Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
17,328
Total Reports
540
Deaths Reported
310.0%
Death Rate
4.0 yr
Avg Age at Report
Average weight at time of report: 26.4 kg (58.2 lbs)
Top Reported Reactions
Vomiting 3,453
Lack of efficacy (endoparasite) - heartworm 2,152
Emesis 1,693
Lethargy (see also Central nervous system depression in 'Neurological') 1,340
Lack of efficacy (ectoparasite) - flea 1,219
INEFFECTIVE, HEARTWORM LARVAE 1,210
Diarrhoea 1,069
Lack of efficacy - NOS 827
Lack of efficacy (endoparasite) - hookworm 653
Anorexia 465
Emesis (multiple) 441
Not eating 374
Seizure NOS 369
INEFFECTIVE, HOOKS 352
Ataxia 351
Most Referenced Drugs
Milbemycin Oxime + Spinosad 4,469
Ivermectin + Pyrantel As Pamoate Salt 2,672
Spinosad 1,395
Afoxolaner 1,212
Milbemycin Oxime + Praziquantel 1,187
Fluralaner Chew Tablets 883
Fluralaner 13.64% 12-Week Chew 607
Nitenpyram 438
Imidacloprid + Moxidectin 389
Melarsomine Dihydrochloride 285
Ivermectin 278
Ivermectin + Pyrantel 262
Melarsomine Dihydrochloride Injection 249
Tigilanol Tiglate 247
Lotilaner 245
Outcome Breakdown
Outcome Unknown
6,679 (40.9%)
Recovered/Normal
5,370 (32.9%)
Ongoing
2,706 (16.6%)
Recovered with Sequela
1,020 (6.3%)
Died
332 (2.0%)
Euthanized
212 (1.3%)
Gender Distribution
Male 8,531 (49.2%)
Female 8,479 (48.9%)
Unknown 257 (1.5%)
Mixed 61 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 547 | |
| 2011 | 529 | |
| 2012 | 874 | |
| 2013 | 1,268 | |
| 2014 | 1,153 | |
| 2015 | 1,364 | |
| 2016 | 1,415 | |
| 2017 | 1,521 | |
| 2018 | 1,363 | |
| 2019 | 1,368 | |
| 2020 | 1,364 | |
| 2021 | 1,144 | |
| 2022 | 969 | |
| 2023 | 912 | |
| 2024 | 919 | |
| 2025 | 618 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #12 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.