Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
55
Total Reports
1
Deaths Reported
180.0%
Death Rate
3.8 yr
Avg Age at Report
Average weight at time of report: 40.9 kg (90.2 lbs)
Top Reported Reactions
Vomiting 14
Diarrhoea 11
Emesis 5
Lack of efficacy (endoparasite) - heartworm 5
Lethargy (see also Central nervous system depression in 'Neurological') 3
Seizure NOS 3
Anorexia 3
Ataxia 3
Cardiac disorder NOS 2
INEFFECTIVE, HEARTWORM LARVAE 2
Weight loss 2
Emesis (multiple) 2
Bloody diarrhoea 2
Hives (see also 'Skin') 2
Alopecia local 2
Most Referenced Drugs
Milbemycin Oxime + Spinosad 14
Milbemycin Oxime + Praziquantel 8
Moxidectin 8
Ivermectin + Pyrantel As Pamoate Salt 7
Carprofen 5
Bedinvetmab 4
Maropitant Citrate 3
Pyrantel Pamoate;Sarolaner 3
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 2
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 2
Spinosad 2
Sucralfate 2
Metronidazole 2
Tramadol 2
Firocoxib 1
Outcome Breakdown
Ongoing
20 (36.4%)
Outcome Unknown
17 (30.9%)
Recovered/Normal
16 (29.1%)
Recovered with Sequela
1 (1.8%)
Died
1 (1.8%)
Gender Distribution
Male 28 (50.9%)
Female 27 (49.1%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2012 | 8 | |
| 2013 | 4 | |
| 2014 | 1 | |
| 2015 | 3 | |
| 2016 | 1 | |
| 2017 | 5 | |
| 2018 | 4 | |
| 2019 | 5 | |
| 2020 | 1 | |
| 2021 | 2 | |
| 2022 | 6 | |
| 2023 | 4 | |
| 2024 | 9 | |
| 2025 | 2 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #268 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.