Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
17,507
Total Reports
635
Deaths Reported
360.0%
Death Rate
5.7 yr
Avg Age at Report
Average weight at time of report: 14.6 kg (32.2 lbs)
Top Reported Reactions
Vomiting 2,869
Lack of efficacy (endoparasite) - hookworm 1,654
Lack of efficacy (endoparasite) - heartworm 1,577
INEFFECTIVE, HEARTWORM LARVAE 1,280
Lethargy (see also Central nervous system depression in 'Neurological') 1,222
Emesis 1,161
Lack of efficacy - NOS 1,128
Digestive tract disorder NOS 1,016
Diarrhoea 1,000
Lack of efficacy (ectoparasite) - flea 644
Seizure NOS 634
INEFFECTIVE, HOOKS 589
INEFFECTIVE, ASCARIDS NOS 512
Anorexia 473
Other abnormal test result NOS 414
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 2,805
Milbemycin Oxime + Spinosad 2,591
Afoxolaner 1,033
Moxidectin 1,022
Milbemycin Oxime + Praziquantel 943
Pyrantel Pamoate;Sarolaner 933
Spinosad 737
Trilostane 681
Oclacitinib Maleate 544
Fluralaner Chew Tablets 538
Carprofen 418
Melarsomine Dihydrochloride 410
Sarolaner 387
Fluralaner 13.64% 12-Week Chew 334
Milbemycin Oxime 294
Outcome Breakdown
Outcome Unknown
6,223 (37.9%)
Recovered/Normal
4,617 (28.1%)
Ongoing
4,067 (24.8%)
Recovered with Sequela
879 (5.4%)
Euthanized
351 (2.1%)
Died
289 (1.8%)
Gender Distribution
Female 9,015 (51.5%)
Male 8,154 (46.6%)
Unknown 250 (1.4%)
Mixed 88 (0.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 609 | |
| 2011 | 716 | |
| 2012 | 1,156 | |
| 2013 | 1,119 | |
| 2014 | 1,180 | |
| 2015 | 1,270 | |
| 2016 | 1,354 | |
| 2017 | 1,399 | |
| 2018 | 1,314 | |
| 2019 | 1,272 | |
| 2020 | 1,207 | |
| 2021 | 1,107 | |
| 2022 | 977 | |
| 2023 | 1,108 | |
| 2024 | 1,105 | |
| 2025 | 614 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #11 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.