Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
621
Total Reports
51
Deaths Reported
820.0%
Death Rate
8.8 yr
Avg Age at Report
Average weight at time of report: 8.3 kg (18.3 lbs)
Top Reported Reactions
Vomiting 126
Lethargy (see also Central nervous system depression in 'Neurological') 72
Diarrhoea 52
Elevated serum alkaline phosphatase (SAP) 46
Hyperkalaemia 37
Elevated blood urea nitrogen (BUN) 35
Underdose 34
Elevated alanine aminotransferase (ALT) 33
Emesis 32
INEFFECTIVE, CUSHINGS 32
Decreased appetite 26
Death by euthanasia 26
Weight loss 24
Death 23
Anorexia 23
Most Referenced Drugs
Trilostane 349
Milbemycin Oxime + Spinosad 81
Moxidectin 75
Pyrantel Pamoate;Sarolaner 29
Spinosad 28
Oclacitinib Maleate 26
Fluralaner Chew Tablets 21
Carprofen 19
Sarolaner 16
Maropitant Citrate 13
Insulin 11
Milbemycin Oxime + Praziquantel 10
Bedinvetmab 8
Cefpodoxime Proxetil 7
Ivermectin 7
Outcome Breakdown
Outcome Unknown
227 (36.6%)
Recovered/Normal
177 (28.5%)
Ongoing
158 (25.4%)
Euthanized
27 (4.3%)
Died
24 (3.9%)
Recovered with Sequela
8 (1.3%)
Gender Distribution
Female 312 (50.2%)
Male 300 (48.3%)
Unknown 8 (1.3%)
Mixed 1 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 1 | |
| 2011 | 5 | |
| 2012 | 38 | |
| 2013 | 24 | |
| 2014 | 20 | |
| 2015 | 33 | |
| 2016 | 51 | |
| 2017 | 73 | |
| 2018 | 62 | |
| 2019 | 67 | |
| 2020 | 55 | |
| 2021 | 45 | |
| 2022 | 45 | |
| 2023 | 43 | |
| 2024 | 37 | |
| 2025 | 22 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #127 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.