Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
5,279
Total Reports
215
Deaths Reported
410.0%
Death Rate
6.2 yr
Avg Age at Report
Average weight at time of report: 9.6 kg (21.2 lbs)
Top Reported Reactions
Vomiting 1,229
Emesis 617
Lethargy (see also Central nervous system depression in 'Neurological') 481
Diarrhoea 397
Lack of efficacy (ectoparasite) - flea 331
Lack of efficacy (endoparasite) - hookworm 328
Anorexia 245
Lack of efficacy - NOS 228
Depression 208
Seizure NOS 197
INEFFECTIVE, HEARTWORM LARVAE 163
Elevated serum alkaline phosphatase (SAP) 155
Elevated alanine aminotransferase (ALT) 134
Pruritus 129
Behavioural disorder NOS 128
Most Referenced Drugs
Milbemycin Oxime + Spinosad 1,210
Spinosad 645
Ivermectin + Pyrantel As Pamoate Salt 337
Moxidectin 252
Afoxolaner 237
Pyrantel Pamoate;Sarolaner 221
Trilostane 169
Oclacitinib Maleate 154
Ivermectin, Pyrantel 150
Fluralaner Chew Tablets 146
Carprofen 115
Milbemycin Oxime + Praziquantel 102
Selamectin 101
Sarolaner 100
Milbemycin 85
Outcome Breakdown
Recovered/Normal
1,684 (39.6%)
Outcome Unknown
1,284 (30.2%)
Ongoing
895 (21.0%)
Recovered with Sequela
177 (4.2%)
Died
131 (3.1%)
Euthanized
84 (2.0%)
Gender Distribution
Male 2,600 (49.3%)
Female 2,546 (48.2%)
Unknown 111 (2.1%)
Mixed 22 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 521 | |
| 2011 | 621 | |
| 2012 | 566 | |
| 2013 | 429 | |
| 2014 | 380 | |
| 2015 | 354 | |
| 2016 | 369 | |
| 2017 | 312 | |
| 2018 | 294 | |
| 2019 | 276 | |
| 2020 | 240 | |
| 2021 | 220 | |
| 2022 | 185 | |
| 2023 | 182 | |
| 2024 | 204 | |
| 2025 | 126 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #39 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.