Collie - Border — FDA Adverse Event Profile

Collie - Border Pet Health Insights

Across the FDA Center for Veterinary Medicine adverse event database, Collie - Border accounts for 9,801 submitted reports and currently ranks #19 by report volume within the dog population. Of those reports, 419 involved a death outcome — a 430.0% case-fatality figure calculated directly from the underlying FDA records rather than from external mortality studies. The mean age at time of reporting is 5.8 years, with an average recorded body weight of 21.6 kg (47.6 lbs). These figures reflect the voluntary reporting pool only and should be read alongside breed popularity, veterinary access, and owner awareness — all of which shape how many events ever reach the FDA.

The most frequently reported clinical signs for Collie - Border are Vomiting (1,524 reports), Lack of efficacy (endoparasite) - heartworm (827 reports), Lethargy (see also Central nervous system depression in 'Neurological') (769 reports), together capturing a substantial share of the top-reaction traffic seen in this breed's record. On the product side, Milbemycin Oxime + Spinosad appears in 1,629 reports and is the single most-referenced drug, followed by Ivermectin + Pyrantel As Pamoate Salt (1,305) and Afoxolaner (716). Counts like these surface which therapeutic classes dominate the reporting stream — useful context when comparing reactions across breeds of the same dog species.

Outcome coding on the 9,338 reports with a recorded status is dominated by Outcome Unknown (35.9% of coded outcomes). Annual submission volume ranges from 2,010 to 2,025 reports across the 16 years on file, indicating the reporting trend is shaped as much by awareness cycles as by underlying clinical events. Because FDA adverse event reports describe correlation rather than causation, these numbers are most useful as a signal of where to ask further questions with a veterinarian — not as a standalone risk score for any individual dog.