Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
13,674
Total Reports
443
Deaths Reported
320.0%
Death Rate
5.6 yr
Avg Age at Report
Average weight at time of report: 4.8 kg (10.6 lbs)
Top Reported Reactions
Vomiting 3,343
Lethargy (see also Central nervous system depression in 'Neurological') 1,928
Emesis 1,548
Lack of efficacy (ectoparasite) - flea 1,413
Diarrhoea 1,208
Lack of efficacy - NOS 645
Anorexia 550
Seizure NOS 541
Behavioural disorder NOS 500
Shaking 454
Other abnormal test result NOS 385
Lack of efficacy (endoparasite) - hookworm 356
Not eating 353
Ataxia 347
Emesis (multiple) 344
Most Referenced Drugs
Milbemycin Oxime + Spinosad 3,251
Spinosad 1,375
Afoxolaner 940
Ivermectin + Pyrantel As Pamoate Salt 853
Trilostane 624
Fluralaner Chew Tablets 554
Moxidectin 553
Oclacitinib Maleate 484
Pyrantel Pamoate;Sarolaner 442
Fluralaner 13.64% 12-Week Chew 370
Milbemycin Oxime + Praziquantel 332
Selamectin 327
Sarolaner 321
Imidacloprid + Moxidectin 298
Nitenpyram 229
Outcome Breakdown
Recovered/Normal
5,337 (41.3%)
Outcome Unknown
4,097 (31.7%)
Ongoing
2,621 (20.3%)
Recovered with Sequela
422 (3.3%)
Died
251 (1.9%)
Euthanized
192 (1.5%)
Gender Distribution
Female 6,774 (49.5%)
Male 6,586 (48.2%)
Unknown 288 (2.1%)
Mixed 26 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 379 | |
| 2011 | 680 | |
| 2012 | 1,160 | |
| 2013 | 1,265 | |
| 2014 | 1,162 | |
| 2015 | 1,161 | |
| 2016 | 1,123 | |
| 2017 | 1,089 | |
| 2018 | 982 | |
| 2019 | 894 | |
| 2020 | 851 | |
| 2021 | 802 | |
| 2022 | 751 | |
| 2023 | 589 | |
| 2024 | 495 | |
| 2025 | 291 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #14 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.