Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
2,725
Total Reports
119
Deaths Reported
440.0%
Death Rate
5.5 yr
Avg Age at Report
Average weight at time of report: 27.4 kg (60.4 lbs)
Top Reported Reactions
Vomiting 505
Lack of efficacy (endoparasite) - heartworm 261
Lethargy (see also Central nervous system depression in 'Neurological') 227
Emesis 222
Diarrhoea 198
Lack of efficacy - NOS 131
Seizure NOS 120
Lack of efficacy (endoparasite) - hookworm 109
INEFFECTIVE, HEARTWORM LARVAE 87
Lack of efficacy (ectoparasite) - flea 86
Lack of efficacy (bacteria) - Borrelia 79
Ataxia 69
Decreased appetite 68
Anorexia 64
Behavioural disorder NOS 64
Most Referenced Drugs
Milbemycin Oxime + Spinosad 609
Pyrantel Pamoate;Sarolaner 428
Moxidectin 306
Milbemycin Oxime + Praziquantel 250
Bedinvetmab 201
Carprofen 151
Oclacitinib Maleate 144
Spinosad 142
Sarolaner 126
Selamectin 93
Melarsomine Dihydrochloride 76
Gabapentin 75
Grapiprant 71
Lotilaner 63
Prednisone 59
Outcome Breakdown
Ongoing
1,134 (41.6%)
Recovered/Normal
801 (29.4%)
Outcome Unknown
612 (22.5%)
Euthanized
65 (2.4%)
Recovered with Sequela
59 (2.2%)
Died
54 (2.0%)
Gender Distribution
Female 1,427 (52.4%)
Male 1,237 (45.4%)
Unknown 53 (1.9%)
Mixed 8 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 1 | |
| 2011 | 16 | |
| 2012 | 143 | |
| 2013 | 208 | |
| 2014 | 148 | |
| 2015 | 159 | |
| 2016 | 165 | |
| 2017 | 189 | |
| 2018 | 165 | |
| 2019 | 187 | |
| 2020 | 204 | |
| 2021 | 204 | |
| 2022 | 194 | |
| 2023 | 244 | |
| 2024 | 339 | |
| 2025 | 159 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #67 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.