry. 85%–90%: 12 indexed breeds (4%). Above this entry. 90%–95%: 12 indexed breeds (4%). Above this entry. 95%–100%: 142 indexed breeds (52%). Above this entry. Dog (unknown) 5% 100% every breed with ≥50 FDA reports, bucketed by value

Each bar is a band; taller bars hold more indexed breeds. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.

Source FDA Center for Veterinary Medicine, openFDA adverse event extract (PlainBreed) · July 2026 extract

This histogram uses the same ≥50-report cohort as the highest death-coded share ranking. A higher share means more of this breed's reported events were death-coded, not a mortality rate for living animals.

Dog (unknown) among report-volume vs. death-rate peers

Every breed shown has at least 50 filed reports. Volume reflects how often a breed is reported, not how common it is; death rate is the share of a breed's own reports coded as a death outcome.

Source: FDA openFDA Animal & Veterinary Adverse Events database 2×2 strategic matrix plotting 30 entities by Total Reports (X) and Death Rate (%) (Y), with a crosshair dividing the plot into four quadrants. High volume, high death rateLow volume, high death rateHigh volume, low death rateLow volume, low death rate 020,00040,00060,00080,000100,000 0%5%10%15% Total Reports Death Rate (%) Dog (unknown) vs. all breeds, report volume and death-coded share Retriever - Labrador-93675, 3.7%Crossbred Canine/dog-70591, 3.2%Domestic Shorthair-65226, 7.2%Dog (unknown)-48820, 8.8%Retriever - Golden-35980, 3.7%Shepherd Dog - German-32220, 4.4%Chihuahua-31521, 4.2%Terrier - Yorkshire-24924, 3.7%Shih Tzu-24405, 3.6%Boxer (German Boxer)-19405, 4.4%Beagle-17970, 3.6%Pit Bull-17865, 3.1%Shepherd Dog - Australian-16274, 3.7%Terrier (unspecified)-14058, 3.1%Maltese-13940, 3.2%Dachshund (unspecified)-13512, 4.6%Cat (unknown)-13248, 9.3%Terrier - Jack Russell-10423, 3.7%Collie - Border-10130, 4.3%Siberian Husky-9811, 4.5%Domestic Longhair-9615, 7%Pug-9224, 5.2%Spitz - German Pomeranian-9086, 4.9%Terrier - Bull - American Pit-8769, 4.7%Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog)-7871, 3.6%Terrier - Boston-7737, 4.5%Spaniel - Cocker American-7640, 4%Domestic (unspecified)-7576, 13.4%Poodle (unspecified)-7534, 3.4%Schnauzer - Miniature-7513, 4.4%
Source: FDA openFDA Animal & Veterinary Adverse Events database
Average weight at time of report: 18.1 kg (39.9 lbs)

Top Reported Reactions

Vomiting 8,471
Lack of efficacy (ectoparasite) - flea 5,915
Lack of efficacy - NOS 3,390
Death 3,124
Diarrhoea 2,316
Lethargy (see also Central nervous system depression in 'Neurological') 1,843
Emesis 1,686
Seizure NOS 1,615
Lack of efficacy (ectoparasite) - tick NOS 1,443
Lack of efficacy (endoparasite) - heartworm 1,265
Lack of efficacy (endoparasite) - hookworm 1,029
Lack of efficacy (flea) 1,023
Death by euthanasia 896
INEFFECTIVE, HEARTWORM LARVAE 806
Behavioural disorder NOS 716

Most Referenced Drugs

Milbemycin Oxime + Spinosad 5,142
Afoxolaner 4,946
Ivermectin + Pyrantel As Pamoate Salt 3,575
Pyrantel Pamoate;Sarolaner 3,390
Spinosad 2,962
Oclacitinib Maleate 1,921
Fluralaner 13.64% 12-Week Chew 1,522
Bedinvetmab 1,479
Milbemycin Oxime + Praziquantel 1,439
Sarolaner 1,326
Nitenpyram 1,117
Moxidectin 1,062
Fluralaner Chew Tablets 983
Selamectin 837
Carprofen 808

Outcome Breakdown

Outcome Unknown
27,042 (59.0%)
Recovered/Normal
8,718 (19.0%)
Ongoing
5,381 (11.7%)
Died
3,372 (7.4%)
Euthanized
929 (2.0%)
Recovered with Sequela
422 (0.9%)

Gender Distribution

Unknown 31,895 (65.3%)
Female 8,437 (17.3%)
Male 8,172 (16.7%)
Mixed 316 (0.6%)

Reports by Year

Year Reports Trend
2010 1,522
2011 1,738
2012 2,206
2013 2,318
2014 2,224
2015 2,802
2016 3,324
2017 3,733
2018 3,477
2019 3,497
2020 3,462
2021 3,543
2022 3,433
2023 3,571
2024 4,079
2025 3,445
2026 446

Dog (unknown): high death-coded share in the FDA CVM extract

Signature read: 48,820 reports place Dog (unknown) in the upper third of breed filing volume (#4 of 510). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Dog (unknown) sits at #4 of 510 by report volume among all breeds and #3 of 298 among dog breeds, with 48,820 reports and 4,298 (8.8%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #59 of 275. Mean age at report: 5.8 years, average weight 18.1 kg (39.9 lbs).

