Total Reports
19,011
FDA CVM filings
Dog /
FDA CVM · 2025 release 19,011 reports on file
Boxer (German Boxer) - FDA Adverse Event Profile
Adverse-event records for Boxer (German Boxer) (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
With 19,011 reports on file, Boxer (German Boxer) sits at #10 among dog breeds by volume; death-coded share is 4.4% (836 reports).
- #10
- most-reported dog breed
- 4.4%
- death-coded report share
- 4,006
- Vomiting - top reaction
- 4.5 yr
- average age at report
Read report counts next to breed popularity: a bigger number often just means more owners and more vet visits.
Deaths Reported
836
of 19,011 reports
Death Rate
4.4%
death-coded share
Avg Age at Report
4.5 yr
27.9 kg avg weight
Death-Coded Outcome Share
Boxer (German Boxer) death-coded reports 4.4%
Cross-breed median
4.4% of 19,011 boxer (german boxer) reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 27.9 kg (61.5 lbs)
Top Reported Reactions
Vomiting 4,006
Lethargy (see also Central nervous system depression in 'Neurological') 2,285
Emesis 2,235
INEFFECTIVE, HEARTWORM LARVAE 1,208
Diarrhoea 1,157
Lack of efficacy (endoparasite) - heartworm 1,146
Lack of efficacy - NOS 1,003
Lack of efficacy (endoparasite) - hookworm 892
Seizure NOS 791
Anorexia 706
Lack of efficacy (ectoparasite) - flea 603
Hives (see also 'Skin') 559
Digestive tract disorder NOS 508
Other abnormal test result NOS 472
Ataxia 466
Most Referenced Drugs
Milbemycin Oxime + Spinosad 4,949
Ivermectin + Pyrantel As Pamoate Salt 1,843
Moxidectin 1,423
Spinosad 1,380
Afoxolaner 897
Oclacitinib Maleate 732
Pyrantel Pamoate;Sarolaner 724
Milbemycin Oxime + Praziquantel 697
Fluralaner Chew Tablets 620
Carprofen 515
Trilostane 439
Bedinvetmab 425
Fluralaner 13.64% 12-Week Chew 341
Sarolaner 327
Melarsomine Dihydrochloride 300
Outcome Breakdown
Recovered/Normal
6,511 (37.3%)
Outcome Unknown
5,097 (29.2%)
Ongoing
4,075 (23.3%)
Recovered with Sequela
938 (5.4%)
Died
446 (2.6%)
Euthanized
390 (2.2%)
Gender Distribution
Male 9,336 (49.1%)
Female 9,332 (49.1%)
Unknown 295 (1.6%)
Mixed 48 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 826 | |
| 2011 | 1,138 | |
| 2012 | 1,645 | |
| 2013 | 1,622 | |
| 2014 | 1,527 | |
| 2015 | 1,479 | |
| 2016 | 1,466 | |
| 2017 | 1,358 | |
| 2018 | 1,259 | |
| 2019 | 1,221 | |
| 2020 | 1,143 | |
| 2021 | 966 | |
| 2022 | 915 | |
| 2023 | 871 | |
| 2024 | 1,032 | |
| 2025 | 543 | |
Boxer (German Boxer) Pet Health Insights
Boxer (German Boxer) accounts for 19,011 FDA adverse event reports, ranking #10 by volume among dog breeds, with 836 reports (4.4%) coded as a death outcome. Mean age at report: 4.5 years, average weight 27.9 kg (61.5 lbs).
Top reported signs: Vomiting (4,006), Lethargy (see also Central nervous system depression in 'Neurological') (2,285), Emesis (2,235). Most-referenced drug: Milbemycin Oxime + Spinosad (4,949 reports), followed by Ivermectin + Pyrantel As Pamoate Salt (1,843) and Moxidectin (1,423).
Outcome coding on 17,457 status-recorded reports is dominated by Recovered/Normal (37.3%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Dog Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve Boxer (German Boxer)? ▼
There are 19,011 adverse event reports involving Boxer (German Boxer) in the FDA database, with 836 reports involving death (4.4% death rate). Boxer (German Boxer) ranks #10 by report volume.
What are the most common adverse reactions reported for Boxer (German Boxer)? ▼
The most commonly reported adverse reactions for Boxer (German Boxer) are Vomiting (4,006 reports), Lethargy (see also Central nervous system depression in 'Neurological') (2,285 reports), Emesis (2,235 reports), INEFFECTIVE, HEARTWORM LARVAE (1,208 reports), Diarrhoea (1,157 reports).
What drugs are most frequently associated with Boxer (German Boxer) adverse events? ▼
The drugs most frequently referenced in Boxer (German Boxer) adverse event reports are Milbemycin Oxime + Spinosad (4,949 reports), Ivermectin + Pyrantel As Pamoate Salt (1,843 reports), Moxidectin (1,423 reports), Spinosad (1,380 reports), Afoxolaner (897 reports).
What is the average age of Boxer (German Boxer) in adverse event reports? ▼
The average age of Boxer (German Boxer) at the time of adverse event reports is 4.5 years, with an average weight of 27.9 kg (61.5 lbs).
Does a high number of adverse event reports mean Boxer (German Boxer) is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Boxer (German Boxer) safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.