Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
479
Total Reports
18
Deaths Reported
380.0%
Death Rate
6.7 yr
Avg Age at Report
Average weight at time of report: 6.1 kg (13.5 lbs)
Top Reported Reactions
Vomiting 129
Diarrhoea 46
Lethargy (see also Central nervous system depression in 'Neurological') 46
Emesis 33
Lack of efficacy (ectoparasite) - flea 29
Seizure NOS 24
Lack of efficacy - NOS 19
Ataxia 18
Lack of efficacy (endoparasite) - hookworm 17
Anorexia 17
Pruritus 15
Other abnormal test result NOS 14
Anaphylaxis 13
Elevated alanine aminotransferase (ALT) 13
Behavioural disorder NOS 12
Most Referenced Drugs
Milbemycin Oxime + Spinosad 66
Moxidectin 39
Spinosad 34
Ivermectin + Pyrantel As Pamoate Salt 34
Afoxolaner 31
Pimobendan 29
Milbemycin Oxime + Praziquantel 26
Oclacitinib Maleate 25
Pyrantel Pamoate;Sarolaner 18
Fluralaner Chew Tablets 15
Sarolaner 11
Fluralaner 13.64% 12-Week Chew 11
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 9
Anti-Il31 Mab Mcs Lot #1283563 9
Cyclosporine 8
Outcome Breakdown
Recovered/Normal
162 (37.7%)
Outcome Unknown
133 (30.9%)
Ongoing
107 (24.9%)
Died
11 (2.6%)
Recovered with Sequela
10 (2.3%)
Euthanized
7 (1.6%)
Gender Distribution
Male 240 (50.1%)
Female 223 (46.6%)
Unknown 13 (2.7%)
Mixed 3 (0.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 20 | |
| 2011 | 35 | |
| 2012 | 29 | |
| 2013 | 34 | |
| 2014 | 29 | |
| 2015 | 27 | |
| 2016 | 44 | |
| 2017 | 35 | |
| 2018 | 34 | |
| 2019 | 35 | |
| 2020 | 37 | |
| 2021 | 26 | |
| 2022 | 23 | |
| 2023 | 34 | |
| 2024 | 19 | |
| 2025 | 18 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #141 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.