Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
330
Total Reports
11
Deaths Reported
330.0%
Death Rate
4.2 yr
Avg Age at Report
Average weight at time of report: 28.3 kg (62.4 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 70
Vomiting 36
Lack of efficacy (endoparasite) - hookworm 35
Lack of efficacy - NOS 26
Lethargy (see also Central nervous system depression in 'Neurological') 21
Emesis 17
INEFFECTIVE, HEARTWORM LARVAE 14
Other abnormal test result NOS 12
Lack of efficacy (ectoparasite) - flea 11
Seizure NOS 11
Lethargy (see also Central nervous system depression in Neurological) 11
Decreased appetite 10
Diarrhoea 10
INEFFECTIVE, HOOKS 9
Elevated alanine aminotransferase (ALT) 9
Most Referenced Drugs
Milbemycin Oxime + Spinosad 70
Milbemycin Oxime + Praziquantel 56
Moxidectin 52
Pyrantel Pamoate;Sarolaner 37
Ivermectin + Pyrantel As Pamoate Salt 23
Melarsomine Dihydrochloride 18
Oclacitinib Maleate 15
Trilostane 13
Sarolaner 11
Lotilaner 11
Doxycycline 10
Afoxolaner 10
Carprofen 9
Prednisone 9
Selamectin 8
Outcome Breakdown
Ongoing
129 (39.1%)
Outcome Unknown
112 (33.9%)
Recovered/Normal
65 (19.7%)
Recovered with Sequela
13 (3.9%)
Died
6 (1.8%)
Euthanized
5 (1.5%)
Gender Distribution
Male 174 (52.7%)
Female 153 (46.4%)
Unknown 2 (0.6%)
Mixed 1 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2011 | 1 | |
| 2012 | 14 | |
| 2013 | 13 | |
| 2014 | 14 | |
| 2015 | 19 | |
| 2016 | 9 | |
| 2017 | 23 | |
| 2018 | 23 | |
| 2019 | 30 | |
| 2020 | 26 | |
| 2021 | 34 | |
| 2022 | 27 | |
| 2023 | 40 | |
| 2024 | 39 | |
| 2025 | 18 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #162 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.