Total Reports
3,080
FDA CVM filings
Dog /
FDA CVM · 2025 release 3,080 reports on file
Collie (unspecified) - FDA Adverse Event Profile
Adverse-event records for Collie (unspecified) (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Among dog breeds, Collie (unspecified) is #59 by FDA report volume; 4.8% of its 3,080 reports (147) were death-coded.
- #59
- most-reported dog breed
- 4.8%
- death-coded report share
- 535
- Vomiting - top reaction
- 5.8 yr
- average age at report
Higher volume usually means a more popular breed, not a riskier one, compare against how common the breed is.
Deaths Reported
147
of 3,080 reports
Death Rate
4.8%
death-coded share
Avg Age at Report
5.8 yr
26.0 kg avg weight
Death-Coded Outcome Share
Collie (unspecified) death-coded reports 4.8%
Cross-breed median
4.8% of 3,080 collie (unspecified) reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 26.0 kg (57.3 lbs)
Top Reported Reactions
Vomiting 535
Emesis 342
Diarrhoea 287
Lethargy (see also Central nervous system depression in 'Neurological') 265
Lack of efficacy (endoparasite) - heartworm 181
INEFFECTIVE, HEARTWORM LARVAE 171
Lack of efficacy - NOS 163
Seizure NOS 153
Lack of efficacy (endoparasite) - hookworm 150
Lack of efficacy (ectoparasite) - flea 123
Anorexia 105
Ataxia 100
Other abnormal test result NOS 83
Digestive tract disorder NOS 82
Death by euthanasia 73
Most Referenced Drugs
Milbemycin Oxime + Spinosad 572
Ivermectin + Pyrantel As Pamoate Salt 294
Afoxolaner 225
Spinosad 209
Pyrantel Pamoate;Sarolaner 156
Milbemycin Oxime + Praziquantel 150
Fluralaner Chew Tablets 114
Moxidectin 104
Carprofen 93
Milbemycin Oxime 90
Bedinvetmab 85
Selamectin 73
Oclacitinib Maleate 67
Grapiprant 67
Sarolaner 64
Outcome Breakdown
Recovered/Normal
1,026 (36.3%)
Outcome Unknown
867 (30.6%)
Ongoing
664 (23.5%)
Recovered with Sequela
125 (4.4%)
Died
84 (3.0%)
Euthanized
63 (2.2%)
Gender Distribution
Female 1,541 (50.0%)
Male 1,438 (46.7%)
Unknown 91 (3.0%)
Mixed 10 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 127 | |
| 2011 | 239 | |
| 2012 | 343 | |
| 2013 | 239 | |
| 2014 | 219 | |
| 2015 | 233 | |
| 2016 | 207 | |
| 2017 | 180 | |
| 2018 | 184 | |
| 2019 | 182 | |
| 2020 | 180 | |
| 2021 | 147 | |
| 2022 | 135 | |
| 2023 | 162 | |
| 2024 | 192 | |
| 2025 | 111 | |
Collie (unspecified) Pet Health Insights
Collie (unspecified) accounts for 3,080 FDA adverse event reports, ranking #59 by volume among dog breeds, with 147 reports (4.8%) coded as a death outcome. Mean age at report: 5.8 years, average weight 26.0 kg (57.3 lbs).
Top reported signs: Vomiting (535), Emesis (342), Diarrhoea (287). Most-referenced drug: Milbemycin Oxime + Spinosad (572 reports), followed by Ivermectin + Pyrantel As Pamoate Salt (294) and Afoxolaner (225).
Outcome coding on 2,829 status-recorded reports is dominated by Recovered/Normal (36.3%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Dog Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve Collie (unspecified)? ▼
There are 3,080 adverse event reports involving Collie (unspecified) in the FDA database, with 147 reports involving death (4.8% death rate). Collie (unspecified) ranks #59 by report volume.
What are the most common adverse reactions reported for Collie (unspecified)? ▼
The most commonly reported adverse reactions for Collie (unspecified) are Vomiting (535 reports), Emesis (342 reports), Diarrhoea (287 reports), Lethargy (see also Central nervous system depression in 'Neurological') (265 reports), Lack of efficacy (endoparasite) - heartworm (181 reports).
What drugs are most frequently associated with Collie (unspecified) adverse events? ▼
The drugs most frequently referenced in Collie (unspecified) adverse event reports are Milbemycin Oxime + Spinosad (572 reports), Ivermectin + Pyrantel As Pamoate Salt (294 reports), Afoxolaner (225 reports), Spinosad (209 reports), Pyrantel Pamoate;Sarolaner (156 reports).
What is the average age of Collie (unspecified) in adverse event reports? ▼
The average age of Collie (unspecified) at the time of adverse event reports is 5.8 years, with an average weight of 26.0 kg (57.3 lbs).
Does a high number of adverse event reports mean Collie (unspecified) is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Collie (unspecified) safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.