Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
197
Total Reports
4
Deaths Reported
200.0%
Death Rate
5.0 yr
Avg Age at Report
Average weight at time of report: 27.0 kg (59.5 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 52
Vomiting 27
Lack of efficacy (ectoparasite) - flea 18
Diarrhoea 14
Not eating 12
Lack of efficacy (endoparasite) - hookworm 10
Lethargy (see also Central nervous system depression in Neurological) 10
Lethargy (see also Central nervous system depression in 'Neurological') 9
Emesis (multiple) 9
Overdose 8
Drug dose omission 7
Behavioural disorder NOS 7
INEFFECTIVE, HOOKS 6
Lack of efficacy - NOS 6
Other abnormal test result NOS 6
Most Referenced Drugs
Milbemycin Oxime + Spinosad 54
Milbemycin Oxime + Praziquantel 45
Ivermectin + Pyrantel As Pamoate Salt 21
Lotilaner 17
Fluralaner 13.64% 12-Week Chew 14
Gabapentin 11
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 10
Oclacitinib Maleate 9
Ilunocitinib 8
Clotrimazole + Gentamicin + Mometasone 7
Milbemycin Oxime 6
Nitenpyram 5
Afoxolaner 5
Ivermectin + Pyrantel 5
Ivermectin 4
Outcome Breakdown
Outcome Unknown
100 (50.8%)
Ongoing
54 (27.4%)
Recovered/Normal
36 (18.3%)
Recovered with Sequela
3 (1.5%)
Euthanized
2 (1.0%)
Died
2 (1.0%)
Gender Distribution
Female 103 (52.3%)
Male 92 (46.7%)
Unknown 2 (1.0%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2016 | 1 | |
| 2017 | 1 | |
| 2018 | 14 | |
| 2019 | 10 | |
| 2020 | 26 | |
| 2021 | 15 | |
| 2022 | 36 | |
| 2023 | 33 | |
| 2024 | 35 | |
| 2025 | 26 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #184 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.