Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
2,952
Total Reports
182
Deaths Reported
620.0%
Death Rate
3.4 yr
Avg Age at Report
Average weight at time of report: 49.7 kg (109.6 lbs)
Top Reported Reactions
Vomiting 604
Emesis 395
Lethargy (see also Central nervous system depression in 'Neurological') 243
Diarrhoea 206
Lack of efficacy (endoparasite) - heartworm 203
INEFFECTIVE, HEARTWORM LARVAE 174
Lack of efficacy - NOS 163
Lack of efficacy (ectoparasite) - flea 149
Lack of efficacy (endoparasite) - hookworm 110
Seizure NOS 99
Anorexia 97
Death 96
Underdose 85
Other abnormal test result NOS 80
Death by euthanasia 75
Most Referenced Drugs
Milbemycin Oxime + Spinosad 777
Ivermectin + Pyrantel As Pamoate Salt 346
Spinosad 278
Moxidectin 210
Afoxolaner 173
Pyrantel Pamoate;Sarolaner 156
Fluralaner Chew Tablets 129
Carprofen 115
Oclacitinib Maleate 109
Milbemycin Oxime + Praziquantel 106
Sarolaner 75
Melarsomine Dihydrochloride 59
Lufenuron + Milbemycin Oxime 46
Fluralaner 13.64% 12-Week Chew 44
Ivermectin, Pyrantel 43
Outcome Breakdown
Recovered/Normal
956 (36.0%)
Outcome Unknown
758 (28.5%)
Ongoing
658 (24.7%)
Died
113 (4.2%)
Recovered with Sequela
105 (3.9%)
Euthanized
69 (2.6%)
Gender Distribution
Male 1,711 (58.0%)
Female 1,169 (39.6%)
Unknown 60 (2.0%)
Mixed 12 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 127 | |
| 2011 | 246 | |
| 2012 | 280 | |
| 2013 | 230 | |
| 2014 | 212 | |
| 2015 | 219 | |
| 2016 | 245 | |
| 2017 | 236 | |
| 2018 | 208 | |
| 2019 | 201 | |
| 2020 | 224 | |
| 2021 | 195 | |
| 2022 | 166 | |
| 2023 | 163 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #63 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.