Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
6,966
Total Reports
267
Deaths Reported
380.0%
Death Rate
7.1 yr
Avg Age at Report
Average weight at time of report: 7.3 kg (16.1 lbs)
Top Reported Reactions
Vomiting 1,793
Emesis 867
Lethargy (see also Central nervous system depression in 'Neurological') 785
Diarrhoea 617
Lack of efficacy (ectoparasite) - flea 452
Lack of efficacy - NOS 330
Anorexia 299
Lack of efficacy (endoparasite) - hookworm 262
Seizure NOS 202
Pruritus 199
Digestive tract disorder NOS 197
Behavioural disorder NOS 183
Other abnormal test result NOS 182
Emesis (multiple) 175
Decreased appetite 166
Most Referenced Drugs
Milbemycin Oxime + Spinosad 1,356
Spinosad 586
Ivermectin + Pyrantel As Pamoate Salt 493
Afoxolaner 477
Oclacitinib Maleate 418
Trilostane 370
Fluralaner Chew Tablets 299
Pyrantel Pamoate;Sarolaner 279
Moxidectin 211
Fluralaner 13.64% 12-Week Chew 171
Carprofen 167
Selamectin 152
Sarolaner 151
Milbemycin Oxime + Praziquantel 147
Maropitant Citrate 134
Outcome Breakdown
Recovered/Normal
2,688 (42.2%)
Outcome Unknown
1,821 (28.6%)
Ongoing
1,416 (22.3%)
Recovered with Sequela
172 (2.7%)
Euthanized
150 (2.4%)
Died
117 (1.8%)
Gender Distribution
Male 3,608 (51.8%)
Female 3,225 (46.3%)
Unknown 124 (1.8%)
Mixed 9 (0.1%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 303 | |
| 2011 | 439 | |
| 2012 | 631 | |
| 2013 | 624 | |
| 2014 | 670 | |
| 2015 | 588 | |
| 2016 | 551 | |
| 2017 | 547 | |
| 2018 | 449 | |
| 2019 | 404 | |
| 2020 | 374 | |
| 2021 | 285 | |
| 2022 | 305 | |
| 2023 | 285 | |
| 2024 | 327 | |
| 2025 | 184 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #32 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.