Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
13,165
Total Reports
599
Deaths Reported
450.0%
Death Rate
6.1 yr
Avg Age at Report
Average weight at time of report: 7.5 kg (16.5 lbs)
Top Reported Reactions
Vomiting 2,913
Lethargy (see also Central nervous system depression in 'Neurological') 1,276
Emesis 1,249
Lack of efficacy (ectoparasite) - flea 1,011
Diarrhoea 926
Lack of efficacy - NOS 725
INEFFECTIVE, HEARTWORM LARVAE 623
Lack of efficacy (endoparasite) - hookworm 585
Lack of efficacy (endoparasite) - heartworm 562
Seizure NOS 483
Anorexia 451
Digestive tract disorder NOS 363
Death 326
Other abnormal test result NOS 324
Behavioural disorder NOS 313
Most Referenced Drugs
Milbemycin Oxime + Spinosad 2,803
Spinosad 1,302
Ivermectin + Pyrantel As Pamoate Salt 1,203
Moxidectin 806
Afoxolaner 787
Pyrantel Pamoate;Sarolaner 505
Fluralaner Chew Tablets 459
Milbemycin Oxime + Praziquantel 397
Oclacitinib Maleate 331
Fluralaner 13.64% 12-Week Chew 306
Carprofen 303
Sarolaner 224
Nitenpyram 222
Imidacloprid + Moxidectin 213
Ivermectin, Pyrantel 211
Outcome Breakdown
Recovered/Normal
4,291 (36.6%)
Outcome Unknown
3,646 (31.1%)
Ongoing
2,662 (22.7%)
Recovered with Sequela
531 (4.5%)
Died
375 (3.2%)
Euthanized
224 (1.9%)
Gender Distribution
Male 6,472 (49.2%)
Female 6,366 (48.4%)
Unknown 277 (2.1%)
Mixed 50 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 763 | |
| 2011 | 1,011 | |
| 2012 | 1,159 | |
| 2013 | 1,051 | |
| 2014 | 1,057 | |
| 2015 | 988 | |
| 2016 | 933 | |
| 2017 | 950 | |
| 2018 | 837 | |
| 2019 | 768 | |
| 2020 | 679 | |
| 2021 | 617 | |
| 2022 | 553 | |
| 2023 | 653 | |
| 2024 | 662 | |
| 2025 | 484 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #16 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.