Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
8,232
Total Reports
374
Deaths Reported
450.0%
Death Rate
4.8 yr
Avg Age at Report
Average weight at time of report: 27.7 kg (61.1 lbs)
Top Reported Reactions
Vomiting 1,543
Lack of efficacy (endoparasite) - heartworm 1,016
Hives (see also 'Skin') 810
Lethargy (see also Central nervous system depression in 'Neurological') 678
Facial swelling (see also 'Skin') 600
Diarrhoea 588
Anaphylaxis 407
Lack of efficacy - NOS 369
Seizure NOS 343
Emesis 285
Lack of efficacy (endoparasite) - hookworm 282
Lethargy (see also Central nervous system depression in Neurological) 254
Anorexia 235
Ataxia 221
Erythema (for urticaria see Immune SOC) 207
Most Referenced Drugs
Moxidectin 2,705
Pyrantel Pamoate;Sarolaner 1,554
Oclacitinib Maleate 1,331
Bedinvetmab 758
Carprofen 484
Sarolaner 460
Melarsomine Dihydrochloride 434
Anti-Il31 Mab Mcs Lot #1283563 314
Maropitant Citrate 300
Gabapentin 278
Prednisone 273
Milbemycin Oxime + Spinosad 257
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 232
Selamectin 173
Diphenhydramine Hcl 158
Outcome Breakdown
Ongoing
5,054 (61.6%)
Recovered/Normal
1,817 (22.2%)
Outcome Unknown
921 (11.2%)
Euthanized
199 (2.4%)
Died
176 (2.1%)
Recovered with Sequela
32 (0.4%)
Gender Distribution
Female 4,152 (50.4%)
Male 3,923 (47.7%)
Unknown 115 (1.4%)
Mixed 42 (0.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 27 | |
| 2011 | 114 | |
| 2012 | 198 | |
| 2013 | 129 | |
| 2014 | 233 | |
| 2015 | 303 | |
| 2016 | 344 | |
| 2017 | 522 | |
| 2018 | 539 | |
| 2019 | 581 | |
| 2020 | 717 | |
| 2021 | 789 | |
| 2022 | 787 | |
| 2023 | 997 | |
| 2024 | 1,246 | |
| 2025 | 706 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #24 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.