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Breed profile · FDA CVM July 2026 extract

Shepherd (unspecified) adverse-event record

Adverse-event filings for Shepherd (unspecified) (Dog) in the FDA Center for Veterinary Medicine openFDA extract. Browse dog breeds, reactions, and outcomes below.

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#67 of 510
by report volume (all breeds)
2,865
FDA CVM reports on file
4.4%
death-coded share of reports
#159 of 275
by death-coded share (≥50 reports)

How the 2,865 reports break down

By recorded gender -- every report on file for Shepherd (unspecified), no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 346 259.5 173 86.5 0 2019 2020 2021 2022 2023 2024 2025 2026 Reports filed Death-coded reports
Annual report volume for Shepherd (unspecified) drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Shepherd (unspecified) ranks #66 of 510 by total reports (2,865) and #159 of 275 by death-coded share (4.4%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#66
This breed, reports of 510
#159
This breed, death share of 275

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Shepherd (unspecified) has 2,865 reports now versus 2,808 in that prior snapshot: 57 more (2.0%).

Report change
+57
Death-coded reports
+4
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Shepherd (unspecified) changes

Total Reports

2,865

High report volume

Deaths Reported

126

of 2,865 reports

Death-coded share of reports

4.4%

Below-median death-coded share

Avg Age at Report

5.6 yr

27.5 kg avg weight

Breed Safety Scorecard

D (48/100)

A weighted composite across 4 of 4 dimensions, each benchmarked against every tracked breed with at least 200 reports (n=185). Dimensions with insufficient data drop out and their weight redistributes to the rest, so a missing input never silently deflates the score.

Death rate C-
4.4%

Share of reports coded as a fatality

Euthanasia rate D
2.3%

Share of reports resulting in euthanasia

Full recovery rate D
28.6%

Share of reports coded "Recovered/Normal"

5-year trend F
+20%

Change in annual report volume over the last 5 complete years

Death-Coded Outcome Share

Shepherd (unspecified) death-coded reports 4.4%
Cross-breed median

4.4% of 2,865 shepherd (unspecified) reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Where Shepherd (unspecified)'s death-coded share sits among indexed breeds

Death-coded share of FDA CVM reports, breeds with ≥50 reports (July 2026 extract)

4% 42nd percentile Higher share than 42% of 275 indexed breeds

5%–10%: 1 indexed breeds (0%). This entry sits in this band. 20%–25%: 2 indexed breeds (1%). Above this entry. 25%–30%: 3 indexed breeds (1%). Above this entry. 30%–35%: 4 indexed breeds (1%). Above this entry. 35%–40%: 5 indexed breeds (2%). Above this entry. 40%–45%: 6 indexed breeds (2%). Above this entry. 45%–50%: 3 indexed breeds (1%). Above this entry. 50%–55%: 7 indexed breeds (3%). Above this entry. 55%–60%: 7 indexed breeds (3%). Above this entry. 60%–65%: 21 indexed breeds (8%). Above this entry. 65%–70%: 11 indexed breeds (4%). Above this entry. 70%–75%: 15 indexed breeds (5%). Above this entry. 75%–80%: 13 indexed breeds (5%). Above this entry. 80%–85%: 11 indexed breeds (4%). Above this entry. 85%–90%: 12 indexed breeds (4%). Above this entry. 90%–95%: 12 indexed breeds (4%). Above this entry. 95%–100%: 142 indexed breeds (52%). Above this entry. Shepherd (unspecified) 5% 100% every breed with ≥50 FDA reports, bucketed by value

Each bar is a band; taller bars hold more indexed breeds. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.

Source FDA Center for Veterinary Medicine, openFDA adverse event extract (PlainBreed) · July 2026 extract

This histogram uses the same ≥50-report cohort as the highest death-coded share ranking. A higher share means more of this breed's reported events were death-coded, not a mortality rate for living animals.

Average weight at time of report: 27.5 kg (60.6 lbs)

Top Reported Reactions

Vomiting 517
Lack of efficacy (endoparasite) - heartworm 282
Lethargy (see also Central nervous system depression in 'Neurological') 227
Emesis 223
Diarrhoea 209
Lack of efficacy - NOS 134
Seizure NOS 127
Lack of efficacy (endoparasite) - hookworm 118
Lack of efficacy (ectoparasite) - flea 90
Lack of efficacy (bacteria) - Borrelia 90
INEFFECTIVE, HEARTWORM LARVAE 87
Ataxia 73
Decreased appetite 70
Anorexia 66
Behavioural disorder NOS 66

