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Breed profile · FDA CVM July 2026 extract

Mastiff adverse-event record

Adverse-event filings for Mastiff (Dog) in the FDA Center for Veterinary Medicine openFDA extract. Browse dog breeds, reactions, and outcomes below.

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#65 of 510
by report volume (all breeds)
2,950
FDA CVM reports on file
6.2%
death-coded share of reports
#99 of 275
by death-coded share (≥50 reports)

How the 2,950 reports break down

By recorded gender -- every report on file for Mastiff, no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 245 183.75 122.5 61.25 0 2016 2017 2018 2019 2020 2021 2022 2023 Reports filed Death-coded reports
Annual report volume for Mastiff drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Mastiff ranks #65 of 510 by total reports (2,950) and #99 of 275 by death-coded share (6.2%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#65
This breed, reports of 510
#99
This breed, death share of 275

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Mastiff has 2,950 reports now versus 2,950 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Mastiff changes

Total Reports

2,950

High report volume

Deaths Reported

182

of 2,950 reports

Death-coded share of reports

6.2%

Above-median death-coded share

Avg Age at Report

3.4 yr

49.7 kg avg weight

Breed Safety Scorecard

C- (52/100)

A weighted composite across 4 of 4 dimensions, each benchmarked against every tracked breed with at least 200 reports (n=185). Dimensions with insufficient data drop out and their weight redistributes to the rest, so a missing input never silently deflates the score.

Death rate F
6.2%

Share of reports coded as a fatality

Euthanasia rate D
2.3%

Share of reports resulting in euthanasia

Full recovery rate C+
32.4%

Share of reports coded "Recovered/Normal"

5-year trend B+
-19%

Change in annual report volume over the last 5 complete years

Death-Coded Outcome Share

Mastiff death-coded reports 6.2%
Cross-breed median

6.2% of 2,950 mastiff reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Where Mastiff's death-coded share sits among indexed breeds

Death-coded share of FDA CVM reports, breeds with ≥50 reports (July 2026 extract)

6% 64th percentile Higher share than 64% of 275 indexed breeds

5%–10%: 1 indexed breeds (0%). This entry sits in this band. 20%–25%: 2 indexed breeds (1%). Above this entry. 25%–30%: 3 indexed breeds (1%). Above this entry. 30%–35%: 4 indexed breeds (1%). Above this entry. 35%–40%: 5 indexed breeds (2%). Above this entry. 40%–45%: 6 indexed breeds (2%). Above this entry. 45%–50%: 3 indexed breeds (1%). Above this entry. 50%–55%: 7 indexed breeds (3%). Above this entry. 55%–60%: 7 indexed breeds (3%). Above this entry. 60%–65%: 21 indexed breeds (8%). Above this entry. 65%–70%: 11 indexed breeds (4%). Above this entry. 70%–75%: 15 indexed breeds (5%). Above this entry. 75%–80%: 13 indexed breeds (5%). Above this entry. 80%–85%: 11 indexed breeds (4%). Above this entry. 85%–90%: 12 indexed breeds (4%). Above this entry. 90%–95%: 12 indexed breeds (4%). Above this entry. 95%–100%: 142 indexed breeds (52%). Above this entry. Mastiff 5% 100% every breed with ≥50 FDA reports, bucketed by value

Each bar is a band; taller bars hold more indexed breeds. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.

Source FDA Center for Veterinary Medicine, openFDA adverse event extract (PlainBreed) · July 2026 extract

This histogram uses the same ≥50-report cohort as the highest death-coded share ranking. A higher share means more of this breed's reported events were death-coded, not a mortality rate for living animals.

Average weight at time of report: 49.7 kg (109.6 lbs)

Top Reported Reactions

Vomiting 604
Emesis 395
Lethargy (see also Central nervous system depression in 'Neurological') 243
Diarrhoea 206
Lack of efficacy (endoparasite) - heartworm 202
INEFFECTIVE, HEARTWORM LARVAE 174
Lack of efficacy - NOS 163
Lack of efficacy (ectoparasite) - flea 149
Lack of efficacy (endoparasite) - hookworm 110
Seizure NOS 99
Anorexia 97
Death 96
Underdose 85
Other abnormal test result NOS 80
Death by euthanasia 75

