Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
998
Total Reports
43
Deaths Reported
430.0%
Death Rate
5.1 yr
Avg Age at Report
Average weight at time of report: 24.0 kg (52.9 lbs)
Top Reported Reactions
Vomiting 180
Diarrhoea 86
Lack of efficacy (endoparasite) - heartworm 85
Lethargy (see also Central nervous system depression in 'Neurological') 79
Lack of efficacy - NOS 63
INEFFECTIVE, HEARTWORM LARVAE 59
Emesis 55
Lack of efficacy (ectoparasite) - flea 47
Anorexia 41
Lack of efficacy (endoparasite) - hookworm 38
Ataxia 33
Other abnormal test result NOS 32
Behavioural disorder NOS 32
Panting 31
Not eating 29
Most Referenced Drugs
Milbemycin Oxime + Spinosad 143
Oclacitinib Maleate 111
Ivermectin + Pyrantel As Pamoate Salt 101
Bedinvetmab 65
Moxidectin 57
Afoxolaner 52
Pyrantel Pamoate;Sarolaner 49
Spinosad 48
Milbemycin Oxime + Praziquantel 37
Gabapentin 36
Carprofen 34
Fluralaner Chew Tablets 30
Prednisone 22
Grapiprant 22
Galliprant 22
Outcome Breakdown
Ongoing
302 (33.0%)
Outcome Unknown
279 (30.5%)
Recovered/Normal
245 (26.7%)
Recovered with Sequela
47 (5.1%)
Died
23 (2.5%)
Euthanized
20 (2.2%)
Gender Distribution
Female 500 (50.1%)
Male 482 (48.3%)
Unknown 14 (1.4%)
Mixed 2 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 38 | |
| 2011 | 58 | |
| 2012 | 53 | |
| 2013 | 57 | |
| 2014 | 75 | |
| 2015 | 73 | |
| 2016 | 71 | |
| 2017 | 81 | |
| 2018 | 61 | |
| 2019 | 58 | |
| 2020 | 46 | |
| 2021 | 48 | |
| 2022 | 50 | |
| 2023 | 73 | |
| 2024 | 107 | |
| 2025 | 49 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #110 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.