Top reported signs: Vomiting (8,471), Lack of efficacy (ectoparasite) - flea (5,915), Lack of efficacy - NOS (3,390). Most-referenced drug: Milbemycin Oxime + Spinosad (5,142 reports), followed by Afoxolaner (4,946) and Ivermectin + Pyrantel As Pamoate Salt (3,575).

Outcome coding on 45,864 status-recorded reports is dominated by Outcome Unknown (59.0%). Annual submissions ranged 446-2,026 across 17 years on file.

Dog (unknown) Reporting Concentration Profile

Dog (unknown) is a high-volume FDA CVM cohort (48,820 reports) - enough filings to measure how concentrated the reaction and drug mix is, not just the headline totals. Across 20 named reaction terms in the stored top list, the leading three (Vomiting, Lack of efficacy (ectoparasite) - flea, Lack of efficacy - NOS) account for 46.1% of listed reaction mentions. The Herfindahl index on that list is 0.102 (1.0 = a single reaction owns every mention; lower = a broader clinical mix).

On the drug side, 20 referenced products appear in the top list; the leading three (Milbemycin Oxime + Spinosad, Afoxolaner, Ivermectin + Pyrantel As Pamoate Salt) cover 38.3% of those mentions. That multi-product footprint is the profile thin-report breeds cannot show - their pages stop at a short bar list because the sample cannot support a concentration read.

Outcome coding on 45,864 status-recorded filings splits roughly 9.4% severe (died or euthanized - 4,301 reports) versus 19.9% recovered or recovered-with-sequela (9,140). Read that split next to the 8.8% death-coded share above - both track reporting severity bias in a popular breed, not a proven mortality rate.

Peak filing year was 2024 (4,079 reports); the lightest year on file was 2026 (446). From 2024 to 2025, annual volume fell 15.5% (4,079 → 3,445). Year-to-year swings at this volume usually track product launches, owner awareness, and reporting campaigns more than sudden breed-health shocks.

Dog Breeds With a Similar Report Volume

Showing 6 of 297 dog breeds in our dataset, ranked by closest report volume.

Retriever - Golden
35,980 reports · 3.7% death-coded
Shepherd Dog - German
32,220 reports · 4.4% death-coded
Chihuahua
31,521 reports · 4.2% death-coded
Crossbred Canine/dog
70,591 reports · 3.2% death-coded
Terrier - Yorkshire
24,924 reports · 3.7% death-coded
Shih Tzu
24,405 reports · 3.6% death-coded

Nationwide breeds with similar profiles

High-volume peer sets for Dog (unknown) drawn from openFDA outside the Dog family so the neighborhoods are not species containment (the similar-volume list above stays within species).

Similar death-coded share

Nearest other-species breeds with ≥50 reports (8.8% death-coded here).

Ragdoll 8.7% · Cat Scottish Fold Shorthair 8.3% · Cat Cat (unknown) 9.3% · Cat Thoroughbred 8.2% · Horse

Similar average weight

Nearest other-species breeds by reported average weight (18.1 kg here).

Pygmy 20.3 kg · Goat Crossbred Caprine/goat 21.7 kg · Goat Wild cat 14.5 kg · Cat Monkey (unspecified) 11.6 kg · Monkey

What to do with this dog

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve Dog (unknown)? ▼
There are 48,820 adverse event reports involving Dog (unknown) in the FDA database, of which 4,298 were death-coded (8.8% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Dog (unknown) ranks #4 of 510 by report volume among all breeds PlainBreed indexes (#3 of 298 among dog breeds).
Where does Dog (unknown) sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Dog (unknown) is #4 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Dog, it is #3 of 298. Among breeds with at least 50 reports, its death-coded share ranks #59 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Dog (unknown)? ▼
The most commonly reported adverse reactions for Dog (unknown) are Vomiting (8,471 reports), Lack of efficacy (ectoparasite) - flea (5,915 reports), Lack of efficacy - NOS (3,390 reports), Death (3,124 reports), Diarrhoea (2,316 reports).
What drugs are most frequently associated with Dog (unknown) adverse events? ▼
The drugs most frequently referenced in Dog (unknown) adverse event reports are Milbemycin Oxime + Spinosad (5,142 reports), Afoxolaner (4,946 reports), Ivermectin + Pyrantel As Pamoate Salt (3,575 reports), Pyrantel Pamoate;Sarolaner (3,390 reports), Spinosad (2,962 reports).
What is the average age of Dog (unknown) in adverse event reports? ▼
The average age of Dog (unknown) at the time of adverse event reports is 5.8 years, with an average weight of 18.1 kg (39.9 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Dog (unknown) (Dog), extract as of July 2026 extract. 48,820 reports · 4,298 death-coded (8.8% of reports, not a mortality rate) · #4 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →