Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
64
Total Reports
2
Deaths Reported
310.0%
Death Rate
5.6 yr
Avg Age at Report
Average weight at time of report: 5.4 kg (11.9 lbs)
Top Reported Reactions
Emesis 11
Lethargy (see also Central nervous system depression in 'Neurological') 9
Lack of efficacy (ectoparasite) - flea 8
Vomiting 7
Diarrhoea 6
Lack of efficacy (flea) 6
Disorientation 4
Ataxia 3
Seizure NOS 3
Nausea 3
Itching 3
Trembling 3
Anorexia 3
UNPALATABLE 2
Reddening of the skin 2
Most Referenced Drugs
Milbemycin Oxime + Spinosad 24
Nitenpyram 10
Spinosad 6
(S)-Methoprene + Permethrin 5
Flea Product (Unknown) 5
Lufenuron + Milbemycin Oxime 4
Levothyroxine Sodium 3
Fluralaner 13.64% 12-Week Chew 3
Prednisolone Trimeprazine Tartrate 2
Clomipramine Hydrochloride 2
Milbemycin Oxime, Lufenuron 2
Milbemycin Oxime + Praziquantel 2
Ivermectin + Pyrantel 2
Florfenicol, Terbinafine, Betamethasone Acetate 2
Flumethrin-Imidacloprid 2
Outcome Breakdown
Recovered/Normal
30 (46.9%)
Outcome Unknown
19 (29.7%)
Ongoing
11 (17.2%)
Recovered with Sequela
2 (3.1%)
Died
1 (1.6%)
Euthanized
1 (1.6%)
Gender Distribution
Male 33 (51.6%)
Female 26 (40.6%)
Unknown 5 (7.8%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 1 | |
| 2011 | 3 | |
| 2012 | 5 | |
| 2013 | 10 | |
| 2014 | 10 | |
| 2015 | 5 | |
| 2016 | 1 | |
| 2017 | 6 | |
| 2018 | 1 | |
| 2019 | 7 | |
| 2020 | 2 | |
| 2021 | 3 | |
| 2022 | 2 | |
| 2023 | 4 | |
| 2024 | 1 | |
| 2025 | 3 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #258 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.