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Breed profile · FDA CVM July 2026 extract

Collie - Border adverse-event record

Adverse-event filings for Collie - Border (Dog) in the FDA Center for Veterinary Medicine openFDA extract. Browse dog breeds, reactions, and outcomes below.

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#19 of 510
by report volume (all breeds)
10,130
FDA CVM reports on file
4.3%
death-coded share of reports
#164 of 275
by death-coded share (≥50 reports)

How the 10,130 reports break down

By recorded gender -- every report on file for Collie - Border, no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 776 582 388 194 0 2019 2020 2021 2022 2023 2024 2025 2026 Reports filed Death-coded reports
Annual report volume for Collie - Border drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Collie - Border ranks #19 of 510 by total reports (10,130) and #164 of 275 by death-coded share (4.3%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#19
This breed, reports of 510
#164
This breed, death share of 275

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Collie - Border has 10,130 reports now versus 10,003 in that prior snapshot: 127 more (1.3%).

Report change
+127
Death-coded reports
+3
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Collie - Border changes

Total Reports

10,130

Highest-reported breed

Deaths Reported

437

of 10,130 reports

Death-coded share of reports

4.3%

Below-median death-coded share

Avg Age at Report

5.8 yr

21.6 kg avg weight

Breed Safety Scorecard

C- (50/100)

A weighted composite across 4 of 4 dimensions, each benchmarked against every tracked breed with at least 200 reports (n=185). Dimensions with insufficient data drop out and their weight redistributes to the rest, so a missing input never silently deflates the score.

Death rate C
4.3%

Share of reports coded as a fatality

Euthanasia rate D
2.3%

Share of reports resulting in euthanasia

Full recovery rate D
26.6%

Share of reports coded "Recovered/Normal"

5-year trend C-
+4%

Change in annual report volume over the last 5 complete years

Death-Coded Outcome Share

Collie - Border death-coded reports 4.3%
Cross-breed median

4.3% of 10,130 collie - border reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Where Collie - Border's death-coded share sits among indexed breeds

Death-coded share of FDA CVM reports, breeds with ≥50 reports (July 2026 extract)

4% 40th percentile Higher share than 40% of 275 indexed breeds

5%–10%: 1 indexed breeds (0%). This entry sits in this band. 20%–25%: 2 indexed breeds (1%). Above this entry. 25%–30%: 3 indexed breeds (1%). Above this entry. 30%–35%: 4 indexed breeds (1%). Above this entry. 35%–40%: 5 indexed breeds (2%). Above this entry. 40%–45%: 6 indexed breeds (2%). Above this entry. 45%–50%: 3 indexed breeds (1%). Above this entry. 50%–55%: 7 indexed breeds (3%). Above this entry. 55%–60%: 7 indexed breeds (3%). Above this entry. 60%–65%: 21 indexed breeds (8%). Above this entry. 65%–70%: 11 indexed breeds (4%). Above this entry. 70%–75%: 15 indexed breeds (5%). Above this entry. 75%–80%: 13 indexed breeds (5%). Above this entry. 80%–85%: 11 indexed breeds (4%). Above this entry. 85%–90%: 12 indexed breeds (4%). Above this entry. 90%–95%: 12 indexed breeds (4%). Above this entry. 95%–100%: 142 indexed breeds (52%). Above this entry. Collie - Border 5% 100% every breed with ≥50 FDA reports, bucketed by value

Each bar is a band; taller bars hold more indexed breeds. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.

Source FDA Center for Veterinary Medicine, openFDA adverse event extract (PlainBreed) · July 2026 extract

This histogram uses the same ≥50-report cohort as the highest death-coded share ranking. A higher share means more of this breed's reported events were death-coded, not a mortality rate for living animals.

Collie - Border among report-volume vs. death-rate peers

Every breed shown has at least 50 filed reports. Volume reflects how often a breed is reported, not how common it is; death rate is the share of a breed's own reports coded as a death outcome.

