Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
3,439
Total Reports
65
Deaths Reported
190.0%
Death Rate
4.4 yr
Avg Age at Report
Average weight at time of report: 29.0 kg (63.9 lbs)
Top Reported Reactions
Emesis 1,233
Vomiting 562
Lethargy (see also Central nervous system depression in 'Neurological') 325
Lack of efficacy (endoparasite) - heartworm 216
Diarrhoea 172
Lack of efficacy - NOS 156
Lack of efficacy (ectoparasite) - flea 138
Seizure NOS 103
Lack of efficacy (endoparasite) - hookworm 83
INEFFECTIVE, HEARTWORM LARVAE 67
Anorexia 62
Panting 56
Ataxia 56
Weight loss 55
Other abnormal test result NOS 54
Most Referenced Drugs
Milbemycin Oxime + Spinosad 1,357
Spinosad 836
Pyrantel Pamoate;Sarolaner 251
Moxidectin 246
Milbemycin Oxime + Praziquantel 169
Ivermectin 123
Fluralaner Chew Tablets 105
Sarolaner 93
Oclacitinib Maleate 89
Carprofen 86
Bedinvetmab 67
Milbemycin Oxime 64
Ivermectin + Pyrantel As Pamoate Salt 50
Selamectin 49
Melarsomine Dihydrochloride 38
Outcome Breakdown
Recovered/Normal
1,928 (56.0%)
Ongoing
726 (21.1%)
Outcome Unknown
535 (15.5%)
Recovered with Sequela
187 (5.4%)
Died
36 (1.0%)
Euthanized
29 (0.8%)
Gender Distribution
Female 1,764 (51.3%)
Male 1,639 (47.7%)
Unknown 31 (0.9%)
Mixed 5 (0.1%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 26 | |
| 2011 | 625 | |
| 2012 | 1,165 | |
| 2013 | 101 | |
| 2014 | 100 | |
| 2015 | 103 | |
| 2016 | 95 | |
| 2017 | 142 | |
| 2018 | 139 | |
| 2019 | 178 | |
| 2020 | 171 | |
| 2021 | 180 | |
| 2022 | 98 | |
| 2023 | 112 | |
| 2024 | 130 | |
| 2025 | 74 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #56 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.