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2026 FDA CVM data 19,011 reports on file official source

Boxer (German Boxer) — FDA Adverse Event Profile

Adverse-event records and label data for Boxer (German Boxer) (Dog), sourced from the FDA Center for Veterinary Medicine. Refreshed as new reports are filed. Cite PlainBreed when reusing this analysis.

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Annual breed adverse-event registration timeline Bar chart showing yearly FDA Center for Veterinary Medicine adverse event report counts per breed registry cohort, with paw-print tick marks indicating count buckets. 1,259 944.25 629.5 314.75 0 2018 2019 2020 2021 2022 2023 2024 2025 Reports filed Death-coded reports
Annual report volume for Boxer (German Boxer) drawn from FDA CVM filings.

Boxer (German Boxer) (Dog) has 19,011 FDA adverse event reports on record, with 836 deaths reported (440.0% death rate) — ranking #10 by report volume. The most frequently reported reaction is Vomiting (4,006 cases). The top associated drug is Milbemycin Oxime + Spinosad. Average age at report: 4.5 years.

Total Reports

19,011

FDA CVM filings

Deaths Reported

836

of 19,011 reports

Death Rate

440.0%

death-coded share

Avg Age at Report

4.5 yr

27.9 kg avg weight

Death-Coded Outcome Share

Boxer (German Boxer) death-coded reports 100.0%
Database median

440.0% of 19,011 reports involved a death outcome. Read alongside breed popularity, veterinary access, and owner awareness — these shape how many events ever reach the FDA. The 12% comparison line is the rough cross-breed median in the FDA CVM database; values above suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Average weight at time of report: 27.9 kg (61.5 lbs)

Top Reported Reactions

Vomiting 4,006
Lethargy (see also Central nervous system depression in 'Neurological') 2,285
Emesis 2,235
INEFFECTIVE, HEARTWORM LARVAE 1,208
Diarrhoea 1,157
Lack of efficacy (endoparasite) - heartworm 1,146
Lack of efficacy - NOS 1,003
Lack of efficacy (endoparasite) - hookworm 892
Seizure NOS 791
Anorexia 706
Lack of efficacy (ectoparasite) - flea 603
Hives (see also 'Skin') 559
Digestive tract disorder NOS 508
Other abnormal test result NOS 472
Ataxia 466

Most Referenced Drugs

Milbemycin Oxime + Spinosad 4,949
Ivermectin + Pyrantel As Pamoate Salt 1,843
Moxidectin 1,423
Spinosad 1,380
Afoxolaner 897
Oclacitinib Maleate 732
Pyrantel Pamoate;Sarolaner 724
Milbemycin Oxime + Praziquantel 697
Fluralaner Chew Tablets 620
Carprofen 515
Trilostane 439
Bedinvetmab 425
Fluralaner 13.64% 12-Week Chew 341
Sarolaner 327
Melarsomine Dihydrochloride 300

Outcome Breakdown

Recovered/Normal
6,511 (37.3%)
Outcome Unknown
5,097 (29.2%)
Ongoing
4,075 (23.3%)
Recovered with Sequela
938 (5.4%)
Died
446 (2.6%)
Euthanized
390 (2.2%)

Gender Distribution

Male 9,336 (49.1%)
Female 9,332 (49.1%)
Unknown 295 (1.6%)
Mixed 48 (0.3%)

Reports by Year

Year Reports Trend
2010 826
2011 1,138
2012 1,645
2013 1,622
2014 1,527
2015 1,479
2016 1,466
2017 1,358
2018 1,259
2019 1,221
2020 1,143
2021 966
2022 915
2023 871
2024 1,032
2025 543
Size-class weight distribution across registered breeds Vertical bar chart showing the distribution of registered breeds across five size classes (Toy, Small, Medium, Large, Giant), each represented by a scaled dog-silhouette and a count value. 118 89 59 30 0 Breeds in class 38 Toy 0–6 kg Chihuahua 64 Small 6–14 kg Beagle 92 Medium 14–27 kg Border Collie 118 Large 27–45 kg Labrador Retriever 41 Giant 45–90 kg Great Dane Size-Class Distribution
Where Boxer (German Boxer) sits in the registered size-class taxonomy. Average reported weight: 27.9 kg.
Breed-group distribution donut chart Donut chart with kennel-club-ribbon center showing breed counts across the eight standard breed groups (Sporting, Hound, Working, Terrier, Toy, Non-Sporting, Herding, Miscellaneous). CH Sporting 32 · 14.2% Hound 36 · 15.9% Working 33 · 14.6% Terrier 31 · 13.7% Toy 23 · 10.2% Non-Sporting 21 · 9.3% Herding 32 · 14.2% Misc. 18 · 8.0% Breed-Group Classification 226 breeds across 8 taxonomic groups
Eight standard breed-group classifications used by major registries (AKC's seven groups plus Miscellaneous). Provides taxonomic context for breed lookups.

