Total Reports
441
FDA CVM filings
Dog /
FDA CVM · 2025 release 441 reports on file
Mastiff (unspecified) - FDA Adverse Event Profile
Adverse-event records for Mastiff (unspecified) (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
With 441 reports on file, Mastiff (unspecified) sits at #147 among dog breeds by volume; death-coded share is 11.8% (52 reports).
- #147
- most-reported dog breed
- 11.8%
- death-coded report share
- 52
- Lethargy (see also Central nervous system depression in Neurological) - top reaction
- 5.5 yr
- average age at report
Higher volume usually means a more popular breed, not a riskier one, compare against how common the breed is.
Deaths Reported
52
of 441 reports
Death Rate
11.8%
death-coded share
Avg Age at Report
5.5 yr
51.7 kg avg weight
Death-Coded Outcome Share
Mastiff (unspecified) death-coded reports 11.8%
Cross-breed median
11.8% of 441 mastiff (unspecified) reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 51.7 kg (114.0 lbs)
Top Reported Reactions
Lethargy (see also Central nervous system depression in Neurological) 52
Vomiting 48
Lack of efficacy (endoparasite) - heartworm 42
Death by euthanasia 33
Lack of efficacy - NOS 31
Lack of efficacy (bacteria) - Borrelia 27
Seizure NOS 26
Diarrhoea 25
Most Referenced Drugs
Bedinvetmab 125
Pyrantel Pamoate;Sarolaner 103
Moxidectin 36
Carprofen 31
Gabapentin 29
Fluralaner 13.64% 12-Week Chew 25
Ivermectin + Pyrantel As Pamoate Salt 23
Oclacitinib Maleate 23
Outcome Breakdown
Ongoing
222 (50.3%)
Outcome Unknown
109 (24.7%)
Recovered/Normal
58 (13.2%)
Euthanized
33 (7.5%)
Died
19 (4.3%)
Gender Distribution
Male 258 (58.5%)
Female 173 (39.2%)
Unknown 9 (2.0%)
Mixed 1 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2014 | 2 | |
| 2017 | 1 | |
| 2020 | 2 | |
| 2021 | 1 | |
| 2022 | 3 | |
| 2023 | 35 | |
| 2024 | 251 | |
| 2025 | 146 | |
Mastiff (unspecified) Pet Health Insights
Mastiff (unspecified) accounts for 441 FDA adverse event reports, ranking #147 by volume among dog breeds, with 52 reports (11.8%) coded as a death outcome. Mean age at report: 5.5 years, average weight 51.7 kg (114.0 lbs).
Top reported signs: Lethargy (see also Central nervous system depression in Neurological) (52), Vomiting (48), Lack of efficacy (endoparasite) - heartworm (42). Most-referenced drug: Bedinvetmab (125 reports), followed by Pyrantel Pamoate;Sarolaner (103) and Moxidectin (36).
Outcome coding on 441 status-recorded reports is dominated by Ongoing (50.3%). Annual submissions ranged 2,014-2,025 across 8 years on file.
Dog Breeds With a Similar Report Volume
Terrier - Tibetan
439 reports · 2.7% death rate
Shepherd Dog - Anatolian
447 reports · 4.7% death rate
Basenji
452 reports · 5.5% death rate
Coonhound - Treeing Walker
455 reports · 2.9% death rate
Terrier - Fox Wire
426 reports · 5.2% death rate
Pointing Dog - German Wire-haired
468 reports · 4.1% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Mastiff (unspecified)? ▼
There are 441 adverse event reports involving Mastiff (unspecified) in the FDA database, with 52 reports involving death (11.8% death rate). Mastiff (unspecified) ranks #147 by report volume.
What are the most common adverse reactions reported for Mastiff (unspecified)? ▼
The most commonly reported adverse reactions for Mastiff (unspecified) are Lethargy (see also Central nervous system depression in Neurological) (52 reports), Vomiting (48 reports), Lack of efficacy (endoparasite) - heartworm (42 reports), Death by euthanasia (33 reports), Lack of efficacy - NOS (31 reports).
What drugs are most frequently associated with Mastiff (unspecified) adverse events? ▼
The drugs most frequently referenced in Mastiff (unspecified) adverse event reports are Bedinvetmab (125 reports), Pyrantel Pamoate;Sarolaner (103 reports), Moxidectin (36 reports), Carprofen (31 reports), Gabapentin (29 reports).
What is the average age of Mastiff (unspecified) in adverse event reports? ▼
The average age of Mastiff (unspecified) at the time of adverse event reports is 5.5 years, with an average weight of 51.7 kg (114.0 lbs).
Does a high number of adverse event reports mean Mastiff (unspecified) is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Mastiff (unspecified) safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.