Source: FDA openFDA Animal & Veterinary Adverse Events database 2×2 strategic matrix plotting 30 entities by Total Reports (X) and Death Rate (%) (Y), with a crosshair dividing the plot into four quadrants. High volume, high death rateLow volume, high death rateHigh volume, low death rateLow volume, low death rate 020,00040,00060,00080,000100,000 0%5%10%15% Total Reports Death Rate (%) Collie - Border vs. all breeds, report volume and death-coded share Retriever - Labrador-93675, 3.7%Crossbred Canine/dog-70591, 3.2%Domestic Shorthair-65226, 7.2%Dog (unknown)-48820, 8.8%Retriever - Golden-35980, 3.7%Shepherd Dog - German-32220, 4.4%Chihuahua-31521, 4.2%Terrier - Yorkshire-24924, 3.7%Shih Tzu-24405, 3.6%Boxer (German Boxer)-19405, 4.4%Beagle-17970, 3.6%Pit Bull-17865, 3.1%Shepherd Dog - Australian-16274, 3.7%Terrier (unspecified)-14058, 3.1%Maltese-13940, 3.2%Dachshund (unspecified)-13512, 4.6%Cat (unknown)-13248, 9.3%Terrier - Jack Russell-10423, 3.7%Collie - Border-10130, 4.3%Siberian Husky-9811, 4.5%Domestic Longhair-9615, 7%Pug-9224, 5.2%Spitz - German Pomeranian-9086, 4.9%Terrier - Bull - American Pit-8769, 4.7%Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog)-7871, 3.6%Terrier - Boston-7737, 4.5%Spaniel - Cocker American-7640, 4%Domestic (unspecified)-7576, 13.4%Poodle (unspecified)-7534, 3.4%Schnauzer - Miniature-7513, 4.4%
Source: FDA openFDA Animal & Veterinary Adverse Events database
Average weight at time of report: 21.6 kg (47.6 lbs)

Top Reported Reactions

Vomiting 1,554
Lack of efficacy (endoparasite) - heartworm 864
Lethargy (see also Central nervous system depression in 'Neurological') 769
Diarrhoea 737
INEFFECTIVE, HEARTWORM LARVAE 730
Lack of efficacy - NOS 613
Lack of efficacy (endoparasite) - hookworm 612
Emesis 559
Seizure NOS 485
Lack of efficacy (ectoparasite) - flea 455
Digestive tract disorder NOS 341
Anorexia 302
Ataxia 279
Lack of efficacy (ectoparasite) - tick NOS 264
Other abnormal test result NOS 252

Most Referenced Drugs

Milbemycin Oxime + Spinosad 1,636
Ivermectin + Pyrantel As Pamoate Salt 1,331
Afoxolaner 734
Pyrantel Pamoate;Sarolaner 722
Milbemycin Oxime + Praziquantel 634
Moxidectin 503
Bedinvetmab 412
Fluralaner Chew Tablets 349
Spinosad 318
Carprofen 283
Fluralaner 13.64% 12-Week Chew 278
Sarolaner 213
Oclacitinib Maleate 195
Imidacloprid + Moxidectin 179
Grapiprant 178

Outcome Breakdown

Outcome Unknown
3,450 (35.7%)
Recovered/Normal
2,691 (27.8%)
Ongoing
2,619 (27.1%)
Recovered with Sequela
470 (4.9%)
Euthanized
235 (2.4%)
Died
202 (2.1%)

Gender Distribution

Female 5,334 (52.7%)
Male 4,571 (45.1%)
Unknown 193 (1.9%)
Mixed 32 (0.3%)

Reports by Year

Year Reports Trend
2010 260
2011 317
2012 542
2013 597
2014 617
2015 766
2016 746
2017 781
2018 705
2019 736
2020 687
2021 624
2022 579
2023 650
2024 776
2025 649
2026 98

Collie - Border: high-volume FDA adverse-event cohort

Signature read: 10,130 reports place Collie - Border in the upper third of breed filing volume (#19 of 510). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Collie - Border sits at #19 of 510 by report volume among all breeds and #17 of 298 among dog breeds, with 10,130 reports and 437 (4.3%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #164 of 275. Mean age at report: 5.8 years, average weight 21.6 kg (47.6 lbs).

Top reported signs: Vomiting (1,554), Lack of efficacy (endoparasite) - heartworm (864), Lethargy (see also Central nervous system depression in 'Neurological') (769). Most-referenced drug: Milbemycin Oxime + Spinosad (1,636 reports), followed by Ivermectin + Pyrantel As Pamoate Salt (1,331) and Afoxolaner (734).

Outcome coding on 9,667 status-recorded reports is dominated by Outcome Unknown (35.7%). Annual submissions ranged 98-2,026 across 17 years on file.

