Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
2,744
Total Reports
118
Deaths Reported
430.0%
Death Rate
5.3 yr
Avg Age at Report
Average weight at time of report: 13.3 kg (29.3 lbs)
Top Reported Reactions
Vomiting 647
Emesis 373
Lethargy (see also Central nervous system depression in 'Neurological') 244
Diarrhoea 225
Lack of efficacy (ectoparasite) - flea 173
Lack of efficacy (endoparasite) - hookworm 135
Lack of efficacy - NOS 124
Lack of efficacy (endoparasite) - heartworm 105
Anorexia 94
INEFFECTIVE, HEARTWORM LARVAE 87
Seizure NOS 82
Death 60
Lack of efficacy (bacteria) - Borrelia 59
Other abnormal test result NOS 58
Elevated alanine aminotransferase (ALT) 57
Most Referenced Drugs
Milbemycin Oxime + Spinosad 820
Pyrantel Pamoate;Sarolaner 317
Spinosad 264
Moxidectin 188
Milbemycin Oxime + Praziquantel 172
Carprofen 101
Oclacitinib Maleate 98
Sarolaner 86
Fluralaner 13.64% 12-Week Chew 83
Bedinvetmab 80
Lotilaner 73
Ivermectin, Pyrantel 72
Selamectin 53
Maropitant Citrate 51
Nitenpyram 44
Outcome Breakdown
Recovered/Normal
930 (38.3%)
Ongoing
786 (32.4%)
Outcome Unknown
526 (21.7%)
Died
66 (2.7%)
Recovered with Sequela
66 (2.7%)
Euthanized
52 (2.1%)
Gender Distribution
Male 1,368 (49.9%)
Female 1,310 (47.7%)
Unknown 56 (2.0%)
Mixed 10 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 162 | |
| 2011 | 213 | |
| 2012 | 235 | |
| 2013 | 201 | |
| 2014 | 195 | |
| 2015 | 139 | |
| 2016 | 125 | |
| 2017 | 159 | |
| 2018 | 144 | |
| 2019 | 157 | |
| 2020 | 168 | |
| 2021 | 138 | |
| 2022 | 151 | |
| 2023 | 184 | |
| 2024 | 207 | |
| 2025 | 166 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #66 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.