Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,243
Total Reports
31
Deaths Reported
250.0%
Death Rate
5.9 yr
Avg Age at Report
Average weight at time of report: 12.7 kg (28.0 lbs)
Top Reported Reactions
Vomiting 245
Emesis 127
Lack of efficacy (ectoparasite) - flea 115
Diarrhoea 107
Lack of efficacy (endoparasite) - hookworm 103
Lethargy (see also Central nervous system depression in 'Neurological') 78
Lack of efficacy - NOS 59
Lack of efficacy (endoparasite) - heartworm 51
Lack of efficacy (ectoparasite) - tick NOS 46
Seizure NOS 44
Emesis (multiple) 35
Lack of efficacy (endoparasite) - roundworm NOS 32
Lack of efficacy (bacteria) - NOS 30
Lack of efficacy (bacteria) - Borrelia 28
Itching 26
Most Referenced Drugs
Milbemycin Oxime + Spinosad 291
Fluralaner Chew Tablets 147
Ivermectin + Pyrantel As Pamoate Salt 142
Afoxolaner 105
Spinosad 81
Fluralaner 13.64% 12-Week Chew 60
Milbemycin Oxime + Praziquantel 57
Pyrantel Pamoate;Sarolaner 42
Moxidectin 28
Oclacitinib Maleate 25
Lotilaner 22
Trilostane 19
Ivermectin + Pyrantel 19
Pimobendan 16
Nitenpyram 15
Outcome Breakdown
Recovered/Normal
458 (36.8%)
Outcome Unknown
400 (32.2%)
Ongoing
310 (24.9%)
Recovered with Sequela
45 (3.6%)
Euthanized
22 (1.8%)
Died
9 (0.7%)
Gender Distribution
Male 642 (51.6%)
Female 582 (46.8%)
Unknown 14 (1.1%)
Mixed 5 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 1 | |
| 2011 | 14 | |
| 2012 | 117 | |
| 2013 | 116 | |
| 2014 | 60 | |
| 2015 | 111 | |
| 2016 | 94 | |
| 2017 | 73 | |
| 2018 | 82 | |
| 2019 | 90 | |
| 2020 | 63 | |
| 2021 | 94 | |
| 2022 | 72 | |
| 2023 | 95 | |
| 2024 | 86 | |
| 2025 | 75 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #99 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.