Collie - Border Reporting Concentration Profile

Collie - Border is a high-volume FDA CVM cohort (10,130 reports) - enough filings to measure how concentrated the reaction and drug mix is, not just the headline totals. Across 20 named reaction terms in the stored top list, the leading three (Vomiting, Lack of efficacy (endoparasite) - heartworm, Lethargy (see also Central nervous system depression in 'Neurological')) account for 32.0% of listed reaction mentions. The Herfindahl index on that list is 0.071 (1.0 = a single reaction owns every mention; lower = a broader clinical mix).

On the drug side, 20 referenced products appear in the top list; the leading three (Milbemycin Oxime + Spinosad, Ivermectin + Pyrantel As Pamoate Salt, Afoxolaner) cover 42.2% of those mentions. That multi-product footprint is the profile thin-report breeds cannot show - their pages stop at a short bar list because the sample cannot support a concentration read.

Outcome coding on 9,667 status-recorded filings splits roughly 4.5% severe (died or euthanized - 437 reports) versus 32.7% recovered or recovered-with-sequela (3,161). Read that split next to the 4.3% death-coded share above - both track reporting severity bias in a popular breed, not a proven mortality rate.

Peak filing year was 2017 (781 reports); the lightest year on file was 2026 (98). From 2024 to 2025, annual volume fell 16.4% (776 → 649). Year-to-year swings at this volume usually track product launches, owner awareness, and reporting campaigns more than sudden breed-health shocks.

Dog Breeds With a Similar Report Volume

Showing 6 of 297 dog breeds in our dataset, ranked by closest report volume.

Terrier - Jack Russell
10,423 reports · 3.7% death-coded
Siberian Husky
9,811 reports · 4.5% death-coded
Pug
9,224 reports · 5.2% death-coded
Spitz - German Pomeranian
9,086 reports · 4.9% death-coded
Terrier - Bull - American Pit
8,769 reports · 4.7% death-coded
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog)
7,871 reports · 3.6% death-coded

Nationwide breeds with similar profiles

High-volume peer sets for Collie - Border drawn from openFDA outside the Dog family so the neighborhoods are not species containment (the similar-volume list above stays within species).

Similar death-coded share

Nearest other-species breeds with ≥50 reports (4.3% death-coded here).

Siberian 4.2% · Cat Bengal 4.6% · Cat Scottish Fold Longhair 4.8% · Cat British cat 3.8% · Cat

Similar average weight

Nearest other-species breeds by reported average weight (21.6 kg here).

Crossbred Caprine/goat 21.7 kg · Goat Pygmy 20.3 kg · Goat Mixed (Sheep) 24.9 kg · Sheep Wild cat 14.5 kg · Cat

What to do with this dog

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve Collie - Border? ▼
There are 10,130 adverse event reports involving Collie - Border in the FDA database, of which 437 were death-coded (4.3% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Collie - Border ranks #19 of 510 by report volume among all breeds PlainBreed indexes (#17 of 298 among dog breeds).
Where does Collie - Border sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Collie - Border is #19 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Dog, it is #17 of 298. Among breeds with at least 50 reports, its death-coded share ranks #164 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Collie - Border? ▼
The most commonly reported adverse reactions for Collie - Border are Vomiting (1,554 reports), Lack of efficacy (endoparasite) - heartworm (864 reports), Lethargy (see also Central nervous system depression in 'Neurological') (769 reports), Diarrhoea (737 reports), INEFFECTIVE, HEARTWORM LARVAE (730 reports).
What drugs are most frequently associated with Collie - Border adverse events? ▼
The drugs most frequently referenced in Collie - Border adverse event reports are Milbemycin Oxime + Spinosad (1,636 reports), Ivermectin + Pyrantel As Pamoate Salt (1,331 reports), Afoxolaner (734 reports), Pyrantel Pamoate;Sarolaner (722 reports), Milbemycin Oxime + Praziquantel (634 reports).
What is the average age of Collie - Border in adverse event reports? ▼
The average age of Collie - Border at the time of adverse event reports is 5.8 years, with an average weight of 21.6 kg (47.6 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Collie - Border (Dog), extract as of July 2026 extract. 10,130 reports · 437 death-coded (4.3% of reports, not a mortality rate) · #19 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →