Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
4,292
Total Reports
164
Deaths Reported
380.0%
Death Rate
3.8 yr
Avg Age at Report
Average weight at time of report: 39.7 kg (87.5 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 871
Vomiting 610
INEFFECTIVE, HEARTWORM LARVAE 316
Lethargy (see also Central nervous system depression in 'Neurological') 246
Diarrhoea 218
Lack of efficacy (endoparasite) - hookworm 212
Lack of efficacy (ectoparasite) - flea 196
Emesis 196
Lack of efficacy - NOS 180
Lack of efficacy (ectoparasite) - tick NOS 160
Lack of efficacy (bacteria) - Borrelia 134
Seizure NOS 132
Underdose 109
Cardiac disorder NOS 101
Panting 97
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 821
Milbemycin Oxime + Spinosad 670
Pyrantel Pamoate;Sarolaner 422
Milbemycin Oxime + Praziquantel 383
Moxidectin 376
Afoxolaner 333
Fluralaner 13.64% 12-Week Chew 160
Fluralaner Chew Tablets 140
Spinosad 132
Melarsomine Dihydrochloride 126
Bedinvetmab 118
Carprofen 92
Oclacitinib Maleate 79
Sarolaner 79
Lotilaner 75
Outcome Breakdown
Outcome Unknown
1,424 (34.5%)
Ongoing
1,403 (34.0%)
Recovered/Normal
908 (22.0%)
Recovered with Sequela
231 (5.6%)
Died
90 (2.2%)
Euthanized
74 (1.8%)
Gender Distribution
Male 2,200 (51.3%)
Female 2,000 (46.6%)
Unknown 71 (1.7%)
Mixed 21 (0.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 85 | |
| 2011 | 120 | |
| 2012 | 149 | |
| 2013 | 180 | |
| 2014 | 173 | |
| 2015 | 174 | |
| 2016 | 238 | |
| 2017 | 238 | |
| 2018 | 261 | |
| 2019 | 322 | |
| 2020 | 363 | |
| 2021 | 365 | |
| 2022 | 403 | |
| 2023 | 436 | |
| 2024 | 484 | |
| 2025 | 301 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #45 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.