Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
2,409
Total Reports
119
Deaths Reported
490.0%
Death Rate
4.3 yr
Avg Age at Report
Average weight at time of report: 31.7 kg (69.9 lbs)
Top Reported Reactions
Vomiting 516
Emesis 214
Lack of efficacy (endoparasite) - heartworm 203
Lethargy (see also Central nervous system depression in 'Neurological') 195
Diarrhoea 180
Lack of efficacy (ectoparasite) - flea 161
Lack of efficacy - NOS 131
INEFFECTIVE, HEARTWORM LARVAE 106
Hives (see also 'Skin') 103
Lack of efficacy (endoparasite) - hookworm 81
Seizure NOS 77
Anorexia 61
Death by euthanasia 58
Facial swelling (see also 'Skin') 57
Emesis (multiple) 57
Most Referenced Drugs
Milbemycin Oxime + Spinosad 595
Moxidectin 218
Oclacitinib Maleate 195
Pyrantel Pamoate;Sarolaner 168
Spinosad 145
Milbemycin Oxime + Praziquantel 133
Fluralaner Chew Tablets 115
Fluralaner 13.64% 12-Week Chew 111
Carprofen 91
Ivermectin + Pyrantel As Pamoate Salt 69
Bedinvetmab 69
Sarolaner 55
Trilostane 50
Maropitant Citrate 45
Selamectin 43
Outcome Breakdown
Recovered/Normal
761 (33.0%)
Ongoing
755 (32.8%)
Outcome Unknown
614 (26.6%)
Died
65 (2.8%)
Recovered with Sequela
56 (2.4%)
Euthanized
54 (2.3%)
Gender Distribution
Male 1,370 (56.9%)
Female 989 (41.1%)
Unknown 41 (1.7%)
Mixed 9 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 54 | |
| 2011 | 60 | |
| 2012 | 99 | |
| 2013 | 131 | |
| 2014 | 147 | |
| 2015 | 181 | |
| 2016 | 160 | |
| 2017 | 196 | |
| 2018 | 190 | |
| 2019 | 176 | |
| 2020 | 207 | |
| 2021 | 169 | |
| 2022 | 172 | |
| 2023 | 157 | |
| 2024 | 192 | |
| 2025 | 118 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #73 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.