Most Referenced Drugs

Milbemycin Oxime + Spinosad 609
Pyrantel Pamoate;Sarolaner 482
Moxidectin 316
Milbemycin Oxime + Praziquantel 256
Bedinvetmab 240
Carprofen 162
Oclacitinib Maleate 152
Spinosad 142
Sarolaner 130
Selamectin 93
Gabapentin 85
Melarsomine Dihydrochloride 80
Grapiprant 78
Lotilaner 67
Prednisone 60

Outcome Breakdown

Ongoing
1,239 (43.2%)
Recovered/Normal
819 (28.6%)
Outcome Unknown
622 (21.7%)
Euthanized
66 (2.3%)
Died
60 (2.1%)
Recovered with Sequela
59 (2.1%)

Gender Distribution

Female 1,504 (52.5%)
Male 1,297 (45.3%)
Unknown 56 (2.0%)
Mixed 8 (0.3%)

Reports by Year

Year Reports Trend
2010 1
2011 16
2012 143
2013 208
2014 148
2015 159
2016 165
2017 189
2018 165
2019 187
2020 204
2021 204
2022 195
2023 247
2024 346
2025 244
2026 44

Shepherd (unspecified): high-volume FDA adverse-event cohort

Signature read: 2,865 reports place Shepherd (unspecified) in the upper third of breed filing volume (#67 of 510). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Shepherd (unspecified) sits at #67 of 510 by report volume among all breeds and #58 of 298 among dog breeds, with 2,865 reports and 126 (4.4%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #159 of 275. Mean age at report: 5.6 years, average weight 27.5 kg (60.6 lbs).

Top reported signs: Vomiting (517), Lack of efficacy (endoparasite) - heartworm (282), Lethargy (see also Central nervous system depression in 'Neurological') (227). Most-referenced drug: Milbemycin Oxime + Spinosad (609 reports), followed by Pyrantel Pamoate;Sarolaner (482) and Moxidectin (316).

Outcome coding on 2,865 status-recorded reports is dominated by Ongoing (43.2%). Annual submissions ranged 1-2,026 across 17 years on file.

Dog Breeds With a Similar Report Volume

Showing 6 of 297 dog breeds in our dataset, ranked by closest report volume.

Corgi (unspecified)
2,865 reports · 4.2% death-coded
Mastiff
2,950 reports · 6.2% death-coded
Terrier - Bull - Staffordshire
2,752 reports · 4.4% death-coded
Mountain Dog - Bernese
3,012 reports · 4.2% death-coded
Terrier - Rat
3,078 reports · 4.3% death-coded
Collie (unspecified)
3,131 reports · 4.8% death-coded

Nationwide breeds with similar profiles

High-volume peer sets for Shepherd (unspecified) drawn from openFDA outside the Dog family so the neighborhoods are not species containment (the similar-volume list above stays within species).

Similar death-coded share

Nearest other-species breeds with ≥50 reports (4.4% death-coded here).

Siberian 4.2% · Cat Bengal 4.6% · Cat Scottish Fold Longhair 4.8% · Cat British cat 3.8% · Cat

Similar average weight

Nearest other-species breeds by reported average weight (27.5 kg here).

Mixed (Sheep) 24.9 kg · Sheep Fish (other) 32.4 kg · Fish Katahdin 32.4 kg · Sheep Nubian 32.8 kg · Goat

What to do with this dog

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve Shepherd (unspecified)? ▼
There are 2,865 adverse event reports involving Shepherd (unspecified) in the FDA database, of which 126 were death-coded (4.4% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Shepherd (unspecified) ranks #67 of 510 by report volume among all breeds PlainBreed indexes (#58 of 298 among dog breeds).
Where does Shepherd (unspecified) sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Shepherd (unspecified) is #67 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Dog, it is #58 of 298. Among breeds with at least 50 reports, its death-coded share ranks #159 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Shepherd (unspecified)? ▼
The most commonly reported adverse reactions for Shepherd (unspecified) are Vomiting (517 reports), Lack of efficacy (endoparasite) - heartworm (282 reports), Lethargy (see also Central nervous system depression in 'Neurological') (227 reports), Emesis (223 reports), Diarrhoea (209 reports).
What drugs are most frequently associated with Shepherd (unspecified) adverse events? ▼
The drugs most frequently referenced in Shepherd (unspecified) adverse event reports are Milbemycin Oxime + Spinosad (609 reports), Pyrantel Pamoate;Sarolaner (482 reports), Moxidectin (316 reports), Milbemycin Oxime + Praziquantel (256 reports), Bedinvetmab (240 reports).
What is the average age of Shepherd (unspecified) in adverse event reports? ▼
The average age of Shepherd (unspecified) at the time of adverse event reports is 5.6 years, with an average weight of 27.5 kg (60.6 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Shepherd (unspecified) (Dog), extract as of July 2026 extract. 2,865 reports · 126 death-coded (4.4% of reports, not a mortality rate) · #67 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →