Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
2,187
Total Reports
85
Deaths Reported
390.0%
Death Rate
6.0 yr
Avg Age at Report
Average weight at time of report: 21.6 kg (47.6 lbs)
Top Reported Reactions
Vomiting 317
Lethargy (see also Central nervous system depression in 'Neurological') 193
Lack of efficacy (endoparasite) - hookworm 173
Diarrhoea 157
Lack of efficacy - NOS 143
Emesis 132
Digestive tract disorder NOS 131
Seizure NOS 96
Lack of efficacy (ectoparasite) - tick NOS 93
INEFFECTIVE, HEARTWORM LARVAE 92
Lack of efficacy (ectoparasite) - flea 85
Lack of efficacy (bacteria) - NOS 84
Other abnormal test result NOS 75
Lack of efficacy (bacteria) - Borrelia 75
Lack of efficacy (endoparasite) - heartworm 73
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 347
Afoxolaner 246
Milbemycin Oxime + Spinosad 234
Pyrantel Pamoate;Sarolaner 140
Fluralaner Chew Tablets 123
Oclacitinib Maleate 93
Trilostane 92
Fluralaner 13.64% 12-Week Chew 84
Moxidectin 72
Milbemycin Oxime + Praziquantel 72
Spinosad 63
Sarolaner 57
Carprofen 48
Bedinvetmab 39
Lufenuron + Milbemycin Oxime 38
Outcome Breakdown
Outcome Unknown
828 (37.8%)
Recovered/Normal
616 (28.1%)
Ongoing
574 (26.2%)
Recovered with Sequela
87 (4.0%)
Euthanized
56 (2.6%)
Died
29 (1.3%)
Gender Distribution
Female 1,103 (50.4%)
Male 1,050 (48.0%)
Unknown 30 (1.4%)
Mixed 4 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 3 | |
| 2011 | 56 | |
| 2012 | 169 | |
| 2013 | 142 | |
| 2014 | 164 | |
| 2015 | 182 | |
| 2016 | 171 | |
| 2017 | 186 | |
| 2018 | 163 | |
| 2019 | 177 | |
| 2020 | 127 | |
| 2021 | 139 | |
| 2022 | 135 | |
| 2023 | 126 | |
| 2024 | 159 | |
| 2025 | 88 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #78 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.