Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,261
Total Reports
91
Deaths Reported
720.0%
Death Rate
4.8 yr
Avg Age at Report
Average weight at time of report: 49.0 kg (108.0 lbs)
Top Reported Reactions
Vomiting 216
Diarrhoea 118
Lack of efficacy - NOS 84
Lack of efficacy (endoparasite) - hookworm 81
Lethargy (see also Central nervous system depression in 'Neurological') 80
Emesis 68
Anorexia 62
Death by euthanasia 53
INEFFECTIVE, HEARTWORM LARVAE 50
Digestive tract disorder NOS 45
Other abnormal test result NOS 40
Lack of efficacy (endoparasite) - heartworm 39
Not eating 38
Panting 37
Death 34
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 176
Milbemycin Oxime + Spinosad 157
Afoxolaner 107
Pyrantel Pamoate;Sarolaner 97
Carprofen 85
Milbemycin Oxime + Praziquantel 81
Oclacitinib Maleate 75
Bedinvetmab 72
Fluralaner Chew Tablets 65
Spinosad 49
Moxidectin 48
Fluralaner 13.64% 12-Week Chew 41
Selamectin 34
Grapiprant 34
Gabapentin 34
Outcome Breakdown
Outcome Unknown
356 (30.5%)
Ongoing
350 (29.9%)
Recovered/Normal
333 (28.5%)
Died
47 (4.0%)
Euthanized
45 (3.8%)
Recovered with Sequela
38 (3.3%)
Gender Distribution
Male 656 (52.0%)
Female 576 (45.7%)
Unknown 20 (1.6%)
Mixed 9 (0.7%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 43 | |
| 2011 | 73 | |
| 2012 | 72 | |
| 2013 | 50 | |
| 2014 | 93 | |
| 2015 | 83 | |
| 2016 | 109 | |
| 2017 | 104 | |
| 2018 | 79 | |
| 2019 | 72 | |
| 2020 | 80 | |
| 2021 | 65 | |
| 2022 | 74 | |
| 2023 | 88 | |
| 2024 | 124 | |
| 2025 | 52 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #96 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.