Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,083
Total Reports
55
Deaths Reported
510.0%
Death Rate
5.4 yr
Avg Age at Report
Average weight at time of report: 37.3 kg (82.2 lbs)
Top Reported Reactions
Vomiting 178
Lethargy (see also Central nervous system depression in 'Neurological') 126
Emesis 92
Diarrhoea 79
INEFFECTIVE, HEARTWORM LARVAE 77
Lack of efficacy (endoparasite) - heartworm 65
Lack of efficacy - NOS 47
Lack of efficacy (ectoparasite) - flea 46
Seizure NOS 45
Other abnormal test result NOS 42
Anorexia 41
Behavioural disorder NOS 41
Ataxia 31
Lack of efficacy (bacteria) - Borrelia 30
Panting 29
Most Referenced Drugs
Milbemycin Oxime + Spinosad 217
Ivermectin + Pyrantel As Pamoate Salt 98
Afoxolaner 83
Spinosad 79
Pyrantel Pamoate;Sarolaner 58
Carprofen 44
Fluralaner Chew Tablets 44
Oclacitinib Maleate 41
Bedinvetmab 41
Moxidectin 34
Milbemycin Oxime + Praziquantel 33
Fluralaner 13.64% 12-Week Chew 27
Selamectin 23
Grapiprant 20
Prednisone 19
Outcome Breakdown
Recovered/Normal
331 (32.6%)
Outcome Unknown
311 (30.6%)
Ongoing
266 (26.2%)
Recovered with Sequela
52 (5.1%)
Died
34 (3.3%)
Euthanized
21 (2.1%)
Gender Distribution
Male 566 (52.3%)
Female 493 (45.5%)
Unknown 17 (1.6%)
Mixed 7 (0.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 34 | |
| 2011 | 65 | |
| 2012 | 90 | |
| 2013 | 77 | |
| 2014 | 92 | |
| 2015 | 94 | |
| 2016 | 85 | |
| 2017 | 75 | |
| 2018 | 74 | |
| 2019 | 59 | |
| 2020 | 49 | |
| 2021 | 52 | |
| 2022 | 62 | |
| 2023 | 58 | |
| 2024 | 74 | |
| 2025 | 43 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #107 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.