Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
489
Total Reports
7
Deaths Reported
140.0%
Death Rate
3.8 yr
Avg Age at Report
Average weight at time of report: 22.7 kg (50.1 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 194
INEFFECTIVE, HEARTWORM LARVAE 63
Vomiting 58
Lack of efficacy (endoparasite) - hookworm 28
Lack of efficacy - NOS 23
Emesis 23
Lethargy (see also Central nervous system depression in 'Neurological') 18
Cardiac disorder NOS 14
Drug dose administration interval too long 12
Overdose 12
Lack of efficacy (ectoparasite) - flea 11
Diarrhoea 10
INEFFECTIVE, HOOKS 10
Lack of efficacy (endoparasite) - whipworm 10
Other abnormal test result NOS 8
Most Referenced Drugs
Milbemycin Oxime + Spinosad 129
Moxidectin 95
Ivermectin + Pyrantel As Pamoate Salt 90
Milbemycin Oxime + Praziquantel 62
Pyrantel Pamoate;Sarolaner 58
Spinosad 13
Ivermectin 11
Fluralaner 13.64% 12-Week Chew 11
Milbemycin Oxime 10
Afoxolaner 9
Milbemycin Oxime, Lufenuron 8
Melarsomine Dihydrochloride 8
Oclacitinib Maleate 7
Ivermectin + Pyrantel 6
Carprofen 5
Outcome Breakdown
Ongoing
193 (39.2%)
Outcome Unknown
162 (32.9%)
Recovered/Normal
81 (16.5%)
Recovered with Sequela
49 (10.0%)
Died
5 (1.0%)
Euthanized
2 (0.4%)
Gender Distribution
Female 250 (51.1%)
Male 233 (47.6%)
Unknown 5 (1.0%)
Mixed 1 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2011 | 2 | |
| 2012 | 5 | |
| 2013 | 24 | |
| 2014 | 28 | |
| 2015 | 30 | |
| 2016 | 31 | |
| 2017 | 22 | |
| 2018 | 32 | |
| 2019 | 47 | |
| 2020 | 49 | |
| 2021 | 35 | |
| 2022 | 53 | |
| 2023 | 53 | |
| 2024 | 53 | |
| 2025 | 25 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #139 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.