Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
232
Total Reports
7
Deaths Reported
300.0%
Death Rate
6.1 yr
Avg Age at Report
Average weight at time of report: 7.1 kg (15.7 lbs)
Top Reported Reactions
Vomiting 43
Lethargy (see also Central nervous system depression in 'Neurological') 37
Diarrhoea 28
Shaking 12
Emesis 12
Behavioural disorder NOS 12
Seizure NOS 11
INEFFECTIVE, ASCARIDS NOS 10
Trembling 10
Lack of efficacy - NOS 9
Lack of efficacy (endoparasite) - hookworm 9
Panting 7
Digestive tract disorder NOS 7
Decreased appetite 7
Lack of efficacy (endoparasite) - heartworm 7
Most Referenced Drugs
Milbemycin Oxime + Spinosad 75
Ivermectin + Pyrantel As Pamoate Salt 21
Pyrantel Pamoate;Sarolaner 18
Trilostane 16
Spinosad 15
Afoxolaner 11
Fluralaner Chew Tablets 7
Oclacitinib Maleate 7
Ivermectin 5
Milbemycin Oxime + Praziquantel 5
Meloxicam 4
Milbemycin Oxime 4
Ivermectin + Pyrantel 4
Sarolaner 4
Grapiprant 4
Outcome Breakdown
Recovered/Normal
89 (41.4%)
Outcome Unknown
64 (29.8%)
Ongoing
45 (20.9%)
Recovered with Sequela
10 (4.7%)
Euthanized
5 (2.3%)
Died
2 (0.9%)
Gender Distribution
Female 114 (49.1%)
Male 111 (47.8%)
Unknown 6 (2.6%)
Mixed 1 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 8 | |
| 2011 | 12 | |
| 2012 | 28 | |
| 2013 | 18 | |
| 2014 | 16 | |
| 2015 | 23 | |
| 2016 | 22 | |
| 2017 | 13 | |
| 2018 | 23 | |
| 2019 | 6 | |
| 2020 | 14 | |
| 2021 | 13 | |
| 2022 | 6 | |
| 2023 | 12 | |
| 2024 | 13 | |
| 2025 | 5 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #176 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.