Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
3,074
Total Reports
150
Deaths Reported
490.0%
Death Rate
7.0 yr
Avg Age at Report
Average weight at time of report: 13.9 kg (30.6 lbs)
Top Reported Reactions
Vomiting 502
Lethargy (see also Central nervous system depression in 'Neurological') 291
Diarrhoea 262
Lack of efficacy - NOS 208
Lack of efficacy (endoparasite) - hookworm 187
Seizure NOS 173
Emesis 170
Lack of efficacy (endoparasite) - heartworm 120
Decreased appetite 107
Other abnormal test result NOS 106
Anorexia 98
INEFFECTIVE, HEARTWORM LARVAE 97
Lack of efficacy (bacteria) - Borrelia 96
Death by euthanasia 91
Lack of efficacy (ectoparasite) - flea 86
Most Referenced Drugs
Pyrantel Pamoate;Sarolaner 438
Trilostane 404
Oclacitinib Maleate 313
Ivermectin + Pyrantel As Pamoate Salt 281
Milbemycin Oxime + Spinosad 266
Moxidectin 246
Afoxolaner 163
Sarolaner 160
Bedinvetmab 149
Carprofen 130
Selamectin 94
Spinosad 80
Anti-Il31 Mab Mcs Lot #1283563 76
Maropitant Citrate 69
Gabapentin 51
Outcome Breakdown
Ongoing
1,069 (34.7%)
Outcome Unknown
984 (32.0%)
Recovered/Normal
794 (25.8%)
Euthanized
90 (2.9%)
Recovered with Sequela
80 (2.6%)
Died
60 (1.9%)
Gender Distribution
Female 1,524 (49.6%)
Male 1,484 (48.3%)
Unknown 55 (1.8%)
Mixed 11 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 3 | |
| 2011 | 33 | |
| 2012 | 134 | |
| 2013 | 158 | |
| 2014 | 236 | |
| 2015 | 245 | |
| 2016 | 258 | |
| 2017 | 208 | |
| 2018 | 210 | |
| 2019 | 207 | |
| 2020 | 209 | |
| 2021 | 193 | |
| 2022 | 226 | |
| 2023 | 237 | |
| 2024 | 323 | |
| 2025 | 194 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #60 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.