Total Reports
47,381
FDA CVM filings
Dog /
FDA CVM · 2025 release 47,381 reports on file
Dog (unknown) - FDA Adverse Event Profile
Adverse-event records for Dog (unknown) (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Among dog breeds, Dog (unknown) is #4 by FDA report volume; 8.7% of its 47,381 reports (4,140) were death-coded.
- #4
- most-reported dog breed
- 8.7%
- death-coded report share
- 8,278
- Vomiting - top reaction
- 5.8 yr
- average age at report
Higher volume usually means a more popular breed, not a riskier one, compare against how common the breed is.
Deaths Reported
4,140
of 47,381 reports
Death Rate
8.7%
death-coded share
Avg Age at Report
5.8 yr
18.1 kg avg weight
Death-Coded Outcome Share
Dog (unknown) death-coded reports 8.7%
Cross-breed median
8.7% of 47,381 dog (unknown) reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 18.1 kg (39.9 lbs)
Top Reported Reactions
Vomiting 8,278
Lack of efficacy (ectoparasite) - flea 5,693
Lack of efficacy - NOS 3,281
Death 3,013
Diarrhoea 2,243
Lethargy (see also Central nervous system depression in 'Neurological') 1,843
Emesis 1,677
Seizure NOS 1,560
Lack of efficacy (ectoparasite) - tick NOS 1,388
Lack of efficacy (endoparasite) - heartworm 1,206
Lack of efficacy (flea) 1,023
Lack of efficacy (endoparasite) - hookworm 979
Death by euthanasia 866
INEFFECTIVE, HEARTWORM LARVAE 806
Behavioural disorder NOS 696
Most Referenced Drugs
Milbemycin Oxime + Spinosad 5,114
Afoxolaner 4,871
Ivermectin + Pyrantel As Pamoate Salt 3,497
Pyrantel Pamoate;Sarolaner 3,189
Spinosad 2,958
Oclacitinib Maleate 1,852
Milbemycin Oxime + Praziquantel 1,407
Fluralaner 13.64% 12-Week Chew 1,372
Bedinvetmab 1,350
Sarolaner 1,308
Nitenpyram 1,084
Moxidectin 1,029
Fluralaner Chew Tablets 983
Selamectin 819
Carprofen 796
Outcome Breakdown
Outcome Unknown
26,246 (59.1%)
Recovered/Normal
8,506 (19.1%)
Ongoing
5,109 (11.5%)
Died
3,246 (7.3%)
Euthanized
897 (2.0%)
Recovered with Sequela
418 (0.9%)
Gender Distribution
Unknown 31,015 (65.5%)
Female 8,161 (17.2%)
Male 7,896 (16.7%)
Mixed 309 (0.7%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 1,521 | |
| 2011 | 1,737 | |
| 2012 | 2,204 | |
| 2013 | 2,318 | |
| 2014 | 2,225 | |
| 2015 | 2,802 | |
| 2016 | 3,321 | |
| 2017 | 3,732 | |
| 2018 | 3,475 | |
| 2019 | 3,497 | |
| 2020 | 3,458 | |
| 2021 | 3,543 | |
| 2022 | 3,422 | |
| 2023 | 3,560 | |
| 2024 | 4,043 | |
| 2025 | 2,523 | |
Dog (unknown) Pet Health Insights
Dog (unknown) accounts for 47,381 FDA adverse event reports, ranking #4 by volume among dog breeds, with 4,140 reports (8.7%) coded as a death outcome. Mean age at report: 5.8 years, average weight 18.1 kg (39.9 lbs).
Top reported signs: Vomiting (8,278), Lack of efficacy (ectoparasite) - flea (5,693), Lack of efficacy - NOS (3,281). Most-referenced drug: Milbemycin Oxime + Spinosad (5,114 reports), followed by Afoxolaner (4,871) and Ivermectin + Pyrantel As Pamoate Salt (3,497).
Outcome coding on 44,422 status-recorded reports is dominated by Outcome Unknown (59.1%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Dog Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve Dog (unknown)? ▼
There are 47,381 adverse event reports involving Dog (unknown) in the FDA database, with 4,140 reports involving death (8.7% death rate). Dog (unknown) ranks #4 by report volume.
What are the most common adverse reactions reported for Dog (unknown)? ▼
The most commonly reported adverse reactions for Dog (unknown) are Vomiting (8,278 reports), Lack of efficacy (ectoparasite) - flea (5,693 reports), Lack of efficacy - NOS (3,281 reports), Death (3,013 reports), Diarrhoea (2,243 reports).
What drugs are most frequently associated with Dog (unknown) adverse events? ▼
The drugs most frequently referenced in Dog (unknown) adverse event reports are Milbemycin Oxime + Spinosad (5,114 reports), Afoxolaner (4,871 reports), Ivermectin + Pyrantel As Pamoate Salt (3,497 reports), Pyrantel Pamoate;Sarolaner (3,189 reports), Spinosad (2,958 reports).
What is the average age of Dog (unknown) in adverse event reports? ▼
The average age of Dog (unknown) at the time of adverse event reports is 5.8 years, with an average weight of 18.1 kg (39.9 lbs).
Does a high number of adverse event reports mean Dog (unknown) is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Dog (unknown) safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.