Total Reports
2,952
FDA CVM filings
Dog /
FDA CVM · 2025 release 2,952 reports on file
Mastiff - FDA Adverse Event Profile
Adverse-event records for Mastiff (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Mastiff's FDA record: #63 most-reported dog breed, 2,952 total reports, 6.2% death-coded (182 reports).
- #63
- most-reported dog breed
- 6.2%
- death-coded report share
- 604
- Vomiting - top reaction
- 3.4 yr
- average age at report
Higher volume usually means a more popular breed, not a riskier one, compare against how common the breed is.
Deaths Reported
182
of 2,952 reports
Death Rate
6.2%
death-coded share
Avg Age at Report
3.4 yr
49.7 kg avg weight
Death-Coded Outcome Share
Mastiff death-coded reports 6.2%
Cross-breed median
6.2% of 2,952 mastiff reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 49.7 kg (109.6 lbs)
Top Reported Reactions
Vomiting 604
Emesis 395
Lethargy (see also Central nervous system depression in 'Neurological') 243
Diarrhoea 206
Lack of efficacy (endoparasite) - heartworm 203
INEFFECTIVE, HEARTWORM LARVAE 174
Lack of efficacy - NOS 163
Lack of efficacy (ectoparasite) - flea 149
Lack of efficacy (endoparasite) - hookworm 110
Seizure NOS 99
Anorexia 97
Death 96
Underdose 85
Other abnormal test result NOS 80
Death by euthanasia 75
Most Referenced Drugs
Milbemycin Oxime + Spinosad 777
Ivermectin + Pyrantel As Pamoate Salt 346
Spinosad 278
Moxidectin 210
Afoxolaner 173
Pyrantel Pamoate;Sarolaner 156
Fluralaner Chew Tablets 129
Carprofen 115
Oclacitinib Maleate 109
Milbemycin Oxime + Praziquantel 106
Sarolaner 75
Melarsomine Dihydrochloride 59
Lufenuron + Milbemycin Oxime 46
Fluralaner 13.64% 12-Week Chew 44
Ivermectin, Pyrantel 43
Outcome Breakdown
Recovered/Normal
956 (36.0%)
Outcome Unknown
758 (28.5%)
Ongoing
658 (24.7%)
Died
113 (4.2%)
Recovered with Sequela
105 (3.9%)
Euthanized
69 (2.6%)
Gender Distribution
Male 1,711 (58.0%)
Female 1,169 (39.6%)
Unknown 60 (2.0%)
Mixed 12 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 127 | |
| 2011 | 246 | |
| 2012 | 280 | |
| 2013 | 230 | |
| 2014 | 212 | |
| 2015 | 219 | |
| 2016 | 245 | |
| 2017 | 236 | |
| 2018 | 208 | |
| 2019 | 201 | |
| 2020 | 224 | |
| 2021 | 195 | |
| 2022 | 166 | |
| 2023 | 163 | |
Mastiff Pet Health Insights
Mastiff accounts for 2,952 FDA adverse event reports, ranking #63 by volume among dog breeds, with 182 reports (6.2%) coded as a death outcome. Mean age at report: 3.4 years, average weight 49.7 kg (109.6 lbs).
Top reported signs: Vomiting (604), Emesis (395), Lethargy (see also Central nervous system depression in 'Neurological') (243). Most-referenced drug: Milbemycin Oxime + Spinosad (777 reports), followed by Ivermectin + Pyrantel As Pamoate Salt (346) and Spinosad (278).
Outcome coding on 2,659 status-recorded reports is dominated by Recovered/Normal (36.0%). Annual submissions ranged 2,010-2,023 across 14 years on file.
Dog Breeds With a Similar Report Volume
Terrier - Rat
3,013 reports · 4.3% death rate
Spaniel (unspecified)
3,074 reports · 4.9% death rate
Collie (unspecified)
3,080 reports · 4.8% death rate
Mountain Dog - Bernese
2,817 reports · 4.5% death rate
Lhasa Apso
3,154 reports · 3.6% death rate
Corgi (unspecified)
2,744 reports · 4.3% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Mastiff? ▼
There are 2,952 adverse event reports involving Mastiff in the FDA database, with 182 reports involving death (6.2% death rate). Mastiff ranks #63 by report volume.
What are the most common adverse reactions reported for Mastiff? ▼
The most commonly reported adverse reactions for Mastiff are Vomiting (604 reports), Emesis (395 reports), Lethargy (see also Central nervous system depression in 'Neurological') (243 reports), Diarrhoea (206 reports), Lack of efficacy (endoparasite) - heartworm (203 reports).
What drugs are most frequently associated with Mastiff adverse events? ▼
The drugs most frequently referenced in Mastiff adverse event reports are Milbemycin Oxime + Spinosad (777 reports), Ivermectin + Pyrantel As Pamoate Salt (346 reports), Spinosad (278 reports), Moxidectin (210 reports), Afoxolaner (173 reports).
What is the average age of Mastiff in adverse event reports? ▼
The average age of Mastiff at the time of adverse event reports is 3.4 years, with an average weight of 49.7 kg (109.6 lbs).
Does a high number of adverse event reports mean Mastiff is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Mastiff safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.