Boxer (German Boxer) Pet Health Insights

Across the FDA Center for Veterinary Medicine adverse event database, Boxer (German Boxer) accounts for 19,011 submitted reports and currently ranks #10 by report volume within the dog population. Of those reports, 836 involved a death outcome — a 440.0% case-fatality figure calculated directly from the underlying FDA records rather than from external mortality studies. The mean age at time of reporting is 4.5 years, with an average recorded body weight of 27.9 kg (61.5 lbs). These figures reflect the voluntary reporting pool only and should be read alongside breed popularity, veterinary access, and owner awareness — all of which shape how many events ever reach the FDA.

The most frequently reported clinical signs for Boxer (German Boxer) are Vomiting (4,006 reports), Lethargy (see also Central nervous system depression in 'Neurological') (2,285 reports), Emesis (2,235 reports), together capturing a substantial share of the top-reaction traffic seen in this breed's record. On the product side, Milbemycin Oxime + Spinosad appears in 4,949 reports and is the single most-referenced drug, followed by Ivermectin + Pyrantel As Pamoate Salt (1,843) and Moxidectin (1,423). Counts like these surface which therapeutic classes dominate the reporting stream — useful context when comparing reactions across breeds of the same dog species.

Outcome coding on the 17,457 reports with a recorded status is dominated by Recovered/Normal (37.3% of coded outcomes). Annual submission volume ranges from 2,010 to 2,025 reports across the 16 years on file, indicating the reporting trend is shaped as much by awareness cycles as by underlying clinical events. Because FDA adverse event reports describe correlation rather than causation, these numbers are most useful as a signal of where to ask further questions with a veterinarian — not as a standalone risk score for any individual dog.

Understanding Boxer (German Boxer) Adverse Event Data

With 19,011 adverse event reports, Boxer (German Boxer) has one of the larger report volumes in the FDA database. This typically reflects breed popularity rather than inherent health risk — more pets of a breed means more veterinary encounters and more opportunity for adverse event reporting.

The 440.0% death rate is above average, though this statistic should be interpreted cautiously. Death reports may be overrepresented because serious outcomes are more likely to be reported than mild reactions.

The most frequently referenced drug in adverse reports is Milbemycin Oxime + Spinosad, appearing in 4,949 reports. This may indicate widespread use of the medication rather than a specific safety concern for Boxer (German Boxer).

Other Dog Breeds

Frequently Asked Questions

How many FDA adverse event reports involve Boxer (German Boxer)?
There are 19,011 adverse event reports involving Boxer (German Boxer) in the FDA database, with 836 reports involving death (440.0% death rate). Boxer (German Boxer) ranks #10 by report volume.
What are the most common adverse reactions reported for Boxer (German Boxer)?
The most commonly reported adverse reactions for Boxer (German Boxer) are Vomiting (4,006 reports), Lethargy (see also Central nervous system depression in 'Neurological') (2,285 reports), Emesis (2,235 reports), INEFFECTIVE, HEARTWORM LARVAE (1,208 reports), Diarrhoea (1,157 reports).
What drugs are most frequently associated with Boxer (German Boxer) adverse events?
The drugs most frequently referenced in Boxer (German Boxer) adverse event reports are Milbemycin Oxime + Spinosad (4,949 reports), Ivermectin + Pyrantel As Pamoate Salt (1,843 reports), Moxidectin (1,423 reports), Spinosad (1,380 reports), Afoxolaner (897 reports).
What is the average age of Boxer (German Boxer) in adverse event reports?
The average age of Boxer (German Boxer) at the time of adverse event reports is 4.5 years, with an average weight of 27.9 kg (61.5 lbs).
Does a high number of adverse event reports mean Boxer (German Boxer) is unhealthy?
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Boxer (German Boxer) safety data come from?
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.

Guides & Resources

Related Data Sources

Data Sources & Methodology

Adverse event data sourced from the FDA Center for Veterinary Medicine via the openFDA Animal & Veterinary Adverse Events API. Reports are voluntarily submitted by pet owners, veterinarians, and product manufacturers.

Boxer (German Boxer) ranks #10 by total report volume. Death rate (440.0%) reflects the proportion of reports involving death and should not be interpreted as a breed-specific mortality rate. Reporting biases, breed popularity, and veterinary access all influence report counts.

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial