Total Reports
9,801
FDA CVM filings
Dog /
FDA CVM · 2025 release 9,801 reports on file
Collie - Border - FDA Adverse Event Profile
Adverse-event records for Collie - Border (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Among dog breeds, Collie - Border is #19 by FDA report volume; 4.3% of its 9,801 reports (419) were death-coded.
- #19
- most-reported dog breed
- 4.3%
- death-coded report share
- 1,524
- Vomiting - top reaction
- 5.8 yr
- average age at report
Read report counts next to breed popularity: a bigger number often just means more owners and more vet visits.
Deaths Reported
419
of 9,801 reports
Death Rate
4.3%
death-coded share
Avg Age at Report
5.8 yr
21.6 kg avg weight
Death-Coded Outcome Share
Collie - Border death-coded reports 4.3%
Cross-breed median
4.3% of 9,801 collie - border reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 21.6 kg (47.6 lbs)
Top Reported Reactions
Vomiting 1,524
Lack of efficacy (endoparasite) - heartworm 827
Lethargy (see also Central nervous system depression in 'Neurological') 769
INEFFECTIVE, HEARTWORM LARVAE 730
Diarrhoea 712
Lack of efficacy - NOS 598
Lack of efficacy (endoparasite) - hookworm 591
Emesis 558
Seizure NOS 460
Lack of efficacy (ectoparasite) - flea 438
Digestive tract disorder NOS 340
Anorexia 299
Ataxia 262
Lack of efficacy (ectoparasite) - tick NOS 250
Other abnormal test result NOS 240
Most Referenced Drugs
Milbemycin Oxime + Spinosad 1,629
Ivermectin + Pyrantel As Pamoate Salt 1,305
Afoxolaner 716
Pyrantel Pamoate;Sarolaner 649
Milbemycin Oxime + Praziquantel 619
Moxidectin 481
Bedinvetmab 366
Fluralaner Chew Tablets 349
Spinosad 318
Carprofen 269
Fluralaner 13.64% 12-Week Chew 251
Sarolaner 208
Oclacitinib Maleate 188
Selamectin 172
Imidacloprid + Moxidectin 171
Outcome Breakdown
Outcome Unknown
3,349 (35.9%)
Recovered/Normal
2,639 (28.3%)
Ongoing
2,462 (26.4%)
Recovered with Sequela
469 (5.0%)
Euthanized
221 (2.4%)
Died
198 (2.1%)
Gender Distribution
Female 5,155 (52.6%)
Male 4,426 (45.2%)
Unknown 189 (1.9%)
Mixed 31 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 260 | |
| 2011 | 317 | |
| 2012 | 542 | |
| 2013 | 597 | |
| 2014 | 616 | |
| 2015 | 766 | |
| 2016 | 746 | |
| 2017 | 780 | |
| 2018 | 705 | |
| 2019 | 736 | |
| 2020 | 687 | |
| 2021 | 623 | |
| 2022 | 577 | |
| 2023 | 647 | |
| 2024 | 763 | |
| 2025 | 439 | |
Collie - Border Pet Health Insights
Collie - Border accounts for 9,801 FDA adverse event reports, ranking #19 by volume among dog breeds, with 419 reports (4.3%) coded as a death outcome. Mean age at report: 5.8 years, average weight 21.6 kg (47.6 lbs).
Top reported signs: Vomiting (1,524), Lack of efficacy (endoparasite) - heartworm (827), Lethargy (see also Central nervous system depression in 'Neurological') (769). Most-referenced drug: Milbemycin Oxime + Spinosad (1,629 reports), followed by Ivermectin + Pyrantel As Pamoate Salt (1,305) and Afoxolaner (716).
Outcome coding on 9,338 status-recorded reports is dominated by Outcome Unknown (35.9%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Dog Breeds With a Similar Report Volume
Siberian Husky
9,399 reports · 4.4% death rate
Terrier - Jack Russell
10,210 reports · 3.7% death rate
Pug
9,020 reports · 5.1% death rate
Spitz - German Pomeranian
8,853 reports · 5.0% death rate
Terrier - Bull - American Pit
8,232 reports · 4.5% death rate
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog)
7,541 reports · 3.6% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Collie - Border? ▼
There are 9,801 adverse event reports involving Collie - Border in the FDA database, with 419 reports involving death (4.3% death rate). Collie - Border ranks #19 by report volume.
What are the most common adverse reactions reported for Collie - Border? ▼
The most commonly reported adverse reactions for Collie - Border are Vomiting (1,524 reports), Lack of efficacy (endoparasite) - heartworm (827 reports), Lethargy (see also Central nervous system depression in 'Neurological') (769 reports), INEFFECTIVE, HEARTWORM LARVAE (730 reports), Diarrhoea (712 reports).
What drugs are most frequently associated with Collie - Border adverse events? ▼
The drugs most frequently referenced in Collie - Border adverse event reports are Milbemycin Oxime + Spinosad (1,629 reports), Ivermectin + Pyrantel As Pamoate Salt (1,305 reports), Afoxolaner (716 reports), Pyrantel Pamoate;Sarolaner (649 reports), Milbemycin Oxime + Praziquantel (619 reports).
What is the average age of Collie - Border in adverse event reports? ▼
The average age of Collie - Border at the time of adverse event reports is 5.8 years, with an average weight of 21.6 kg (47.6 lbs).
Does a high number of adverse event reports mean Collie - Border is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Collie - Border safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.