Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
126
Total Reports
5
Deaths Reported
400.0%
Death Rate
6.3 yr
Avg Age at Report
Average weight at time of report: 5.5 kg (12.1 lbs)
Top Reported Reactions
Vomiting 38
Lethargy (see also Central nervous system depression in 'Neurological') 19
Lack of efficacy (ectoparasite) - flea 15
Emesis 14
Diarrhoea 14
Lack of efficacy - NOS 13
Behavioural disorder NOS 7
Shaking 7
Ataxia 6
Seizure NOS 5
Death by euthanasia 5
Not eating 5
Digestive tract disorder NOS 4
Bloody diarrhoea 4
Anorexia 4
Most Referenced Drugs
Milbemycin Oxime + Spinosad 55
Spinosad 11
Pyrantel Pamoate;Sarolaner 10
Selamectin 9
Milbemycin Oxime + Praziquantel 8
Fluralaner 13.64% 12-Week Chew 7
Moxidectin 5
Oclacitinib Maleate 5
Sarolaner 4
Trilostane 4
Lotilaner 4
Prednisone 3
Nitenpyram 3
Milbemycin Oxime 3
Diphenhydramine 2
Outcome Breakdown
Recovered/Normal
52 (41.3%)
Outcome Unknown
39 (31.0%)
Ongoing
28 (22.2%)
Euthanized
5 (4.0%)
Recovered with Sequela
2 (1.6%)
Gender Distribution
Male 70 (55.6%)
Female 55 (43.7%)
Unknown 1 (0.8%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2012 | 6 | |
| 2013 | 10 | |
| 2014 | 25 | |
| 2015 | 10 | |
| 2016 | 10 | |
| 2017 | 11 | |
| 2018 | 11 | |
| 2019 | 7 | |
| 2020 | 7 | |
| 2021 | 10 | |
| 2022 | 3 | |
| 2023 | 6 | |
| 2024 | 5 | |
| 2025 | 5 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #219 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.