Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
822
Total Reports
23
Deaths Reported
280.0%
Death Rate
6.2 yr
Avg Age at Report
Average weight at time of report: 7.4 kg (16.3 lbs)
Top Reported Reactions
Vomiting 213
Emesis 102
Lethargy (see also Central nervous system depression in 'Neurological') 89
Seizure NOS 62
Diarrhoea 61
Anorexia 39
Ataxia 39
Lack of efficacy (ectoparasite) - flea 38
Lack of efficacy (endoparasite) - hookworm 35
Lack of efficacy - NOS 33
Shaking 25
Behavioural disorder NOS 21
Elevated alanine aminotransferase (ALT) 20
INEFFECTIVE, HEARTWORM LARVAE 19
Hives (see also 'Skin') 19
Most Referenced Drugs
Milbemycin Oxime + Spinosad 173
Spinosad 82
Ivermectin + Pyrantel As Pamoate Salt 52
Moxidectin 49
Afoxolaner 31
Fluralaner Chew Tablets 28
Milbemycin Oxime + Praziquantel 26
Pyrantel Pamoate;Sarolaner 24
Sarolaner 21
Carprofen 20
Prednisone 19
Imidacloprid + Moxidectin 18
Maropitant Citrate 18
Ivermectin, Pyrantel 17
Fluralaner 13.64% 12-Week Chew 17
Outcome Breakdown
Recovered/Normal
344 (47.1%)
Outcome Unknown
197 (27.0%)
Ongoing
144 (19.7%)
Recovered with Sequela
22 (3.0%)
Euthanized
15 (2.1%)
Died
8 (1.1%)
Gender Distribution
Male 408 (49.6%)
Female 382 (46.5%)
Unknown 29 (3.5%)
Mixed 3 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 50 | |
| 2011 | 53 | |
| 2012 | 86 | |
| 2013 | 85 | |
| 2014 | 81 | |
| 2015 | 48 | |
| 2016 | 54 | |
| 2017 | 61 | |
| 2018 | 52 | |
| 2019 | 48 | |
| 2020 | 31 | |
| 2021 | 44 | |
| 2022 | 38 | |
| 2023 | 22 | |
| 2024 | 48 | |
| 2025 | 21 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #117 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.