Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
187
Total Reports
6
Deaths Reported
320.0%
Death Rate
4.3 yr
Avg Age at Report
Average weight at time of report: 42.1 kg (92.8 lbs)
Top Reported Reactions
Vomiting 31
Diarrhoea 19
Seizure NOS 15
Lethargy (see also Central nervous system depression in 'Neurological') 15
Lack of efficacy (endoparasite) - hookworm 13
Emesis 10
Lack of efficacy - NOS 9
Polyuria 9
Digestive tract disorder NOS 8
Polydipsia 8
Urinary incontinence 8
Lethargy (see also Central nervous system depression in Neurological) 8
INEFFECTIVE, ASCARIDS NOS 7
Lack of efficacy (ectoparasite) - flea 7
Lack of efficacy (endoparasite) - roundworm NOS 7
Most Referenced Drugs
Milbemycin Oxime + Spinosad 24
Pyrantel Pamoate;Sarolaner 23
Milbemycin Oxime + Praziquantel 21
Moxidectin 14
Carprofen 12
Oclacitinib Maleate 12
Lufenuron + Milbemycin Oxime 11
Bedinvetmab 10
Phenylpropanolamine Hydrochloride 9
Spinosad 8
Ivermectin + Pyrantel As Pamoate Salt 8
Fluralaner 13.64% 12-Week Chew 6
Afoxolaner 5
Lotilaner 5
Selamectin 4
Outcome Breakdown
Ongoing
58 (34.1%)
Recovered/Normal
57 (33.5%)
Outcome Unknown
46 (27.1%)
Recovered with Sequela
3 (1.8%)
Euthanized
3 (1.8%)
Died
3 (1.8%)
Gender Distribution
Male 104 (55.6%)
Female 82 (43.9%)
Unknown 1 (0.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 8 | |
| 2011 | 12 | |
| 2012 | 6 | |
| 2013 | 8 | |
| 2014 | 11 | |
| 2015 | 9 | |
| 2016 | 11 | |
| 2017 | 10 | |
| 2018 | 8 | |
| 2019 | 10 | |
| 2020 | 14 | |
| 2021 | 23 | |
| 2022 | 12 | |
| 2023 | 14 | |
| 2024 | 19 | |
| 2025 | 12 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #186 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.