Total Reports
569
Above-median volume
Dog /
Breed profile · FDA CVM July 2026 extract
Mastiff (unspecified) adverse-event record
Adverse-event filings for Mastiff (unspecified) (Dog) in the FDA Center for Veterinary Medicine openFDA extract. Browse dog breeds, reactions, and outcomes below.
- #134 of 510
- by report volume (all breeds)
- 569
- FDA CVM reports on file
- 9.8%
- death-coded share of reports
- #50 of 275
- by death-coded share (≥50 reports)
How the 569 reports break down
By recorded gender -- every report on file for Mastiff (unspecified), no filtering.
Annual report volume
Data updated September 2026
The verdict
According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Mastiff (unspecified) ranks #134 of 510 by total reports (569) and #50 of 275 by death-coded share (9.8%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).
- 93,675
- Retriever - Labrador reports (#1)
- 99.0%
- Atlantic Salmon (Salmo salar) death share (#1)
- #134
- This breed, reports of 510
- #50
- This breed, death share of 275
Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.
Release-over-release change
What changed in the latest FDA data snapshot
PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Mastiff (unspecified) has 569 reports now versus 522 in that prior snapshot: 47 more (9.0%).
- Report change
- +47
- Death-coded reports
- +3
- Death-coded share
- −0.3 pts
This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.
Subscribe to Mastiff (unspecified) changesDeaths Reported
56
of 569 reports
Death-coded share of reports
9.8%
High death-coded share
Avg Age at Report
5.3 yr
52.5 kg avg weight
Breed Safety Scorecard
F (6/100)
A weighted composite across 4 of 4 dimensions, each benchmarked against every tracked breed with at least 200 reports (n=185). Dimensions with insufficient data drop out and their weight redistributes to the rest, so a missing input never silently deflates the score.
Death rate F
9.8%
Share of reports coded as a fatality
Euthanasia rate F
6.3%
Share of reports resulting in euthanasia
Full recovery rate F
14.1%
Share of reports coded "Recovered/Normal"
5-year trend F
+23200%
Change in annual report volume over the last 5 complete years
Death-Coded Outcome Share
Mastiff (unspecified) death-coded reports 9.8%
Cross-breed median
9.8% of 569 mastiff (unspecified) reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 52.5 kg (115.8 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 64
Vomiting 58
Lethargy (see also Central nervous system depression in Neurological) 57
Lack of efficacy - NOS 40
Lack of efficacy (bacteria) - Borrelia 40
Death by euthanasia 36
Seizure NOS 33
Diarrhoea 32
Most Referenced Drugs
Pyrantel Pamoate;Sarolaner 139
Bedinvetmab 137
Moxidectin 48
Carprofen 43
Fluralaner 13.64% 12-Week Chew 42
Oclacitinib Maleate 35
Gabapentin 34
Ivermectin + Pyrantel As Pamoate Salt 32
Outcome Breakdown
Ongoing
290 (50.9%)
Outcome Unknown
144 (25.3%)
Recovered/Normal
80 (14.0%)
Euthanized
36 (6.3%)
Died
20 (3.5%)
Gender Distribution
Male 340 (59.8%)
Female 213 (37.4%)
Unknown 15 (2.6%)
Mixed 1 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2014 | 2 | |
| 2017 | 1 | |
| 2020 | 2 | |
| 2021 | 1 | |
| 2022 | 5 | |
| 2023 | 36 | |
| 2024 | 253 | |
| 2025 | 233 | |
| 2026 | 36 | |
Mastiff (unspecified): high death-coded share in the FDA CVM extract
Signature read: Mastiff (unspecified)'s 9.8% death-coded share is in the upper third of the ≥50-report cohort (median 4.8%). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Mastiff (unspecified) sits at #134 of 510 by report volume among all breeds and #111 of 298 among dog breeds, with 569 reports and 56 (9.8%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #50 of 275. Mean age at report: 5.3 years, average weight 52.5 kg (115.8 lbs).
Top reported signs: Lack of efficacy (endoparasite) - heartworm (64), Vomiting (58), Lethargy (see also Central nervous system depression in Neurological) (57). Most-referenced drug: Pyrantel Pamoate;Sarolaner (139 reports), followed by Bedinvetmab (137) and Moxidectin (48).
Outcome coding on 570 status-recorded reports is dominated by Ongoing (50.9%). Annual submissions ranged 1-2,026 across 9 years on file.
Dog Breeds With a Similar Report Volume
Showing 6 of 297 dog breeds in our dataset, ranked by closest report volume.
Nationwide breeds with similar profiles
High-volume peer sets for Mastiff (unspecified) drawn from openFDA outside the Dog family so the neighborhoods are not species containment (the similar-volume list above stays within species).
Similar death-coded share
Nearest other-species breeds with ≥50 reports (9.8% death-coded here).
Similar average weight
Nearest other-species breeds by reported average weight (52.5 kg here).
What to do with this dog
- Compare Mastiff (unspecified)'s report volume and death-coded share against similar-volume breeds nationwide. See similar breeds
- Read how death-coded share differs from a mortality rate before drawing conclusions. Breed-specific risks guide
- Browse every dog breed we track for comparison. All dog breeds
A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.
Frequently Asked Questions
How many FDA adverse event reports involve Mastiff (unspecified)? ▼
There are 569 adverse event reports involving Mastiff (unspecified) in the FDA database, of which 56 were death-coded (9.8% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Mastiff (unspecified) ranks #134 of 510 by report volume among all breeds PlainBreed indexes (#111 of 298 among dog breeds).
Where does Mastiff (unspecified) sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Mastiff (unspecified) is #134 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Dog, it is #111 of 298. Among breeds with at least 50 reports, its death-coded share ranks #50 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Mastiff (unspecified)? ▼
The most commonly reported adverse reactions for Mastiff (unspecified) are Lack of efficacy (endoparasite) - heartworm (64 reports), Vomiting (58 reports), Lethargy (see also Central nervous system depression in Neurological) (57 reports), Lack of efficacy - NOS (40 reports), Lack of efficacy (bacteria) - Borrelia (40 reports).
What drugs are most frequently associated with Mastiff (unspecified) adverse events? ▼
The drugs most frequently referenced in Mastiff (unspecified) adverse event reports are Pyrantel Pamoate;Sarolaner (139 reports), Bedinvetmab (137 reports), Moxidectin (48 reports), Carprofen (43 reports), Fluralaner 13.64% 12-Week Chew (42 reports).
What is the average age of Mastiff (unspecified) in adverse event reports? ▼
The average age of Mastiff (unspecified) at the time of adverse event reports is 5.3 years, with an average weight of 52.5 kg (115.8 lbs).
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.
Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025
openFDA Animal & Veterinary Adverse Events (FDA CVM) for Mastiff (unspecified) (Dog), extract as of July 2026 extract. 569 reports · 56 death-coded (9.8% of reports, not a mortality rate) · #134 of 510 by volume.
Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →