Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,200
Total Reports
41
Deaths Reported
340.0%
Death Rate
5.4 yr
Avg Age at Report
Average weight at time of report: 13.4 kg (29.5 lbs)
Top Reported Reactions
Vomiting 239
Lack of efficacy (endoparasite) - hookworm 138
Digestive tract disorder NOS 135
Diarrhoea 91
Lethargy (see also Central nervous system depression in 'Neurological') 87
INEFFECTIVE, HEARTWORM LARVAE 72
Lack of efficacy (endoparasite) - heartworm 71
INEFFECTIVE, ASCARIDS NOS 59
Lack of efficacy - NOS 58
Emesis 49
Lack of efficacy (endoparasite) - roundworm NOS 49
Lack of efficacy (ectoparasite) - flea 41
Other abnormal test result NOS 39
Cardiac disorder NOS 37
INEFFECTIVE, HOOKS 37
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 349
Afoxolaner 215
Milbemycin Oxime + Spinosad 88
Fluralaner Chew Tablets 74
Trilostane 45
Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg 45
Milbemycin Oxime + Praziquantel 24
Afoxolaner 37.5Mg / Moxidectin 180Mcg / Pyrantel 75Mg Chewable Tablet 24
Milbemycin Oxime, Lufenuron 22
Fluralaner 13.64% 12-Week Chew 21
Melarsomine Dihydrochloride Injection 20
Polysulfated Glycosaminoglycan 20
Carprofen 19
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 18
Spinosad 18
Outcome Breakdown
Outcome Unknown
586 (48.8%)
Recovered/Normal
346 (28.8%)
Ongoing
164 (13.7%)
Recovered with Sequela
64 (5.3%)
Euthanized
25 (2.1%)
Died
16 (1.3%)
Gender Distribution
Male 609 (50.7%)
Female 564 (47.0%)
Unknown 24 (2.0%)
Mixed 3 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2011 | 17 | |
| 2012 | 63 | |
| 2013 | 74 | |
| 2014 | 69 | |
| 2015 | 105 | |
| 2016 | 122 | |
| 2017 | 112 | |
| 2018 | 91 | |
| 2019 | 84 | |
| 2020 | 98 | |
| 2021 | 62 | |
| 2022 | 80 | |
| 2023 | 64 | |
| 2024 | 103 | |
| 2025 | 56 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #102 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.