Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
97
Total Reports
5
Deaths Reported
520.0%
Death Rate
5.9 yr
Avg Age at Report
Average weight at time of report: 28.6 kg (63.1 lbs)
Top Reported Reactions
Vomiting 22
Lethargy (see also Central nervous system depression in 'Neurological') 9
Seizure NOS 9
Emesis 7
Diarrhoea 6
Lack of efficacy (endoparasite) - hookworm 6
Ataxia 6
Death by euthanasia 4
INEFFECTIVE, HEARTWORM LARVAE 4
Emesis (multiple) 4
Digestive tract disorder NOS 4
Lack of efficacy (endoparasite) - heartworm 4
Depression 3
Trembling 3
Systemic disorder NOS 3
Most Referenced Drugs
Milbemycin Oxime + Spinosad 24
Pyrantel Pamoate;Sarolaner 12
Milbemycin Oxime + Praziquantel 7
Spinosad 6
Moxidectin 6
Ivermectin + Pyrantel As Pamoate Salt 5
Selamectin 3
Carprofen 3
Ivermectin 3
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 3
Fluralaner Chew Tablets 3
Lotilaner 3
Ivermectin, Pyrantel 2
Trilostane 2
Firocoxib 2
Outcome Breakdown
Recovered/Normal
33 (40.2%)
Outcome Unknown
28 (34.1%)
Ongoing
13 (15.9%)
Died
3 (3.7%)
Recovered with Sequela
3 (3.7%)
Euthanized
2 (2.4%)
Gender Distribution
Male 51 (52.6%)
Female 39 (40.2%)
Unknown 7 (7.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 8 | |
| 2011 | 9 | |
| 2012 | 7 | |
| 2013 | 3 | |
| 2014 | 6 | |
| 2015 | 5 | |
| 2016 | 8 | |
| 2017 | 5 | |
| 2018 | 5 | |
| 2019 | 6 | |
| 2020 | 5 | |
| 2021 | 6 | |
| 2022 | 5 | |
| 2023 | 6 | |
| 2024 | 9 | |
| 2025 | 4 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #231 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.