Most Referenced Drugs

Milbemycin Oxime + Spinosad 777
Ivermectin + Pyrantel As Pamoate Salt 346
Spinosad 278
Moxidectin 210
Afoxolaner 173
Pyrantel Pamoate;Sarolaner 155
Fluralaner Chew Tablets 129
Carprofen 115
Oclacitinib Maleate 109
Milbemycin Oxime + Praziquantel 106
Sarolaner 75
Melarsomine Dihydrochloride 59
Lufenuron + Milbemycin Oxime 46
Fluralaner 13.64% 12-Week Chew 44
Ivermectin, Pyrantel 43

Outcome Breakdown

Recovered/Normal
956 (36.0%)
Outcome Unknown
758 (28.5%)
Ongoing
656 (24.7%)
Died
113 (4.3%)
Recovered with Sequela
105 (4.0%)
Euthanized
69 (2.6%)

Gender Distribution

Male 1,710 (58.0%)
Female 1,168 (39.6%)
Unknown 60 (2.0%)
Mixed 12 (0.4%)

Reports by Year

Year Reports Trend
2010 127
2011 246
2012 280
2013 230
2014 212
2015 219
2016 245
2017 236
2018 208
2019 201
2020 224
2021 195
2022 165
2023 162

Mastiff: high-volume FDA adverse-event cohort

Signature read: 2,950 reports place Mastiff in the upper third of breed filing volume (#65 of 510). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Mastiff sits at #65 of 510 by report volume among all breeds and #56 of 298 among dog breeds, with 2,950 reports and 182 (6.2%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #99 of 275. Mean age at report: 3.4 years, average weight 49.7 kg (109.6 lbs).

Top reported signs: Vomiting (604), Emesis (395), Lethargy (see also Central nervous system depression in 'Neurological') (243). Most-referenced drug: Milbemycin Oxime + Spinosad (777 reports), followed by Ivermectin + Pyrantel As Pamoate Salt (346) and Spinosad (278).

Outcome coding on 2,657 status-recorded reports is dominated by Recovered/Normal (36.0%). Annual submissions ranged 127-2,023 across 14 years on file.

Dog Breeds With a Similar Report Volume

Showing 6 of 297 dog breeds in our dataset, ranked by closest report volume.

Mountain Dog - Bernese
3,012 reports · 4.2% death-coded
Corgi (unspecified)
2,865 reports · 4.2% death-coded
Shepherd (unspecified)
2,865 reports · 4.4% death-coded
Terrier - Rat
3,078 reports · 4.3% death-coded
Collie (unspecified)
3,131 reports · 4.8% death-coded
Terrier - Bull - Staffordshire
2,752 reports · 4.4% death-coded

Nationwide breeds with similar profiles

High-volume peer sets for Mastiff drawn from openFDA outside the Dog family so the neighborhoods are not species containment (the similar-volume list above stays within species).

Similar death-coded share

Nearest other-species breeds with ≥50 reports (6.2% death-coded here).

Crossbred Feline/cat 6.3% · Cat Norwegian Forest 5.7% · Cat Domestic Longhair 7.0% · Cat Snowshoe 7.0% · Cat

Similar average weight

Nearest other-species breeds by reported average weight (49.7 kg here).

Mixed (Pig) 49.2 kg · Pig Duroc 50.4 kg · Pig Mixed (Goat) 48.5 kg · Goat Crossbred Porcine/Pig 51.1 kg · Pig

What to do with this dog

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve Mastiff? ▼
There are 2,950 adverse event reports involving Mastiff in the FDA database, of which 182 were death-coded (6.2% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Mastiff ranks #65 of 510 by report volume among all breeds PlainBreed indexes (#56 of 298 among dog breeds).
Where does Mastiff sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Mastiff is #65 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Dog, it is #56 of 298. Among breeds with at least 50 reports, its death-coded share ranks #99 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Mastiff? ▼
The most commonly reported adverse reactions for Mastiff are Vomiting (604 reports), Emesis (395 reports), Lethargy (see also Central nervous system depression in 'Neurological') (243 reports), Diarrhoea (206 reports), Lack of efficacy (endoparasite) - heartworm (202 reports).
What drugs are most frequently associated with Mastiff adverse events? ▼
The drugs most frequently referenced in Mastiff adverse event reports are Milbemycin Oxime + Spinosad (777 reports), Ivermectin + Pyrantel As Pamoate Salt (346 reports), Spinosad (278 reports), Moxidectin (210 reports), Afoxolaner (173 reports).
What is the average age of Mastiff in adverse event reports? ▼
The average age of Mastiff at the time of adverse event reports is 3.4 years, with an average weight of 49.7 kg (109.6 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Mastiff (Dog), extract as of July 2026 extract. 2,950 reports · 182 death-coded (6.2% of reports, not a mortality rate) · #65 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →