Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
291
Total Reports
10
Deaths Reported
340.0%
Death Rate
4.9 yr
Avg Age at Report
Average weight at time of report: 25.7 kg (56.7 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - hookworm 73
Lack of efficacy (endoparasite) - heartworm 41
Vomiting 27
Lethargy (see also Central nervous system depression in 'Neurological') 19
Diarrhoea 18
Digestive tract disorder NOS 15
Lack of efficacy - NOS 15
Anorexia 14
INEFFECTIVE, HOOKS 13
Seizure NOS 9
INEFFECTIVE, HEARTWORM LARVAE 8
Emesis 7
Bloody diarrhoea 7
Death by euthanasia 7
Lack of efficacy (endoparasite) - roundworm NOS 7
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 74
Pyrantel Pamoate;Sarolaner 38
Afoxolaner 26
Milbemycin Oxime + Spinosad 15
Fluralaner Chew Tablets 15
Moxidectin 14
Milbemycin Oxime + Praziquantel 13
Melarsomine Dihydrochloride 10
Oclacitinib Maleate 7
Milbemycin Oxime, Lufenuron 7
Imidacloprid + Moxidectin 6
Lufenuron + Milbemycin Oxime 6
Maropitant Citrate 6
Ivermectin + Pyrantel 6
Milbemycin/Lufenuron Tablets 6
Outcome Breakdown
Outcome Unknown
125 (42.8%)
Ongoing
97 (33.2%)
Recovered/Normal
51 (17.5%)
Recovered with Sequela
9 (3.1%)
Euthanized
7 (2.4%)
Died
3 (1.0%)
Gender Distribution
Male 150 (51.5%)
Female 137 (47.1%)
Unknown 2 (0.7%)
Mixed 2 (0.7%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 1 | |
| 2011 | 2 | |
| 2012 | 10 | |
| 2013 | 5 | |
| 2014 | 11 | |
| 2015 | 17 | |
| 2016 | 15 | |
| 2017 | 15 | |
| 2018 | 16 | |
| 2019 | 25 | |
| 2020 | 27 | |
| 2021 | 30 | |
| 2022 | 34 | |
| 2023 | 30 | |
| 2024 | 29 | |
| 2025 | 24 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #166 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.