Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
24,408
Total Reports
904
Deaths Reported
370.0%
Death Rate
5.7 yr
Avg Age at Report
Average weight at time of report: 4.2 kg (9.3 lbs)
Top Reported Reactions
Vomiting 6,294
Lethargy (see also Central nervous system depression in 'Neurological') 2,984
Emesis 2,851
Lack of efficacy (ectoparasite) - flea 2,358
Diarrhoea 2,290
Seizure NOS 1,108
Lack of efficacy - NOS 1,065
Anorexia 981
Shaking 818
Behavioural disorder NOS 773
Ataxia 708
Not eating 680
Emesis (multiple) 679
Pruritus 651
Overdose 596
Most Referenced Drugs
Milbemycin Oxime + Spinosad 5,198
Spinosad 2,768
Afoxolaner 1,547
Ivermectin + Pyrantel As Pamoate Salt 1,317
Moxidectin 1,147
Fluralaner Chew Tablets 1,128
Pyrantel Pamoate;Sarolaner 1,090
Oclacitinib Maleate 892
Sarolaner 729
Fluralaner 13.64% 12-Week Chew 720
Selamectin 641
Imidacloprid + Moxidectin 568
Trilostane 539
Milbemycin Oxime + Praziquantel 533
Nitenpyram 471
Outcome Breakdown
Recovered/Normal
9,277 (40.9%)
Outcome Unknown
6,753 (29.8%)
Ongoing
4,992 (22.0%)
Recovered with Sequela
742 (3.3%)
Died
545 (2.4%)
Euthanized
359 (1.6%)
Gender Distribution
Female 12,047 (49.4%)
Male 11,678 (47.8%)
Unknown 605 (2.5%)
Mixed 78 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 885 | |
| 2011 | 1,411 | |
| 2012 | 2,131 | |
| 2013 | 2,107 | |
| 2014 | 2,020 | |
| 2015 | 2,013 | |
| 2016 | 1,903 | |
| 2017 | 1,982 | |
| 2018 | 1,609 | |
| 2019 | 1,496 | |
| 2020 | 1,438 | |
| 2021 | 1,234 | |
| 2022 | 1,111 | |
| 2023 | 1,096 | |
| 2024 | 1,218 | |
| 2025 | 754 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #8 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.