Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
40
Total Reports
2
Deaths Reported
500.0%
Death Rate
8.4 yr
Avg Age at Report
Average weight at time of report: 20.0 kg (44.1 lbs)
Top Reported Reactions
Diarrhoea 8
Vomiting 7
Seizure NOS 5
Lethargy (see also Central nervous system depression in 'Neurological') 4
Shaking 3
Pancreatitis 3
INEFFECTIVE, GLYCEMIC CONTROL 3
Itching 2
Death 2
Emesis 2
Anorexia 2
Hypoglycaemia 2
Decreased appetite 2
Anxiety 2
INEFFECTIVE, ATOPY CONTROL 2
Most Referenced Drugs
Milbemycin Oxime + Spinosad 9
Insulin Injectable Vial 5
Cyclosporine 4
Oclacitinib Maleate 4
Milbemycin Oxime, Lufenuron 3
Afoxolaner 3
Grapiprant 3
Ivermectin + Pyrantel As Pamoate Salt 2
Fluralaner Chew Tablets 2
Milbemycin Oxime + Praziquantel 2
Fipronil 2
Moxidectin 2
Betamethasone Valerate, Usp + Clotrimazole, Usp + Gentamicin Sulfate, Usp 1
Spinosad 1
Milbemycin Oxime + Lufenuron 1
Outcome Breakdown
Recovered/Normal
13 (34.2%)
Outcome Unknown
10 (26.3%)
Ongoing
10 (26.3%)
Recovered with Sequela
3 (7.9%)
Died
2 (5.3%)
Gender Distribution
Male 24 (60.0%)
Female 16 (40.0%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2011 | 3 | |
| 2012 | 2 | |
| 2013 | 4 | |
| 2014 | 4 | |
| 2015 | 5 | |
| 2016 | 1 | |
| 2017 | 6 | |
| 2018 | 4 | |
| 2019 | 2 | |
| 2021 | 4 | |
| 2023 | 2 | |
| 2025 | 3 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #289 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.