Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
152
Total Reports
4
Deaths Reported
260.0%
Death Rate
6.5 yr
Avg Age at Report
Average weight at time of report: 8.0 kg (17.6 lbs)
Top Reported Reactions
Vomiting 32
Lethargy (see also Central nervous system depression in 'Neurological') 25
Emesis 16
Diarrhoea 15
Lack of efficacy (ectoparasite) - flea 14
Lack of efficacy (endoparasite) - hookworm 12
Lack of efficacy - NOS 10
Anorexia 7
Other abnormal test result NOS 6
Emesis (multiple) 6
Hyperkalaemia 5
Overdose 5
Facial swelling (see also 'Skin') 5
Elevated alanine aminotransferase (ALT) 5
Elevated serum alkaline phosphatase (SAP) 4
Most Referenced Drugs
Milbemycin Oxime + Spinosad 45
Trilostane 17
Spinosad 10
Moxidectin 10
Fluralaner Chew Tablets 10
Oclacitinib Maleate 8
Pyrantel Pamoate;Sarolaner 8
Fluralaner 13.64% 12-Week Chew 6
Sarolaner 5
Milbemycin Oxime + Praziquantel 5
Selamectin 4
Rabies Vaccine 4
Cyclosporine A 3
Carprofen 3
Ivermectin + Pyrantel As Pamoate Salt 3
Outcome Breakdown
Recovered/Normal
56 (36.8%)
Ongoing
48 (31.6%)
Outcome Unknown
41 (27.0%)
Recovered with Sequela
3 (2.0%)
Died
3 (2.0%)
Euthanized
1 (0.7%)
Gender Distribution
Female 75 (49.3%)
Male 73 (48.0%)
Unknown 4 (2.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 1 | |
| 2011 | 1 | |
| 2012 | 3 | |
| 2013 | 12 | |
| 2014 | 16 | |
| 2015 | 12 | |
| 2016 | 10 | |
| 2017 | 18 | |
| 2018 | 8 | |
| 2019 | 13 | |
| 2020 | 13 | |
| 2021 | 9 | |
| 2022 | 8 | |
| 2023 | 8 | |
| 2024 | 15 | |
| 2025 | 5 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #204 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.