Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
3,752
Total Reports
125
Deaths Reported
330.0%
Death Rate
5.0 yr
Avg Age at Report
Average weight at time of report: 25.5 kg (56.2 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 521
Vomiting 509
Lack of efficacy (endoparasite) - hookworm 350
INEFFECTIVE, HEARTWORM LARVAE 290
Diarrhoea 211
Lethargy (see also Central nervous system depression in 'Neurological') 197
Lack of efficacy - NOS 173
Seizure NOS 163
Digestive tract disorder NOS 162
Lack of efficacy (ectoparasite) - tick NOS 145
Lack of efficacy (endoparasite) - roundworm NOS 130
Emesis 111
INEFFECTIVE, HOOKS 101
INEFFECTIVE, ASCARIDS NOS 98
Ataxia 95
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 630
Milbemycin Oxime + Spinosad 424
Moxidectin 351
Pyrantel Pamoate;Sarolaner 315
Milbemycin Oxime + Praziquantel 308
Afoxolaner 256
Fluralaner Chew Tablets 145
Fluralaner 13.64% 12-Week Chew 129
Carprofen 112
Sarolaner 72
Oclacitinib Maleate 70
Bedinvetmab 70
Prednisone 61
Trilostane 58
Ivermectin, Pyrantel 57
Outcome Breakdown
Outcome Unknown
1,268 (35.7%)
Ongoing
1,163 (32.8%)
Recovered/Normal
823 (23.2%)
Recovered with Sequela
172 (4.8%)
Euthanized
78 (2.2%)
Died
47 (1.3%)
Gender Distribution
Male 1,873 (49.9%)
Female 1,812 (48.3%)
Unknown 49 (1.3%)
Mixed 18 (0.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 99 | |
| 2011 | 116 | |
| 2012 | 145 | |
| 2013 | 140 | |
| 2014 | 179 | |
| 2015 | 181 | |
| 2016 | 254 | |
| 2017 | 283 | |
| 2018 | 294 | |
| 2019 | 308 | |
| 2020 | 294 | |
| 2021 | 289 | |
| 2022 | 279 | |
| 2023 | 316 | |
| 2024 | 342 | |
| 2025 | 233 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #53 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.