Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
347
Total Reports
10
Deaths Reported
290.0%
Death Rate
4.4 yr
Avg Age at Report
Average weight at time of report: 23.8 kg (52.5 lbs)
Top Reported Reactions
Vomiting 91
Lethargy (see also Central nervous system depression in 'Neurological') 33
Diarrhoea 33
Lack of efficacy (bacteria) - Borrelia 25
Lack of efficacy (endoparasite) - hookworm 16
Emesis 14
Lack of efficacy - NOS 13
Seizure NOS 13
Lack of efficacy (endoparasite) - roundworm NOS 13
INEFFECTIVE, HEARTWORM LARVAE 12
Lack of efficacy (endoparasite) - heartworm 12
Emesis (multiple) 11
Other abnormal test result NOS 10
Pruritus 10
Lack of efficacy (ectoparasite) - tick NOS 10
Most Referenced Drugs
Pyrantel Pamoate;Sarolaner 77
Milbemycin Oxime + Spinosad 37
Moxidectin 30
Afoxolaner 20
Bedinvetmab 20
Milbemycin Oxime + Praziquantel 19
Ivermectin + Pyrantel As Pamoate Salt 17
Oclacitinib Maleate 14
Lotilaner 13
Recombinant E. Coli Bl21;Recombinant E. Coli Ecl19 10
Sarolaner 8
Selamectin 7
Afoxolaner 68 Mg Chewable Tablets 7
Fluralaner 13.64% 12-Week Chew 7
Lufenuron + Milbemycin Oxime 6
Outcome Breakdown
Recovered/Normal
130 (37.4%)
Ongoing
121 (34.8%)
Outcome Unknown
81 (23.3%)
Euthanized
8 (2.3%)
Recovered with Sequela
6 (1.7%)
Died
2 (0.6%)
Gender Distribution
Male 182 (52.4%)
Female 150 (43.2%)
Unknown 11 (3.2%)
Mixed 4 (1.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 2 | |
| 2011 | 1 | |
| 2012 | 10 | |
| 2013 | 11 | |
| 2014 | 14 | |
| 2015 | 18 | |
| 2016 | 22 | |
| 2017 | 25 | |
| 2018 | 25 | |
| 2019 | 23 | |
| 2020 | 22 | |
| 2021 | 35 | |
| 2022 | 32 | |
| 2023 | 41 | |
| 2024 | 44 | |
| 2025 | 22 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #157 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.