Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
126
Total Reports
11
Deaths Reported
870.0%
Death Rate
5.8 yr
Avg Age at Report
Average weight at time of report: 27.0 kg (59.5 lbs)
Top Reported Reactions
Vomiting 24
Emesis 24
Lethargy (see also Central nervous system depression in 'Neurological') 19
Diarrhoea 14
Lack of efficacy (ectoparasite) - flea 10
Death 9
Behavioural disorder NOS 5
Digestive tract disorder NOS 4
INEFFECTIVE, ASCARIDS NOS 4
Panting 4
Decreased appetite 4
Lack of efficacy (endoparasite) - hookworm 4
Other abnormal test result NOS 4
Itching 4
Elevated alanine aminotransferase (ALT) 3
Most Referenced Drugs
Spinosad 26
Milbemycin Oxime + Spinosad 24
Afoxolaner 9
Fluralaner Chew Tablets 6
Ivermectin + Pyrantel As Pamoate Salt 6
Ivermectin, Pyrantel 5
Ivermectin + Pyrantel 4
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 3
Nitenpyram 3
Pyrantel Pamoate;Sarolaner 3
Selamectin 2
Enrofloxacin 2
Fluoxetine Hydrochloride 2
Firocoxib 2
Imidacloprid + Moxidectin 2
Outcome Breakdown
Recovered/Normal
57 (47.5%)
Outcome Unknown
30 (25.0%)
Ongoing
19 (15.8%)
Died
9 (7.5%)
Recovered with Sequela
3 (2.5%)
Euthanized
2 (1.7%)
Gender Distribution
Female 56 (44.4%)
Male 56 (44.4%)
Unknown 13 (10.3%)
Mixed 1 (0.8%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 2 | |
| 2011 | 10 | |
| 2012 | 25 | |
| 2013 | 12 | |
| 2014 | 18 | |
| 2015 | 15 | |
| 2016 | 9 | |
| 2017 | 5 | |
| 2018 | 5 | |
| 2019 | 4 | |
| 2020 | 5 | |
| 2021 | 4 | |
| 2022 | 3 | |
| 2023 | 3 | |
| 2024 | 3 | |
| 2025 | 3 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #218 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.