Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
3,080
Total Reports
147
Deaths Reported
480.0%
Death Rate
5.8 yr
Avg Age at Report
Average weight at time of report: 26.0 kg (57.3 lbs)
Top Reported Reactions
Vomiting 535
Emesis 342
Diarrhoea 287
Lethargy (see also Central nervous system depression in 'Neurological') 265
Lack of efficacy (endoparasite) - heartworm 181
INEFFECTIVE, HEARTWORM LARVAE 171
Lack of efficacy - NOS 163
Seizure NOS 153
Lack of efficacy (endoparasite) - hookworm 150
Lack of efficacy (ectoparasite) - flea 123
Anorexia 105
Ataxia 100
Other abnormal test result NOS 83
Digestive tract disorder NOS 82
Death by euthanasia 73
Most Referenced Drugs
Milbemycin Oxime + Spinosad 572
Ivermectin + Pyrantel As Pamoate Salt 294
Afoxolaner 225
Spinosad 209
Pyrantel Pamoate;Sarolaner 156
Milbemycin Oxime + Praziquantel 150
Fluralaner Chew Tablets 114
Moxidectin 104
Carprofen 93
Milbemycin Oxime 90
Bedinvetmab 85
Selamectin 73
Oclacitinib Maleate 67
Grapiprant 67
Sarolaner 64
Outcome Breakdown
Recovered/Normal
1,026 (36.3%)
Outcome Unknown
867 (30.6%)
Ongoing
664 (23.5%)
Recovered with Sequela
125 (4.4%)
Died
84 (3.0%)
Euthanized
63 (2.2%)
Gender Distribution
Female 1,541 (50.0%)
Male 1,438 (46.7%)
Unknown 91 (3.0%)
Mixed 10 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 127 | |
| 2011 | 239 | |
| 2012 | 343 | |
| 2013 | 239 | |
| 2014 | 219 | |
| 2015 | 233 | |
| 2016 | 207 | |
| 2017 | 180 | |
| 2018 | 184 | |
| 2019 | 182 | |
| 2020 | 180 | |
| 2021 | 147 | |
| 2022 | 135 | |
| 2023 | 162 | |
| 2024 | 192 | |
| 2025 | 111 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #59 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.