Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
4,495
Total Reports
256
Deaths Reported
570.0%
Death Rate
4.5 yr
Avg Age at Report
Average weight at time of report: 33.8 kg (74.5 lbs)
Top Reported Reactions
Vomiting 705
Lack of efficacy (endoparasite) - heartworm 465
Diarrhoea 357
Emesis 346
INEFFECTIVE, HEARTWORM LARVAE 333
Lethargy (see also Central nervous system depression in 'Neurological') 320
Lack of efficacy (endoparasite) - hookworm 314
Lack of efficacy - NOS 301
Digestive tract disorder NOS 163
Anorexia 149
Death 137
Lack of efficacy (ectoparasite) - flea 129
Other abnormal test result NOS 127
Cardiac disorder NOS 112
Seizure NOS 109
Most Referenced Drugs
Milbemycin Oxime + Spinosad 846
Ivermectin + Pyrantel As Pamoate Salt 609
Afoxolaner 261
Moxidectin 249
Pyrantel Pamoate;Sarolaner 226
Milbemycin Oxime + Praziquantel 220
Spinosad 193
Carprofen 141
Fluralaner Chew Tablets 139
Oclacitinib Maleate 101
Fluralaner 13.64% 12-Week Chew 96
Bedinvetmab 92
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 84
Ivermectin, Pyrantel 80
Selamectin 75
Outcome Breakdown
Outcome Unknown
1,414 (34.1%)
Recovered/Normal
1,184 (28.5%)
Ongoing
1,082 (26.1%)
Recovered with Sequela
213 (5.1%)
Died
164 (3.9%)
Euthanized
95 (2.3%)
Gender Distribution
Female 2,214 (49.3%)
Male 2,175 (48.4%)
Unknown 89 (2.0%)
Mixed 17 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 193 | |
| 2011 | 213 | |
| 2012 | 300 | |
| 2013 | 337 | |
| 2014 | 315 | |
| 2015 | 328 | |
| 2016 | 344 | |
| 2017 | 335 | |
| 2018 | 282 | |
| 2019 | 272 | |
| 2020 | 276 | |
| 2021 | 255 | |
| 2022 | 277 | |
| 2023 | 279 | |
| 2024 | 310 | |
| 2025 | 179 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #43 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.