Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
9,801
Total Reports
419
Deaths Reported
430.0%
Death Rate
5.8 yr
Avg Age at Report
Average weight at time of report: 21.6 kg (47.6 lbs)
Top Reported Reactions
Vomiting 1,524
Lack of efficacy (endoparasite) - heartworm 827
Lethargy (see also Central nervous system depression in 'Neurological') 769
INEFFECTIVE, HEARTWORM LARVAE 730
Diarrhoea 712
Lack of efficacy - NOS 598
Lack of efficacy (endoparasite) - hookworm 591
Emesis 558
Seizure NOS 460
Lack of efficacy (ectoparasite) - flea 438
Digestive tract disorder NOS 340
Anorexia 299
Ataxia 262
Lack of efficacy (ectoparasite) - tick NOS 250
Other abnormal test result NOS 240
Most Referenced Drugs
Milbemycin Oxime + Spinosad 1,629
Ivermectin + Pyrantel As Pamoate Salt 1,305
Afoxolaner 716
Pyrantel Pamoate;Sarolaner 649
Milbemycin Oxime + Praziquantel 619
Moxidectin 481
Bedinvetmab 366
Fluralaner Chew Tablets 349
Spinosad 318
Carprofen 269
Fluralaner 13.64% 12-Week Chew 251
Sarolaner 208
Oclacitinib Maleate 188
Selamectin 172
Imidacloprid + Moxidectin 171
Outcome Breakdown
Outcome Unknown
3,349 (35.9%)
Recovered/Normal
2,639 (28.3%)
Ongoing
2,462 (26.4%)
Recovered with Sequela
469 (5.0%)
Euthanized
221 (2.4%)
Died
198 (2.1%)
Gender Distribution
Female 5,155 (52.6%)
Male 4,426 (45.2%)
Unknown 189 (1.9%)
Mixed 31 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 260 | |
| 2011 | 317 | |
| 2012 | 542 | |
| 2013 | 597 | |
| 2014 | 616 | |
| 2015 | 766 | |
| 2016 | 746 | |
| 2017 | 780 | |
| 2018 | 705 | |
| 2019 | 736 | |
| 2020 | 687 | |
| 2021 | 623 | |
| 2022 | 577 | |
| 2023 | 647 | |
| 2024 | 763 | |
| 2025 | 439 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #19 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.