Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
439
Total Reports
12
Deaths Reported
270.0%
Death Rate
6.7 yr
Avg Age at Report
Average weight at time of report: 11.6 kg (25.6 lbs)
Top Reported Reactions
Vomiting 99
Lethargy (see also Central nervous system depression in 'Neurological') 56
Diarrhoea 40
Emesis 39
Anorexia 25
Lack of efficacy (ectoparasite) - flea 25
Lack of efficacy (endoparasite) - hookworm 24
Lack of efficacy - NOS 22
Other abnormal test result NOS 21
Behavioural disorder NOS 16
Digestive tract disorder NOS 15
Seizure NOS 15
Decreased appetite 14
Lack of efficacy (ectoparasite) - tick NOS 14
Elevated alanine aminotransferase (ALT) 13
Most Referenced Drugs
Milbemycin Oxime + Spinosad 70
Ivermectin + Pyrantel As Pamoate Salt 42
Afoxolaner 38
Oclacitinib Maleate 29
Spinosad 28
Fluralaner Chew Tablets 28
Pyrantel Pamoate;Sarolaner 17
Trilostane 13
Carprofen 12
Fluralaner 13.64% 12-Week Chew 11
Milbemycin Oxime + Praziquantel 10
Selamectin 9
Pimobendan 8
Cyclosporine A 8
Moxidectin 8
Outcome Breakdown
Recovered/Normal
164 (40.2%)
Outcome Unknown
110 (27.0%)
Ongoing
106 (26.0%)
Recovered with Sequela
16 (3.9%)
Euthanized
12 (2.9%)
Gender Distribution
Male 241 (54.9%)
Female 193 (44.0%)
Unknown 4 (0.9%)
Mixed 1 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 18 | |
| 2011 | 24 | |
| 2012 | 36 | |
| 2013 | 29 | |
| 2014 | 42 | |
| 2015 | 47 | |
| 2016 | 45 | |
| 2017 | 32 | |
| 2018 | 27 | |
| 2019 | 19 | |
| 2020 | 26 | |
| 2021 | 22 | |
| 2022 | 19 | |
| 2023 | 17 | |
| 2024 | 25 | |
| 2025 | 11 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #148 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.