Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
227
Total Reports
12
Deaths Reported
530.0%
Death Rate
6.4 yr
Avg Age at Report
Average weight at time of report: 27.6 kg (60.9 lbs)
Top Reported Reactions
Vomiting 44
Lack of efficacy (endoparasite) - hookworm 22
Diarrhoea 20
Digestive tract disorder NOS 19
Lack of efficacy - NOS 19
Lethargy (see also Central nervous system depression in 'Neurological') 17
Anorexia 14
Emesis 14
Seizure NOS 12
Lack of efficacy (endoparasite) - whipworm 10
INEFFECTIVE, ASCARIDS NOS 9
INEFFECTIVE, HEARTWORM LARVAE 8
Ataxia 8
Decreased appetite 7
Overdose 7
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 22
Milbemycin Oxime + Spinosad 16
Pyrantel Pamoate;Sarolaner 15
Afoxolaner 12
Carprofen 11
Oclacitinib Maleate 11
Fluralaner Chew Tablets 10
Spinosad 9
Milbemycin Oxime + Praziquantel 8
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 7
Ivermectin 7
Bedinvetmab 6
Milbemycin 5
Trilostane 5
Ivermectin 272Mcg, Pyrantel Pamoate 228Mg, Praziquantel 228Mg 5
Outcome Breakdown
Recovered/Normal
74 (36.1%)
Outcome Unknown
63 (30.7%)
Ongoing
49 (23.9%)
Died
7 (3.4%)
Recovered with Sequela
7 (3.4%)
Euthanized
5 (2.4%)
Gender Distribution
Male 126 (55.5%)
Female 93 (41.0%)
Unknown 6 (2.6%)
Mixed 2 (0.9%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 12 | |
| 2011 | 18 | |
| 2012 | 19 | |
| 2013 | 20 | |
| 2014 | 14 | |
| 2015 | 26 | |
| 2016 | 25 | |
| 2017 | 11 | |
| 2018 | 15 | |
| 2019 | 9 | |
| 2020 | 8 | |
| 2021 | 6 | |
| 2022 | 13 | |
| 2023 | 7 | |
| 2024 | 16 | |
| 2025 | 8 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #177 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.