Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
441
Total Reports
52
Deaths Reported
1180.0%
Death Rate
5.5 yr
Avg Age at Report
Average weight at time of report: 51.7 kg (114.0 lbs)
Top Reported Reactions
Lethargy (see also Central nervous system depression in Neurological) 52
Vomiting 48
Lack of efficacy (endoparasite) - heartworm 42
Death by euthanasia 33
Lack of efficacy - NOS 31
Lack of efficacy (bacteria) - Borrelia 27
Seizure NOS 26
Diarrhoea 25
Intentional misuse 23
Lack of efficacy (endoparasite) - hookworm 22
Not eating 19
Death 18
Panting 17
Lack of efficacy (endoparasite) - roundworm NOS 16
Lack of efficacy (bacteria) - Anaplasma 16
Most Referenced Drugs
Bedinvetmab 125
Pyrantel Pamoate;Sarolaner 103
Moxidectin 36
Carprofen 31
Gabapentin 29
Fluralaner 13.64% 12-Week Chew 25
Ivermectin + Pyrantel As Pamoate Salt 23
Oclacitinib Maleate 23
Afoxolaner 19
Recombinant E. Coli Bl21;Recombinant E. Coli Ecl19 17
Milbemycin Oxime + Praziquantel 16
Afoxolaner 150Mg / Moxidectin 720Mcg / Pyrantel 300Mg Chewable Tablet 15
Amantadine 11
Prednisone 10
Grapiprant 9
Outcome Breakdown
Ongoing
222 (50.3%)
Outcome Unknown
109 (24.7%)
Recovered/Normal
58 (13.2%)
Euthanized
33 (7.5%)
Died
19 (4.3%)
Gender Distribution
Male 258 (58.5%)
Female 173 (39.2%)
Unknown 9 (2.0%)
Mixed 1 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2014 | 2 | |
| 2017 | 1 | |
| 2020 | 2 | |
| 2021 | 1 | |
| 2022 | 3 | |
| 2023 | 35 | |
| 2024 | 251 | |
| 2025 | 146 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #147 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.