Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
19,011
Total Reports
836
Deaths Reported
440.0%
Death Rate
4.5 yr
Avg Age at Report
Average weight at time of report: 27.9 kg (61.5 lbs)
Top Reported Reactions
Vomiting 4,006
Lethargy (see also Central nervous system depression in 'Neurological') 2,285
Emesis 2,235
INEFFECTIVE, HEARTWORM LARVAE 1,208
Diarrhoea 1,157
Lack of efficacy (endoparasite) - heartworm 1,146
Lack of efficacy - NOS 1,003
Lack of efficacy (endoparasite) - hookworm 892
Seizure NOS 791
Anorexia 706
Lack of efficacy (ectoparasite) - flea 603
Hives (see also 'Skin') 559
Digestive tract disorder NOS 508
Other abnormal test result NOS 472
Ataxia 466
Most Referenced Drugs
Milbemycin Oxime + Spinosad 4,949
Ivermectin + Pyrantel As Pamoate Salt 1,843
Moxidectin 1,423
Spinosad 1,380
Afoxolaner 897
Oclacitinib Maleate 732
Pyrantel Pamoate;Sarolaner 724
Milbemycin Oxime + Praziquantel 697
Fluralaner Chew Tablets 620
Carprofen 515
Trilostane 439
Bedinvetmab 425
Fluralaner 13.64% 12-Week Chew 341
Sarolaner 327
Melarsomine Dihydrochloride 300
Outcome Breakdown
Recovered/Normal
6,511 (37.3%)
Outcome Unknown
5,097 (29.2%)
Ongoing
4,075 (23.3%)
Recovered with Sequela
938 (5.4%)
Died
446 (2.6%)
Euthanized
390 (2.2%)
Gender Distribution
Male 9,336 (49.1%)
Female 9,332 (49.1%)
Unknown 295 (1.6%)
Mixed 48 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 826 | |
| 2011 | 1,138 | |
| 2012 | 1,645 | |
| 2013 | 1,622 | |
| 2014 | 1,527 | |
| 2015 | 1,479 | |
| 2016 | 1,466 | |
| 2017 | 1,358 | |
| 2018 | 1,259 | |
| 2019 | 1,221 | |
| 2020 | 1,143 | |
| 2021 | 966 | |
| 2022 | 915 | |
| 2023 | 871 | |
| 2024 | 1,032 | |
| 2025 | 543 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #10 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.