Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
277
Total Reports
20
Deaths Reported
720.0%
Death Rate
3.9 yr
Avg Age at Report
Average weight at time of report: 49.1 kg (108.3 lbs)
Top Reported Reactions
Vomiting 56
Diarrhoea 32
Emesis 28
Lethargy (see also Central nervous system depression in 'Neurological') 19
Lack of efficacy (endoparasite) - heartworm 15
Lack of efficacy (endoparasite) - hookworm 13
Lack of efficacy - NOS 12
Death by euthanasia 11
Lack of efficacy (ectoparasite) - flea 10
Digestive tract disorder NOS 10
Death 8
Lack of efficacy (endoparasite) - whipworm 8
Underdose 8
Weight loss 8
Abnormal radiograph finding 8
Most Referenced Drugs
Milbemycin Oxime + Spinosad 67
Ivermectin + Pyrantel As Pamoate Salt 34
Pyrantel Pamoate;Sarolaner 25
Afoxolaner 21
Moxidectin 20
Spinosad 18
Bedinvetmab 14
Fluralaner Chew Tablets 12
Milbemycin Oxime + Praziquantel 12
Oclacitinib Maleate 10
Carprofen 9
Fluralaner 13.64% 12-Week Chew 9
Grapiprant 7
Firocoxib 6
Lufenuron + Milbemycin Oxime 6
Outcome Breakdown
Recovered/Normal
89 (34.2%)
Ongoing
81 (31.2%)
Outcome Unknown
65 (25.0%)
Euthanized
11 (4.2%)
Died
9 (3.5%)
Recovered with Sequela
5 (1.9%)
Gender Distribution
Male 159 (57.4%)
Female 113 (40.8%)
Unknown 4 (1.4%)
Mixed 1 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 11 | |
| 2011 | 10 | |
| 2012 | 13 | |
| 2013 | 26 | |
| 2014 | 19 | |
| 2015 | 23 | |
| 2016 | 18 | |
| 2017 | 21 | |
| 2018 | 18 | |
| 2019 | 19 | |
| 2020 | 10 | |
| 2021 | 18 | |
| 2022 | 9 | |
| 2023 | 18 | |
| 2024 | 26 | |
| 2025 | 18 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #170 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.