Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,253
Total Reports
98
Deaths Reported
780.0%
Death Rate
4.4 yr
Avg Age at Report
Average weight at time of report: 50.6 kg (111.6 lbs)
Top Reported Reactions
Vomiting 218
INEFFECTIVE, HEARTWORM LARVAE 94
Diarrhoea 89
Emesis 85
Lethargy (see also Central nervous system depression in 'Neurological') 84
Seizure NOS 84
Lack of efficacy - NOS 74
Lack of efficacy (endoparasite) - heartworm 67
Anorexia 58
Lack of efficacy (ectoparasite) - flea 53
Underdose 47
Death by euthanasia 46
Death 43
Weight loss 41
Lack of efficacy (endoparasite) - hookworm 40
Most Referenced Drugs
Milbemycin Oxime + Spinosad 211
Ivermectin + Pyrantel As Pamoate Salt 157
Carprofen 91
Pyrantel Pamoate;Sarolaner 88
Afoxolaner 79
Milbemycin Oxime + Praziquantel 78
Spinosad 69
Fluralaner Chew Tablets 63
Bedinvetmab 62
Moxidectin 58
Fluralaner 13.64% 12-Week Chew 52
Oclacitinib Maleate 35
Sarolaner 33
Gabapentin 29
Prednisone 28
Outcome Breakdown
Outcome Unknown
394 (34.0%)
Ongoing
314 (27.1%)
Recovered/Normal
313 (27.0%)
Died
52 (4.5%)
Euthanized
46 (4.0%)
Recovered with Sequela
39 (3.4%)
Gender Distribution
Male 692 (55.2%)
Female 523 (41.7%)
Unknown 33 (2.6%)
Mixed 5 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 52 | |
| 2011 | 75 | |
| 2012 | 81 | |
| 2013 | 88 | |
| 2014 | 60 | |
| 2015 | 77 | |
| 2016 | 82 | |
| 2017 | 96 | |
| 2018 | 100 | |
| 2019 | 81 | |
| 2020 | 76 | |
| 2021 | 59 | |
| 2022 | 63 | |
| 2023 | 84 | |
| 2024 | 105 | |
| 2025 | 74 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #98 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.